KLF7 reverses ox-LDL-induced ferroptosis in HMEC-1 cells through transcriptionally activating ALKBH5 to inhibit the m6A modification of ACSL4

Alexander Y, Osto E, Schmidt-Trucksass A, Shechter M, Trifunovic D, Duncker DJ et al (2021) Endothelial function in cardiovascular medicine: a consensus paper of the European society of cardiology working groups on atherosclerosis and vascular biology, aorta and peripheral vascular diseases, coronary pathophysiology and microcirculation, and thrombosis. Cardiovasc Res 117:29–42

Article  CAS  PubMed  Google Scholar 

Brandt G, Sedivy LJ, Mitchell M, Phiel CJ (2023) Vitamin C and transferrin reduce RNA methylation in mouse embryonic stem cells. bioRxiv

Chen C, Hu F, Miao S, Sun L, Jiao Y, Xu M et al (2022a) Transcription factor KLF7 promotes osteoclast differentiation by suppressing HO-1. Front Genet 13:798433

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen F, Li J, Zheng T, Chen T, Yuan Z (2022b) KLF7 alleviates atherosclerotic lesions and inhibits glucose metabolic reprogramming in macrophages by regulating HDAC4/miR-148b-3p/NCOR1. Gerontology 68:1291–1310

Article  CAS  PubMed  Google Scholar 

Dong G, Yu J, Shan G, Su L, Yu N, Yang S (2021) N6-methyladenosine methyltransferase METTL3 promotes angiogenesis and atherosclerosis by upregulating the JAK2/STAT3 pathway via m6A reader IGF2BP1. Front Cell Dev Biol 9:731810

Article  PubMed  PubMed Central  Google Scholar 

Fang Y, Wu X, Gu Y, Shi R, Yu T, Pan Y et al (2023a) LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising JAK1 mRNA in an m(6) A-YTHDF2-dependent manner. Clin Transl Med 13:e1205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang G, Shen Y, Liao D (2023b) ENPP2 alleviates hypoxia/reoxygenation injury and ferroptosis by regulating oxidative stress and mitochondrial function in human cardiac microvascular endothelial cells. Cell Stress Chaperones. https://doi.org/10.1007/s12192-023-01324-1

Article  PubMed  PubMed Central  Google Scholar 

Fu J, Cui X, Zhang X, Cheng M, Li X, Guo Z et al (2021) The Role of m6A ribonucleic acid modification in the occurrence of atherosclerosis. Front Genet 12:733871

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gangxi P, Bohui O, Lin S, Sufeng L, Jianlin C, Xianhua C et al (2019) Decreased serum Kruppel-Like factor 7 level is positively associated with low-density lipoprotein cholesterol level in women with Polycystic ovary syndrome. Clin Lab. https://doi.org/10.7754/Clin.Lab.2018.180908

Article  Google Scholar 

Guo Y, Chai B, Jia J, Yang M, Li Y, Zhang R et al (2021) KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated beta-catenin pathway. Cell Biosci 11:73

Article  CAS  PubMed  PubMed Central  Google Scholar 

He M, Lei H, He X, Liu Y, Wang A, Ren Z et al (2022) METTL14 regulates osteogenesis of bone marrow mesenchymal stem cells via inducing autophagy through m6A/IGF2BPs/Beclin-1 signal axis. Stem Cells Transl Med 11:987–1001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Y, Gong C, Li Z, Liu J, Chen Y, Huang Y et al (2022) Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol Cancer 21:34

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huigai S, Jingjing S, Zhiming X, Xinru L, Na LJCMMM (2022) Expression and clinical significance of serum Krüppel-like factor 7 (KLF7) in NSCLC patients. Comput Math Methods Med. https://doi.org/10.1155/2022/9270789

Article  Google Scholar 

Jian D, Wang Y, Jian L, Tang H, Rao L, Chen K et al (2020) METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications. Theranostics 10:8939–8956

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang H, Lv J (2021) MicroRNA-301a-3p increases oxidative stress, inflammation and apoptosis in ox-LDL-induced HUVECs by targeting KLF7. Exp Ther Med 21:569

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang L, Lan L, Qiu Y, Lu W, Wang W, Huang Y (2023) Target genes of N6-methyladenosine regulatory protein ALKBH5 are associated with prognosis of patients with lung adenocarcinoma. J Thorac Dis 15:3228–3236

Article  PubMed  PubMed Central  Google Scholar 

Le Z, Xin Z, Jing W, Yanwu J, Moxuan G, Yuyang Y et al (2022) METTL3 suppresses neuropathic pain via modulating N6-methyladenosine-dependent primary miR-150 processing. Cell Death Discov. https://doi.org/10.1038/s41420-022-00880-2

Article  PubMed  PubMed Central  Google Scholar 

Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N et al (2020) Ferroptosis: past, present and future. Cell Death Dis 11:88

Article  PubMed  PubMed Central  Google Scholar 

Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82:2215–2227

Article  CAS  PubMed  PubMed Central  Google Scholar 

Libby P (2021) The changing landscape of atherosclerosis. Nature 592:524–533

Article  CAS  PubMed  Google Scholar 

Liu Y, Zhang Z, Yang J, Wang J, Wu Y, Zhu R et al (2022) lncRNA ZFAS1 positively facilitates endothelial ferroptosis via miR-7-5p/ACSL4 Axis in diabetic retinopathy. Oxid Med Cell Longev 2022:9004738

PubMed  PubMed Central  Google Scholar 

Lv J, Li K, Yu H, Han J, Zhuang J, Yu R et al (2023) HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway. J Exp Clin Cancer Res 42:41

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H (2014) Atherosclerosis: process, indicators, risk factors and new hopes. Int J Prev Med 5:927–946

PubMed  PubMed Central  Google Scholar 

Rong J, Li C, Zhang Q, Zheng G, Fan W, Pan Z et al (2023) Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11. Pharm Biol 61:404–415

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M et al (2019) METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes. Autophagy 15:1419–1437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spaulding C, Krackhardt F, Bogaerts K, Urban P, Meis S, Morice MC et al (2023) Comparing a strategy of sirolimus-eluting balloon treatment to drug-eluting stent implantation in de novo coronary lesions in all-comers: design and rationale of the SELUTION DeNovo trial. Am Heart J 258:77–84

Article  CAS  PubMed  Google Scholar 

Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L et al (2022) Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis. Clin Immunol 245:109176

Article  CAS  PubMed  Google Scholar 

Tang D, Chen X, Kang R, Kroemer G (2021) Ferroptosis: molecular mechanisms and health implications. Cell Res 31:107–125

Article  CAS  PubMed  Google Scholar 

Terasaki M, Shibata K, Mori Y, Saito T, Matsui T, Ohara M et al (2023) SMTP-44D inhibits atherosclerotic plaque formation in Apolipoprotein-E null mice partly by suppressing the AGEs-RAGE axis. Int J Mol Sci 24:6505

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Chen R, Zhu X, Zhang X, Lian N (2022) METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m(6)A level of SIRT1 mRNA. Bone 168:116652

Article 

留言 (0)

沒有登入
gif