Baker MC, Sheth K, Lu R, Lu D, von Kaeppler EP, Bhat A, Felson DT, Robinson WH (2023) Increased risk of osteoarthritis in patients with atopic disease. Ann Rheum Dis 82:866–872

Article  PubMed  Google Scholar 

Bernabei I, So A, Busso N, Nasi S (2023) Cartilage calcification in osteoarthritis: mechanisms and clinical relevance. Nat Rev Rheumatol 19:10–27

Article  CAS  PubMed  Google Scholar 

Bhattacharjee M, Escobar Ivirico JL, Kan HM, Shah S, Otsuka T, Bordett R, Barajaa M, Nagiah N, Pandey R, Nair LS, Laurencin CT (2022) Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment. Proc Natl Acad Sci USA 119:e2120968119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carneiro DC, Araújo LT, Santos GC, Damasceno PKF, Vieira JL, Santos RRD, Barbosa JDV, Soares MBP (2023) Clinical trials with mesenchymal stem cell therapies for osteoarthritis: challenges in the regeneration of articular cartilage. Int J Mol Sci 24:9939

Article  PubMed  PubMed Central  Google Scholar 

Carrascal L, Nunez-Abades P, Ayala A, Cano M (2018) Role of melatonin in the inflammatory process and its therapeutic potential. Curr Pharm Des 24:1563–1588

Article  CAS  PubMed  Google Scholar 

Chae DS, Lee CY, Lee J, Seo HH, Choi CH, Lee S, Hwang KC (2018) Priming stem cells with protein kinase C activator enhances early stem cell-chondrocyte interaction by increasing adhesion molecules. Biol Res 51:41

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Ge Y, Zhou L, Li T, Yan B, Chen J, Huang J, Du W, Lv S, Tong P, Shan L (2021) Pain relief and cartilage repair by nanofat against osteoarthritis: preclinical and clinical evidence. Stem Cell Res Ther 12:477

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui L, Xu F, Jiang Z, Wang S, Li X, Ding Y, Zhang Y, Du M (2021) Melatonin regulates proliferation and apoptosis of endometrial stromal cells via MT1. Acta Biochim Biophys Sin (Shanghai) 53:1333–1341

Article  CAS  PubMed  Google Scholar 

Edemann-Callesen H, Andersen HK, Ussing A, Virring A, Jennum P, Debes NM, Laursen T, Baandrup L, Gade C, Dettmann J, Holm J, Krogh C, Birkefoss K, Tarp S, Händel MN (2023) Use of melatonin in children and adolescents with idiopathic chronic insomnia: a systematic review, meta-analysis, and clinical recommendation. EclinicalMedicine 61:102048

Article  PubMed  PubMed Central  Google Scholar 

Fan C, Feng J, Tang C, Zhang Z, Feng Y, Duan W, Zhai M, Yan Z, Zhu L, Feng L, Zhu H, Luo E (2020) Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage. Stem Cell Res Ther 11:442

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao B, Gao W, Wu Z, Zhou T, Qiu X, Wang X, Lian C, Peng Y, Liang A, Qiu J, Zhu Y, Xu C, Li Y, Su P, Huang D (2018) Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells. Stem Cell Res Ther 9:162

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo JY, Li F, Wen YB, Cui HX, Guo ML, Zhang L, Zhang YF, Guo YJ, Guo YX (2017) Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis. Oncotarget 8:55967–55983

Article  PubMed  PubMed Central  Google Scholar 

Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH (2018) The TLR4-PAR1 axis regulates bone marrow mesenchymal stromal cell survival and therapeutic capacity in experimental bacterial pneumonia. Stem Cells 36:796–806

Article  CAS  PubMed  Google Scholar 

Henrich D, Seebach C, Wilhelm K, Marzi I (2007) High dosage of simvastatin reduces TNF-alpha-induced apoptosis of endothelial progenitor cells but fails to prevent apoptosis induced by IL-1beta in vitro. J Surg Res 142:13–19

Article  CAS  PubMed  Google Scholar 

Hu Y, Xiong Y, Zha K, Tao R, Chen L, Xue H, Yan C, Lin Z, Endo Y, Cao F, Zhou W, Liu G (2023) Melatonin promotes BMSCs osteoblastic differentiation and relieves inflammation by suppressing the NF-κB pathways. Stem Cells In 2023:7638842

Google Scholar 

Huang CC, Chiou CH, Liu SC, Hu SL, Su CM, Tsai CH, Tang CH (2019) Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: implications for the treatment of rheumatoid arthritis. J Pineal Res 66:e12560

Article  PubMed  Google Scholar 

Jiang LB, Lee S, Wang Y, Xu QT, Meng DH, Zhang J (2016) Adipose-derived stem cells induce autophagic activation and inhibit catabolic response to pro-inflammatory cytokines in rat chondrocytes. Osteoarthr Cartil 24:1071–1081

Article  Google Scholar 

Ke C, Li H, Yang D, Ying H, Zhu H, Wang J, Xu J, Wang L (2022) Melatonin attenuates the progression of osteoarthritis in rats by inhibiting inflammation and related oxidative stress on the surface of knee cartilage. Orthop Surg 14:2230–2237

Article  PubMed  PubMed Central  Google Scholar 

Kim KI, Lee WS, Kim JH, Bae JK, Jin W (2022) Safety and efficacy of the intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritic knee: a 5-year follow-up study. Stem Cells Transl Med 11:586–596

Article  PubMed  PubMed Central  Google Scholar 

Kim KI, Lee MC, Lee JH, Moon YW, Lee WS, Lee HJ, Hwang SC, In Y, Shon OJ, Bae KC, Song SJ, Park KK, Kim JH (2023) Clinical efficacy and safety of the intra-articular injection of autologous adipose-derived mesenchymal stem cells for knee osteoarthritis: a phase iii, randomized, double-blind, placebo-controlled trial. Am J Sports Med 51:2243–2253

Article  PubMed  Google Scholar 

Lian C, Wu Z, Gao B, Peng Y, Liang A, Xu C, Liu L, Qiu X, Huang J, Zhou H, Cai Y, Su P, Huang D (2016) Melatonin reversed tumor necrosis factor-alpha-inhibited osteogenesis of human mesenchymal stem cells by stabilizing SMAD1 protein. J Pineal Res 61:317–327

Article  CAS  PubMed  Google Scholar 

Liang H, Yan Y, Sun W, Ma X, Su Z, Liu Z, Chen Y, Yu B (2023) Preparation of melatonin-loaded nanoparticles with targeting and sustained release function and their application in osteoarthritis. Int J Mol Sci 24:8740

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao N, Shi Y, Zhang C, Zheng Y, Wang Y, Zhao B, Zeng Y, Liu X, Liu J (2019) Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion. Stem Cell Res Ther 10:306

Article  PubMed  PubMed Central  Google Scholar 

Liao N, Shi Y, Wang Y, Liao F, Zhao B, Zheng Y, Zeng Y, Liu X, Liu J (2020) Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model. Stem Cell Res Ther 11:237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao N, Zhang D, Wu M, Yang H, Liu X, Song J (2021) Enhancing therapeutic effects and in vivo tracking of adipose tissue-derived mesenchymal stem cells for liver injury using bioorthogonal click chemistry. Nanoscale 13:1813–1822

Article  CAS  PubMed  Google Scholar 

Liu Y, Chen XQ, Wang F, Cheng B, Zhou G (2022) Melatonin relieves Th17/CD4-CD8- T cells inflammatory responses via nuclear-receptor dependent manner in peripheral blood of primary Sjögren’s syndrome. Int Immunopharmacol 109:108778

Article  CAS  PubMed  Google Scholar 

Liu Y, Wang F, Cheng B, Zhou G (2024) Melatonin improves salivary gland damage and hypofunction in pSS by inhibiting IL-6/STAT3 signaling through its receptor-dependent manner. Mol Immunol 169:10–27

Article  CAS  PubMed  Google Scholar 

Liu-Bryan R, Terkeltaub R (2015) Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol 11:35–44

Article  CAS  PubMed  Google Scholar 

Manferdini C, Maumus M, Gabusi E, Piacentini A, Filardo G, Peyrafitte JA, Jorgensen C, Bourin P, Fleury-Cappellesso S, Facchini A, Noël D, Lisignoli G (2013) Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. Arthritis Rheum 65:1271–1281

Article  CAS