Gordon JI (2012) Honor thy gut symbionts redux. Science 336:1251–3. https://doi.org/10.1126/science.1224686
Article CAS PubMed Google Scholar
Lynch SV, Pedersen O (2016) The human intestinal microbiome in health and disease. N Engl J Med 375:2369–2379. https://doi.org/10.1056/NEJMra1600266
Article CAS PubMed Google Scholar
Fan Y, Pedersen O (2021) Gut microbiota in human metabolic health and disease. Nat Rev Microbiol 19:55–71. https://doi.org/10.1038/s41579-020-0433-9
Article CAS PubMed Google Scholar
Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD et al (2019) What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms 7(1):14. https://doi.org/10.3390/microorganisms7010014
Article CAS PubMed PubMed Central Google Scholar
De Vadder F, Kovatcheva-Datchary P, Zitoun C, Duchampt A, Backhed F, Mithieux G (2016) Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis. Cell Metab 24:151–157. https://doi.org/10.1016/j.cmet.2016.06.013
Article CAS PubMed Google Scholar
Tremaroli V, Backhed F (2012) Functional interactions between the gut microbiota and host metabolism. Nature 489:242–249. https://doi.org/10.1038/nature11552
Article CAS PubMed Google Scholar
Ansaldo E, Farley TK, Belkaid Y (2021) Control of Immunity by the Microbiota. Annu Rev Immunol 39:449–479. https://doi.org/10.1146/annurev-immunol-093019-112348
Article CAS PubMed Google Scholar
Skelly AN, Sato Y, Kearney S, Honda K (2019) Mining the microbiota for microbial and metabolite-based immunotherapies. Nat Rev Immunol 19:305–23. https://doi.org/10.1038/s41577-019-0144-5
Article CAS PubMed Google Scholar
Ashida H, Ogawa M, Kim M, Mimuro H, Sasakawa C (2011) Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol 8:36–45. https://doi.org/10.1038/nchembio.741
Article CAS PubMed Google Scholar
Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K et al (2014) Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci USA 111:13145–13150. https://doi.org/10.1073/pnas.1412008111
Article CAS PubMed PubMed Central Google Scholar
Integrative HMP Research Network Consortium (2019) The integrative human microbiome project. Nature 569:641–648. https://doi.org/10.1038/s41586-019-1238-8
Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J et al (2019) Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature 569:655–662. https://doi.org/10.1038/s41586-019-1237-9
Article CAS PubMed PubMed Central Google Scholar
Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL et al (2012) Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 336:1325–1329. https://doi.org/10.1126/science.1222195
Article CAS PubMed PubMed Central Google Scholar
Hudault S, Guignot J, Servin AL (2001) Escherichia coli strains colonising the gastrointestinal tract protect germfree mice against Salmonella typhimurium infection. Gut 49:47–55. https://doi.org/10.1136/gut.49.1.47
Article CAS PubMed PubMed Central Google Scholar
Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA et al (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:569–573. https://doi.org/10.1126/science.1241165
Article CAS PubMed Google Scholar
Kim S, Shin YC, Kim TY, Kim Y, Lee YS et al (2021) Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development. Gut Microbes 13:1–20. https://doi.org/10.1080/19490976.2021.1892441
Article CAS PubMed Google Scholar
Dupraz L, Magniez A, Rolhion N, Richard ML, Da Costa G et al (2021) Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells. Cell Rep 36:109332. https://doi.org/10.1016/j.celrep.2021.109332
Article CAS PubMed Google Scholar
Rosser EC, Piper CJM, Matei DE, Blair PA, Rendeiro AF et al (2020) Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells. Cell Metab 31:837–51. https://doi.org/10.1016/j.cmet.2020.03.003
Article CAS PubMed PubMed Central Google Scholar
Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D et al (2019) Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T Cells. Immunity 51:285–297. https://doi.org/10.1016/j.immuni.2019.06.002
Article CAS PubMed Google Scholar
Wang RX, Lee JS, Campbell EL, Colgan SP (2020) Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin. Proc Natl Acad Sci USA 117:11648–11657. https://doi.org/10.1073/pnas.1917597117
Article CAS PubMed PubMed Central Google Scholar
Trompette A, Gollwitzer ES, Pattaroni C, Lopez-Mejia IC, Riva E et al (2018) Dietary fiber confers protection against flu by shaping Ly6c- patrolling monocyte hematopoiesis and CD8+ T cell metabolism. Immunity 48:992–1005. https://doi.org/10.1016/j.immuni.2018.04.022
Article CAS PubMed Google Scholar
Zhang D, Gao X, Li H, Borger DK, Wei Q et al (2022) The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow. Cell Stem Cell 29:232–247. https://doi.org/10.1016/j.stem.2021.12.009
Article CAS PubMed PubMed Central Google Scholar
van den Berg FF, van Dalen D, Hyoju SK, van Santvoort HC, Besselink MG et al (2021) Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate. Gut 70:915–927. https://doi.org/10.1136/gutjnl-2019-320430
Article CAS PubMed Google Scholar
Lee YS, Kim TY, Kim Y, Lee SH, Kim S et al (2018) Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development. Cell Host Microbe 24:833–846. https://doi.org/10.1016/j.chom.2018.11.002
Article CAS PubMed Google Scholar
Lee YS, Kim TY, Kim Y, Kim S, Lee SH et al (2021) Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells. Exp Mol Med 53:1319–1331. https://doi.org/10.1038/s12276-021-00667-y
Article CAS PubMed PubMed Central Google Scholar
McDonald B, Zucoloto AZ, Yu IL, Burkhard R, Brown K et al (2020) Programing of an intravascular immune firewall by the gut microbiota protects against pathogen dissemination during infection. Cell Host Microbe 28:660–668. https://doi.org/10.1016/j.chom.2020.07.014
Article CAS PubMed Google Scholar
Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ et al (2020) Succinate produced by intestinal microbes promotes specification of tuft cells to suppress ileal inflammation. Gastroenterology 159:2101–2115.
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