Dai, H. et al. The global burden of disease attributable to high body mass index in 195 countries and territories, 1990-2017: an analysis of the Global Burden of Disease Study. PLoS Med. 17, e1003198 (2020).
Article PubMed PubMed Central Google Scholar
Vaduganathan, M., Mensah, G. A., Turco, J. V., Fuster, V. & Roth, G. A. The Global Burden of Cardiovascular Diseases and Risk: a compass for future health. J. Am. Coll. Cardiol. 80, 2361–2371 (2022).
Sims, E. A. Are there persons who are obese, but metabolically healthy? Metabolism 50, 1499–1504 (2001).
Article CAS PubMed Google Scholar
Karelis, A. D., Brochu, M. & Rabasa-Lhoret, R. Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab. 30, 569–572 (2004).
Article CAS PubMed Google Scholar
Reaven, G. All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diab. Vasc. Dis. Res. 2, 105–112 (2005).
Stefan, N., Haring, H. U., Hu, F. B. & Schulze, M. B. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol. 1, 152–162 (2013).
Neeland, I. J., Poirier, P. & Despres, J. P. Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management. Circulation 137, 1391–1406 (2018).
Article PubMed PubMed Central Google Scholar
Stefan, N., Haring, H. U. & Schulze, M. B. Metabolically healthy obesity: the low-hanging fruit in obesity treatment? Lancet Diabetes Endocrinol. 6, 249–258 (2018).
Magkos, F. Metabolically healthy obesity: what’s in a name? Am. J. Clin. Nutr. 110, 533–539 (2019).
Schulze, M. B. Metabolic health in normal-weight and obese individuals. Diabetologia 62, 558–566 (2019).
Smith, G. I., Mittendorfer, B. & Klein, S. Metabolically healthy obesity: facts and fantasies. J. Clin. Invest. 129, 3978–3989 (2019).
Article PubMed PubMed Central Google Scholar
Bluher, M. Metabolically healthy obesity. Endocr. Rev. 41, bnaa004 (2020).
Article PubMed PubMed Central Google Scholar
Stefan, N. Causes, consequences, and treatment of metabolically unhealthy fat distribution. Lancet Diabetes Endocrinol. 8, 616–627 (2020).
Vague, J. Sexual differentiation; factor determining forms of obesity [French]. Presse Med. 55, 339 (1947).
Ruderman, N. B., Berchtold, P. & Schneider, S. Obesity-associated disorders in normal-weight individuals: some speculations. Int. J. Obes. 6, 151–157 (1982).
Manson, J. E. et al. A prospective study of obesity and risk of coronary heart disease in women. N. Engl. J. Med. 322, 882–889 (1990).
Article CAS PubMed Google Scholar
Ferrannini, E. et al. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J. Clin. Invest. 100, 1166–1173 (1997).
Article CAS PubMed PubMed Central Google Scholar
Katzmarzyk, P. T., Church, T. S., Janssen, I., Ross, R. & Blair, S. N. Metabolic syndrome, obesity, and mortality: impact of cardiorespiratory fitness. Diabetes Care 28, 391–397 (2005).
Meigs, J. B. et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J. Clin. Endocrinol. Metab. 91, 2906–2912 (2006).
Article CAS PubMed Google Scholar
McLaughlin, T., Abbasi, F., Lamendola, C. & Reaven, G. Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivity. Arch. Intern. Med. 167, 642–648 (2007).
Article CAS PubMed Google Scholar
Stefan, N. et al. Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168, 1609–1616 (2008).
Wildman, R. P. et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch. Intern. Med. 168, 1617–1624 (2008).
Fan, J., Song, Y., Chen, Y., Hui, R. & Zhang, W. Combined effect of obesity and cardio-metabolic abnormality on the risk of cardiovascular disease: a meta-analysis of prospective cohort studies. Int. J. Cardiol. 168, 4761–4768 (2013).
Zembic, A., Eckel, N., Stefan, N., Baudry, J. & Schulze, M. B. An empirically derived definition of metabolically healthy obesity based on risk of cardiovascular and total mortality. JAMA Netw. Open. 4, e218505 (2021).
Article PubMed PubMed Central Google Scholar
Petersen, M. C. et al. Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity. Cell Metab. 36, 745–761.e5 (2024).
Article CAS PubMed Google Scholar
[No authors listed] Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ. Tech. Rep. Ser. 894, 1–253 (2000).
Eckel, N., Meidtner, K., Kalle-Uhlmann, T., Stefan, N. & Schulze, M. B. Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis. Eur. J. Prev. Cardiol. 23, 956–966 (2016).
Yeh, T. L. et al. The relationship between metabolically healthy obesity and the risk of cardiovascular disease: a systematic review and meta-analysis. J. Clin. Med. 8, 1228 (2019).
Article PubMed PubMed Central Google Scholar
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) (Adult Treatment Panel III). JAMA 285, 2486–2497 (2001).
Alberti, K. G., Zimmet, P. & Shaw, J. Metabolic syndrome – a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet. Med. 23, 469–480 (2006).
Article CAS PubMed Google Scholar
Alberti, K. G. et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120, 1640–1645 (2009).
Article CAS PubMed Google Scholar
Caleyachetty, R. et al. Metabolically healthy obese and incident cardiovascular disease events among 3.5 million men and women. J. Am. Coll. Cardiol. 70, 1429–1437 (2017).
Eckel, N. et al. Transition from metabolic healthy to unhealthy phenotypes and association with cardiovascular disease risk across BMI categories in 90 257 women (the Nurses’ Health Study): 30 year follow-up from a prospective cohort study. Lancet Diabetes Endocrinol. 6, 714–724 (2018).
Commodore-Mensah, Y. et al. High burden of subclinical and cardiovascular disease risk in adults with metabolically healthy obesity: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 44, 1657–1663 (2021).
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