Warburg, O., Wind, F. & Negelein, E. The metabolism of tumors in the body. J. Gen. Physiol. 8, 519–530 (1927).
Article CAS PubMed PubMed Central Google Scholar
Hanahan, D. Hallmarks of cancer: new dimensions. Cancer Discov. 12, 31–46 (2022).
Article CAS PubMed Google Scholar
Stine, Z. E., Schug, Z. T., Salvino, J. M. & Dang, C. V. Targeting cancer metabolism in the era of precision oncology. Nat. Rev. Drug Discov. 21, 141–162 (2022).
Article CAS PubMed Google Scholar
Chen, R. et al. Effective prevention and treatment of acute leukemias in mice by activation of thermogenic adipose tissues. Adv. Sci. https://doi.org/10.1002/advs.202402332 (2024).
Cypess, A. M. Does activating brown fat contribute to important metabolic benefits in humans? Yes! J. Clin. Invest. 133, e175282 (2023).
Article CAS PubMed PubMed Central Google Scholar
Seki, T. et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature 608, 421–428 (2022).
Article CAS PubMed PubMed Central Google Scholar
Ye, H. et al. Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche. Cell Stem Cell 19, 23–37 (2016).
Article CAS PubMed PubMed Central Google Scholar
Heydt, Q. et al. Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence. Nat. Commun. 12, 5507 (2021).
Article CAS PubMed PubMed Central Google Scholar
Sun, X. et al. Mirabegron displays anticancer effects by globally browning adipose tissues. Nat. Commun. 14, 7610 (2023).
Article CAS PubMed PubMed Central Google Scholar
Ishay-Ronen, D. et al. Gain fat-lose metastasis: converting invasive breast cancer cells into adipocytes inhibits cancer metastasis. Cancer Cell 35, 17–32.e6 (2019).
留言 (0)