Cardiac autonomic neuropathy modified the association between obesity and hypoglycemia in type 2 diabetes

E. Ahmad, S. Lim, R. Lamptey, D.R. Webb, M.J. Davies, Type 2 diabetes. Lancet 400(10365), 1803–1820 (2022)

Article  PubMed  Google Scholar 

G.S.R. Group, D.M. Nathan, J.M. Lachin, A. Balasubramanyam, H.B. Burch, J.B. Buse et al. Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes. N. Engl. J. Med. 387(12), 1063–1074 (2022)

Article  Google Scholar 

D.E. Bonds, M.E. Miller, R.M. Bergenstal, J.B. Buse, R.P. Byington, J.A. Cutler et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 340, b4909 (2010)

Article  PubMed  PubMed Central  Google Scholar 

D.E. Bonds, E.M. Kurashige, R. Bergenstal, D. Brillon, M. Domanski, J.V. Felicetta et al. Severe hypoglycemia monitoring and risk management procedures in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am. J. Cardiol. 99(12A), 80i–89ii (2007)

Article  PubMed  Google Scholar 

J.S. Yun, S.H. Ko, Risk Factors and Adverse Outcomes of Severe Hypoglycemia in Type 2 Diabetes Mellitus. Diabetes Metab. J. 40(6), 423–432 (2016)

Article  PubMed  PubMed Central  Google Scholar 

J.S. Yun, Y.M. Park, K. Han, S.A. Cha, Y.B. Ahn, S.H. Ko, Association between BMI and risk of severe hypoglycaemia in type 2 diabetes. Diabetes Metab. 45(1), 19–25 (2019)

Article  PubMed  Google Scholar 

A.H. Mokdad, E.S. Ford, B.A. Bowman et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289(1), 76–79 (2003)

Article  PubMed  Google Scholar 

K. Jayanama, O. Theou, J. Godin, A. Mayo, L. Cahill, K. Rockwood, Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults. BMC Med. 20(1), 404 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C.J. Lavie, R.V. Milani, H.O. Ventura, Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J. Am. Coll. Cardiol. 53(21), 1925–1932 (2009)

Article  PubMed  Google Scholar 

D. Plecko, N. Bennett, J. Martensson, R. Bellomo, The obesity paradox and hypoglycemia in critically ill patients. Crit. Care 25(1), 378 (2021)

Article  PubMed  PubMed Central  Google Scholar 

V.L. Fisher, A.A. Tahrani, Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives. Diabetes Metab. Syndr. Obes. 10, 419–434 (2017)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S.M. Williams, A. Eleftheriadou, U. Alam, D.J. Cuthbertson, J.P.H. Wilding, Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review. Diabetes Ther. 10(6), 1995–2021 (2019)

Article  PubMed  PubMed Central  Google Scholar 

S. Williams, S.A. Raheim, M.I. Khan, U. Rubab, P. Kanagala, S.S. Zhao et al. Cardiac Autonomic Neuropathy in Type 1 and 2 Diabetes: Epidemiology, Pathophysiology, and Management. Clin. Ther. 44(10), 1394–1416 (2022)

Article  CAS  PubMed  Google Scholar 

A.D. Kaze, M.F. Yuyun, R.S. Ahima, M.R. Rickels, J.B. Echouffo-Tcheugui, Autonomic dysfunction and risk of severe hypoglycemia among individuals with type 2 diabetes. JCI Insight 7(22), e156334 (2022)

Article  PubMed  PubMed Central  Google Scholar 

A.S. Group, J.B. Buse, J.T. Bigger, R.P. Byington, L.S. Cooper, W.C. Cushman et al. Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. Am. J. Cardiol. 99(12A), 21i–33i (2007)

Google Scholar 

A.R. Cobitz, P. Ambery, Effects of Cardiac Autonomic Dysfunction on Mortality Risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Diabetes Care 32(5), e58 (2009)

Article  PubMed  Google Scholar 

A.D. Kaze, M.F. Yuyun, S. Erqou, G.C. Fonarow, J.B. Echouffo-Tcheugui, Cardiac autonomic neuropathy and risk of incident heart failure among adults with type 2 diabetes. Eur. J. Heart Fail 24(4), 634–641 (2022)

Article  PubMed  Google Scholar 

M. Jaiswal, K. McKeon, N. Comment, J. Henderson, S. Swanson, C. Plunkett et al. Association Between Impaired Cardiovascular Autonomic Function and Hypoglycemia in Patients With Type 1 Diabetes. Diabetes Care 37(9), 2616–2621 (2014)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Meyer, R. Grossmann, A. Mitrakou et al. Effects of autonomic neuropathy on counterregulation and awareness of hypoglycemia in type 1 diabetic patients. Diabetes Care 21(11), 1960–1966 (1998)

Article  CAS  PubMed  Google Scholar 

S.P. Lee, L. Yeoh, N.D. Harris et al. Influence of autonomic neuropathy on QTc interval lengthening during hypoglycemia in type 1 diabetes. Diabetes 53(6), 1535–1542 (2004)

Article  CAS  PubMed  Google Scholar 

J.S. Yun, J.H. Kim, K.H. Song, Y.B. Ahn, K.H. Yoon, K.D. Yoo et al. Cardiovascular autonomic dysfunction predicts severe hypoglycemia in patients with type 2 diabetes: a 10-year follow-up study. Diabetes Care 37(1), 235–241 (2014)

Article  CAS  PubMed  Google Scholar 

Y. Tang, H. Shah, C.R. Bueno Junior, X. Sun, J. Mitri, M. Sambataro et al. Intensive Risk Factor Management and Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: The ACCORD Trial. Diabetes Care 44(1), 164–173 (2021)

Article  PubMed  Google Scholar 

A.D. Kaze, M.F. Yuyun, S. Erqou, G.C. Fonarow, J.B. Echouffo-Tcheugui, Severe Hypoglycemia and Incidence of QT Interval Prolongation Among Adults With Type 2 Diabetes. J. Clin. Endocrinol. Metab. 107(7), e2743–e2750 (2022)

Article  PubMed  PubMed Central  Google Scholar 

M.E. Miller, D.E. Bonds, H.C. Gerstein, E.R. Seaquist, R.M. Bergenstal, J. Calles-Escandon et al. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ 340, b5444 (2010)

Article  PubMed  PubMed Central  Google Scholar 

S. Zoungas, A. Patel, J. Chalmers et al. Severe hypoglycemia and risks of vascular events and death. N. Engl. J. Med 363(15), 1410–1418 (2010)

Article  CAS  PubMed  Google Scholar 

T.B. Horwich, G.C. Fonarow, A.L. Clark, Obesity and the Obesity Paradox in Heart Failure. Prog. Cardiovasc Dis. 61(2), 151–156 (2018)

Article  PubMed  Google Scholar 

V. Hainer, I. Aldhoon-Hainerova, Obesity paradox does exist. Diabetes Care 36(Suppl 2), S276–S281 (2013)

Article  PubMed  PubMed Central  Google Scholar 

D.E. Amundson, S. Djurkovic, G.N. Matwiyoff, The obesity paradox. Crit. Care Clin. 26(4), 583–596 (2010)

Article  PubMed  Google Scholar 

A.P. Kong, X. Yang, A. Luk et al. Severe hypoglycemia identifies vulnerable patients with type 2 diabetes at risk for premature death and all-site cancer: the Hong Kong diabetes registry. Diabetes Care 37(4), 1024–1031 (2014)

Article  CAS  PubMed  Google Scholar 

L. Perego, P. Pizzocri, D. Corradi, F. Maisano, M. Paganelli, P. Fiorina et al. Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J. Clin. Endocrinol. Metab. 90(7), 4087–4093 (2005)

Article  CAS  PubMed  Google Scholar 

Y.R. Lai, M.H. Chen, W.C. Lin, W.C. Chiu, B.C. Cheng, J.F. Chen et al. Leptin mediate central obesity on the severity of cardiovascular autonomic neuropathy in well-controlled type 2 diabetes and prediabetes. J. Transl. Med. 18(1), 396 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Kurajoh, H. Koyama, M. Kadoya, M. Naka, A. Miyoshi, A. Kanzaki et al. Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study. Cardiovasc Diabetol. 14, 117 (2015)

留言 (0)

沒有登入
gif