Yoon JH, Park NH, Kang YE, Ahn YC, Lee EJ, Son CG. The demographic features of fatigue in the general population worldwide: a systematic review and meta-analysis. Front Public Health. 2023;11:1192121. doi:https://doi.org/10.3389/fpubh.2023.1192121

PubMed  PubMed Central  Google Scholar 

Meng H, Hale L, Friedberg F. Prevalence and predictors of fatigue in middle-aged and older adults: evidence from the health and retirement study. J Am Geriatr Soc. 2010;58:2033–2034. doi:https://doi.org/10.1111/j.1532-5415.2010.03088.x

PubMed  PubMed Central  Google Scholar 

Moreh E, Jacobs JM, Stessman J. Fatigue, function, and mortality in older adults. J Gerontol A Biol Sci Med Sci. 2010;65:887–895. doi:https://doi.org/10.1093/gerona/glq064

PubMed  Google Scholar 

Avlund K. Fatigue in older adults: an early indicator of the aging process?. Aging Clin Exp Res. 2010;22:100–115. doi:https://doi.org/10.1007/bf03324782

PubMed  Google Scholar 

Zengarini E, Ruggiero C, Pérez-Zepeda MU, et al. Fatigue: Relevance and implications in the aging population. Exp Gerontol. 2015;70:78–83. doi:https://doi.org/10.1016/j.exger.2015.07.011

PubMed  Google Scholar 

Nicholson K, Stewart M, Thind A. Examining the symptom of fatigue in primary care: a comparative study using electronic medical records. J Innov Health Inform. 2015;22:235–243. doi:https://doi.org/10.14236/jhi.v22i1.91

PubMed  Google Scholar 

LaSorda KR, Gmelin T, Kuipers AL, et al. Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2020;75:e81–e88. doi:https://doi.org/10.1093/gerona/glz288

PubMed  Google Scholar 

Bensing JM, Hulsman RL, Schreurs KM. Gender differences in fatigue: biopsychosocial factors relating to fatigue in men and women. Med Care. 1999;37:1078–1083. doi:https://doi.org/10.1097/00005650-199910000-00011

CAS  PubMed  Google Scholar 

Engberg I, Segerstedt J, Waller G, Wennberg P, Eliasson M. Fatigue in the general population- associations to age, sex, socioeconomic status, physical activity, sitting time and self-rated health: the northern Sweden MONICA study 2014. BMC Public Health. 2017;17:654. doi:https://doi.org/10.1186/s12889-017-4623-y

PubMed  PubMed Central  Google Scholar 

Simonsick EM, Glynn NW, Jerome GJ, Shardell M, Schrack JA, Ferrucci L. Fatigued, but Not Frail: Perceived Fatigability as a Marker of Impending Decline in Mobility-Intact Older Adults. J Am Geriatr Soc. 2016;64:1287–1292. doi:https://doi.org/10.1111/jgs.14138

PubMed  PubMed Central  Google Scholar 

Knoop V, Cloots B, Costenoble A, et al. Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis. Ageing Res Rev. 2021;67:101261. doi:https://doi.org/10.1016/j.arr.2021.101261

CAS  PubMed  Google Scholar 

McCrone P, Darbishire L, Ridsdale L, Seed P. The economic cost of chronic fatigue and chronic fatigue syndrome in UK primary care. Psychol Med. 2003;33:253–261. doi:https://doi.org/10.1017/s0033291702006980

CAS  PubMed  Google Scholar 

Painter P, Stewart AL, Carey S. Physical functioning: definitions, measurement, and expectations. Adv Ren Replace Ther. 1999;6:110–123. doi:https://doi.org/10.1016/s1073-4449(99)70028-2

CAS  PubMed  Google Scholar 

Mueller-Schotte S, Bleijenberg N, van der Schouw YT, Schuurmans MJ. Fatigue as a long-term risk factor for limitations in instrumental activities of daily living and/or mobility performance in older adults after 10 years. Clin Interv Aging. 2016;11:1579–1587. doi:https://doi.org/10.2147/cia.S116741

PubMed  PubMed Central  Google Scholar 

Vestergaard S, Nayfield SG, Patel KV, et al. Fatigue in a representative population of older persons and its association with functional impairment, functional limitation, and disability. J Gerontol A Biol Sci Med Sci. 2009;64:76–82. doi:https://doi.org/10.1093/gerona/gln017

PubMed  Google Scholar 

Boter H, Mänty M, Hansen AM, Hortobágyi T, Avlund K. Self-reported fatigue and physical function in late mid-life. J Rehabil Med. 2014;46:684–690. doi:https://doi.org/10.2340/16501977-1814

PubMed  Google Scholar 

Mänty M, de Leon CF, Rantanen T, et al. Mobility-related fatigue, walking speed, and muscle strength in older people. J Gerontol A Biol Sci Med Sci. 2012;67:523–529. doi:https://doi.org/10.1093/gerona/glr183

PubMed  Google Scholar 

Mänty M, Ekmann A, Thinggaard M, Christensen K, Avlund K. Indoor mobility-related fatigue and muscle strength in nonagenarians: a prospective longitudinal study. Aging Clin Exp Res. 2014;26:39–46. doi:https://doi.org/10.1007/s40520-013-0178-7

PubMed  Google Scholar 

Alcazar J, Rodriguez-Lopez C, Delecluse C, Thomis M, Van Roie E. Ten-year longitudinal changes in muscle power, force, and velocity in young, middle-aged, and older adults. J Cachexia Sarcopenia Muscle. 2023;14:1019–1032. doi:https://doi.org/10.1002/jcsm.13184

PubMed  PubMed Central  Google Scholar 

Letnes JM, Nes BM, Wisløff U. Age-related decline in peak oxygen uptake: Cross-sectional vs. longitudinal findings. A review. Int J Cardiol Cardiovasc Risk Prev. 2023;16:200171. doi:https://doi.org/10.1016/j.ijcrp.2023.200171

PubMed  PubMed Central  Google Scholar 

de Souto Barreto P, Guyonnet S, Ader I, et al. The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System. J Frailty Aging. 2021;10:86–93. doi:https://doi.org/10.14283/jfa.2020.18

CAS  PubMed  Google Scholar 

Guyonnet S, Rolland Y, Takeda C, et al. The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort). J Frailty Aging. 2021;10:110–120. doi:https://doi.org/10.14283/jfa.2020.38

CAS  PubMed  Google Scholar 

Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. PLoS Med. 2007;4:e297. doi:https://doi.org/10.1371/journal.pmed.0040297

PubMed  PubMed Central  Google Scholar 

Cella D, Choi SW, Condon DM, et al. PROMIS(®) Adult Health Profiles: Efficient Short-Form Measures of Seven Health Domains. Value Health. 2019;22:537–544. doi:https://doi.org/10.1016/j.jval.2019.02.004

PubMed  PubMed Central  Google Scholar 

Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85–94. doi:https://doi.org/10.1093/geronj/49.2.m85

CAS  PubMed  Google Scholar 

Rikli RE, Jones CJ. Development and validation of criterion-referenced clinically relevant fitness standards for maintaining physical independence in later years. Gerontologist. 2013;53:255–267. doi:https://doi.org/10.1093/geront/gns071

PubMed  Google Scholar 

Drouin JM, Valovich-mcLeod TC, Shultz SJ, Gansneder BM, Perrin DH. Reliability and validity of the Biodex system 3 pro isokinetic dynamometer velocity, torque and position measurements. Eur J Appl Physiol. 2004;91:22–29. doi:https://doi.org/10.1007/s00421-003-0933-0

PubMed  Google Scholar 

Brown LE. Isokinetics in human performance. 2000. Human Kinetics, Champaign, IL

Google Scholar 

Karlman Wasserman JEH, Darryl Y Sue, William W Stringer, Kathy E Sietsema, Xing-Guo Sun, Brian J Whipp. Principles of exercise testing and interpretation including pathophysiology and clinical applications. 2011. Lippincott Williams and Wilkins, Baltimore, Maryland

Google Scholar 

Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383. doi:https://doi.org/10.1016/0021-9681(87)90171-8

CAS  PubMed  Google Scholar 

Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. the index of ADL: A standardized measure of biological and psychosocial function. Jama. 1963;185:914–919. doi:https://doi.org/10.1001/jama.1963.03060120024016

CAS  PubMed  Google Scholar 

Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–186.

CAS  PubMed  Google Scholar 

Folstein MF, Folstein SE, McHugh PR. «Mini-mental state». DiscreteContentObjectOnlineMediaObjects="NoA practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198. doi:https://doi.org/10.1016/0022-3956(75)90026-6

CAS  PubMed  Google Scholar 

Cooper R, Popham M, Santanasto AJ, Hardy R, Glynn NW, Kuh D. Are BMI and inflammatory markers independently associated with physical fatigability in old age?. Int J Obes (Lond). 2019;43:832–841. doi:https://doi.org/10.1038/s41366-018-0087-0

CAS  PubMed  Google Scholar 

Wanigatunga AA, Simonsick EM, Zipunnikov V, et al. Perceived Fatigability and Objective Physical Activity in Mid- to Late-Life. J Gerontol A Biol Sci Med Sci. 2018;73:630–635. doi:https://doi.org/10.1093/gerona/glx181

PubMed  Google Scholar 

Junghaenel DU, Christodoulou C, Lai JS, Stone AA. Demographic correlates of fatigue in the US general population: results from the patient-reported outc