Lanktree MB, Haghighi A, Guiard E, Iliuta IA, Song X, Harris PC, et al. Prevalence estimates of polycystic kidney and liver disease by population sequencing. J Am Soc Nephrol. 2018;29:2593–600.
Article CAS PubMed PubMed Central Google Scholar
Willey CJ, Blais JD, Hall AK, Krasa HB, Makin AJ, Czerwiec FS. Prevalence of autosomal dominant polycystic kidney disease in the European Union. Nephrol Dial Transpl. 2017;32:1356–63.
Chapin HC, Caplan MJ. The cell biology of polycystic kidney disease. J Cell Biol. 2010;191:701–10.
Article CAS PubMed PubMed Central Google Scholar
Bergmann C, Guay-Woodford LM, Harris PC, Horie S, Peters DJM, Torres VE. Polycystic kidney disease. Nat Rev Dis Prim. 2018;4:50.
Cornec-Le Gall E, Alam A, Perrone RD. Autosomal dominant polycystic kidney disease. Lancet. 2019;393:919–35.
Rinschen MM, Schermer B, Benzing T. Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again. J Am Soc Nephrol. 2014;25:1140–7.
Article CAS PubMed PubMed Central Google Scholar
Wilson PD. Therapeutic targets for polycystic kidney disease. Expert Opin Ther Targets. 2016;20:35–45.
Article CAS PubMed Google Scholar
Fenton RA, Brond L, Nielsen S, Praetorius J. Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney. Am J Physiol Ren Physiol. 2007;293:F748–F760.
Wang X, Wu Y, Ward CJ, Harris PC, Torres VE. Vasopressin directly regulates cyst growth in polycystic kidney disease. J Am Soc Nephrol. 2008;19:102–8.
Article CAS PubMed PubMed Central Google Scholar
Belibi FA, Reif G, Wallace DP, Yamaguchi T, Olsen L, Li H, et al. Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells. Kidney Int. 2004;66:964–73.
Article CAS PubMed Google Scholar
Sun Y, Liu Z, Cao X, Lu Y, Mi Z, He C, et al. Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. Sci Adv. 2019;5:eaaw3593.
Article CAS PubMed PubMed Central Google Scholar
Torres VE, Harris PC. Strategies targeting cAMP signaling in the treatment of polycystic kidney disease. J Am Soc Nephrol. 2014;25:18–32.
Article CAS PubMed Google Scholar
Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Grantham JJ, Higashihara E, et al. Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med. 2012;367:2407–18.
Article CAS PubMed PubMed Central Google Scholar
Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Koch G, et al. Tolvaptan in later-stage autosomal dominant polycystic kidney disease. N Engl J Med. 2017;377:1930–42.
Article CAS PubMed Google Scholar
Wang X, Constans MM, Chebib FT, Torres VE, Pellegrini L. Effect of a vasopressin V2 receptor antagonist on polycystic kidney disease development in a rat model. Am J Nephrol. 2019;49:487–93.
Article CAS PubMed Google Scholar
Aihara M, Fujiki H, Mizuguchi H, Hattori K, Ohmoto K, Ishikawa M, et al. Tolvaptan delays the onset of end-stage renal disease in a polycystic kidney disease model by suppressing increases in kidney volume and renal injury. J Pharmacol Exp Ther. 2014;349:258–67.
Hammond S, Gibson A, Jaruthamsophon K, Roth S, Mosedale M, Naisbitt DJ. Shedding light on drug-induced liver injury: activation of T cells from drug naive human donors with tolvaptan and a hydroxybutyric acid metabolite. Toxicol Sci. 2021;179:95–107.
Cao X, Wang P, Yuan H, Zhang H, He Y, Fu K, et al. Benzodiazepine derivatives as potent vasopressin V2 receptor antagonists for the treatment of autosomal dominant kidney disease. J Med Chem. 2022;65:9295–311.
Article CAS PubMed Google Scholar
Cao X, Wang P, Zhao W, Yuan H, Hu H, Chen T, et al. Structure-affinity and structure-kinetic relationship studies of benzodiazepine derivatives for the development of efficacious vasopressin V2 receptor antagonists. J Med Chem. 2023;66:3621–34.
Article CAS PubMed Google Scholar
Ogawa H, Yamashita H, Kondo K, Yamamura Y, Miyamoto H, Kan K, et al. Orally active, nonpeptide vasopressin V2 receptor antagonists: a novel series of 1-[4-(benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and related compounds. J Med Chem. 1996;39:3547–55.
Dror RO, Pan AC, Arlow DH, Borhani DW, Maragakis P, Shan Y, et al. Pathway and mechanism of drug binding to G-protein-coupled receptors. Proc Natl Acad Sci USA. 2011;108:13118–23.
Article CAS PubMed PubMed Central Google Scholar
Zhou F, Ye C, Ma X, Yin W, Croll TI, Zhou Q, et al. Molecular basis of ligand recognition and activation of human V2 vasopressin receptor. Cell Res. 2021;31:929–31.
Article CAS PubMed PubMed Central Google Scholar
Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, et al. Cryo-EM structure of the AVP-vasopressin receptor 2-Gs signaling complex. Cell Res. 2021;31:932–4.
Article CAS PubMed PubMed Central Google Scholar
Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, et al. Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex. Sci Adv. 2021;7:eabg5628.
Article CAS PubMed PubMed Central Google Scholar
Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, et al. Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex. Sci Adv. 2022;8:eabo7761.
Article CAS PubMed PubMed Central Google Scholar
Juan A, Ballesteros HW. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods Neurosci. 1995;25:366–428.
Song Y, DiMaio F, Wang RY, Kim D, Miles C, Brunette T, et al. High-resolution comparative modeling with RosettaCM. Structure. 2013;21:1735–42.
Article CAS PubMed Google Scholar
Jo S, Kim T, Iyer VG, Im W. CHARMM-GUI: a web-based graphical user interface for CHARMM. J Comput Chem. 2008;29:1859–65.
Article CAS PubMed Google Scholar
Lee J, Hitzenberger M, Rieger M, Kern NR, Zacharias M, Im W. CHARMM-GUI supports the Amber force fields. J Chem Phys. 2020;153:035103.
Article CAS PubMed Google Scholar
Lee J, Cheng X, Swails JM, Yeom MS, Eastman PK, Lemkul JA, et al. CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field. J Chem Theory Comput. 2016;12:405–13.
Article CAS PubMed Google Scholar
Lomize MA, Pogozheva ID, Joo H, Mosberg HI, Lomize AL. OPM database and PPM web server: resources for positioning of proteins in membranes. Nucleic Acids Res. 2012;40:D370–D376.
Article CAS PubMed Google Scholar
Jorgensen WL, Chandrasekhar J, Madura JD, Impey RW, Klein ML. Comparison of simple potential functions for simulating liquid water. J
留言 (0)