Desilles JP, Rouchaud A, Labreuche J, Meseguer E, Laissy JP, Serfaty JM, et al. Blood-brain barrier disruption is associated with increased mortality after endovascular therapy. Neurology. 2013;80:844–51.

Article  PubMed  Google Scholar 

Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, et al. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med. 2015;212:1529–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Won S, Sayeed I, Peterson BL, Wali B, Kahn JS, Stein DG. Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via vitamin D receptor-mediated NF-kappaB signaling pathways. PLoS One. 2015;10:e0122821.

Article  PubMed  PubMed Central  Google Scholar 

Chen B, Friedman B, Cheng Q, Tsai P, Schim E, Kleinfeld D, et al. Severe blood-brain barrier disruption and surrounding tissue injury. Stroke. 2009;40:e666–74.

Article  PubMed  PubMed Central  Google Scholar 

Wang YP, Du WH, Hu XY, Yu X, Guo C, Jin XC, et al. Targeting the blood-brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays. Acta Pharmaceutica Sin B. 2023;13:4667–87.

Article  Google Scholar 

Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014;509:507–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, et al. Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis. Neuron. 2017;94:581–94. e5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao C, Ma J, Wang Z, Li H, Shen H, Li X, et al. Mfsd2a attenuates blood-brain barrier disruption after sub-arachnoid hemorrhage by inhibiting caveolae-mediated transcellular transport in rats. Transl Stroke Res. 2020;11:1012–27.

Article  PubMed  Google Scholar 

Yang YR, Xiong XY, Liu J, Wu LR, Zhong Q, Zhou K, et al. Mfsd2a (Major facilitator superfamily domain containing 2a) attenuates intracerebral hemorrhage-induced blood-brain barrier disruption by inhibiting vesicular transcytosis. J Am Heart Assoc. 2017;6:e005811.

Article  PubMed  PubMed Central  Google Scholar 

Eser Ocak P, Ocak U, Sherchan P, Gamdzyk M, Tang J, Zhang JH. Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury. Exp Neurol. 2020;326:113203.

Article  CAS  PubMed  Google Scholar 

Hussain B, Fang C, Huang X, Feng Z, Yao Y, Wang Y, et al. Endothelial beta-catenin deficiency causes blood-brain barrier breakdown via enhancing the paracellular and transcellular permeability. Front Mol Neurosci. 2022;15:895429.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong P, Zhang Z, Zou C, Tian Q, Chen X, Hong M, et al. Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury. Behav Brain Res. 2019;356:8–17.

Article  CAS  PubMed  Google Scholar 

Hu X, Dong J, Geng P, Sun Y, Du W, Zhao X, et al. Nicotine treatment ameliorates blood-brain barrier damage after acute ischemic stroke by regulating endothelial scaffolding protein Pdlim5. Transl Stroke Res. 2024;15:672–87.

Article  CAS  PubMed  Google Scholar 

Elbediwy A, Vanyai H, Diaz-de-la-Loza MD, Frith D, Snijders AP, Thompson BJ. Enigma proteins regulate YAP mechanotransduction. J Cell Sci. 2018;131:jcs221788.

Article  PubMed  PubMed Central  Google Scholar 

Carraway KL, Burden SJ. Neuregulins and their receptors. Curr Opin Neurobiol. 1995;5:606–12.

Article  CAS  PubMed  Google Scholar 

Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, et al. Neuregulin-1 signaling in brain endothelial cells. J Cereb Blood Flow Metab. 2009;29:39–43.

Article  CAS  PubMed  Google Scholar 

Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, et al. Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury. Transl Stroke Res. 2012;3:S119–24.

Article  PubMed  PubMed Central  Google Scholar 

Ji Y, Teng L, Zhang R, Sun J, Guo Y. NRG-1beta exerts neuroprotective effects against ischemia reperfusion-induced injury in rats through the JNK signaling pathway. Neuroscience. 2017;362:13–24.

Article  CAS  PubMed  Google Scholar 

Xu Z, Ford BD. Upregulation of erbB receptors in rat brain after middle cerebral arterial occlusion. Neurosci Lett. 2005;375:181–6.

Article  CAS  PubMed  Google Scholar 

Qian H, Dou Z, Ruan W, He P, Zhang JH, Yan F. ErbB4 preserves blood-brain barrier integrity via the YAP/PIK3CB pathway after subarachnoid hemorrhage in rats. Front Neurosci. 2018;12:492.

Article  PubMed  PubMed Central  Google Scholar 

Li F, Liu WC, Wang Q, Sun Y, Wang H, Jin X. NG2-glia cell proliferation and differentiation by glial growth factor 2 (GGF2), a strategy to promote functional recovery after ischemic stroke. Biochem Pharmacol. 2020;171:113720.

Article  CAS  PubMed  Google Scholar 

Wu L, Ramirez SH, Andrews AM, Leung W, Itoh K, Wu J, et al. Neuregulin1-beta decreases interleukin-1beta-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem. 2016;136:250–7.

Article  CAS  PubMed  Google Scholar 

Wu L, Walas S, Leung W, Sykes DB, Wu J, Lo EH, et al. Neuregulin1-beta decreases IL-1beta-induced neutrophil adhesion to human brain microvascular endothelial cells. Transl Stroke Res. 2014;6:116–24.

Article  PubMed  PubMed Central  Google Scholar 

Ryzhov S, Matafonov A, Galindo CL, Zhang Q, Tran TL, Lenihan DJ, et al. ERBB signaling attenuates proinflammatory activation of nonclassical monocytes. Am J Physiol Heart Circ Physiol. 2017;312:H907–H18.

Article  PubMed  PubMed Central  Google Scholar 

Dimayuga FO, Ding Q, Keller JN, Marchionni MA, Seroogy KB, Bruce-Keller AJ. The neuregulin GGF2 attenuates free radical release from activated microglial cells. J Neuroimmunol. 2003;136:67–74.

Article  CAS  PubMed  Google Scholar 

Chen S, Sun Y, Li F, Zhang X, Hu X, Zhao X, et al. Modulation of alpha7nAchR by melatonin alleviates ischemia and reperfusion-compromised integrity of blood-brain barrier through inhibiting hmgb1-mediated microglia activation and crtc1-mediated neuronal loss. Cell Mol Neurobiol. 2022;42:2407–22.

Article  CAS  PubMed  Google Scholar 

Liu Y, Liu WC, Sun Y, Shen X, Wang X, Shu H, et al. Normobaric hyperoxia extends neuro- and vaso-protection of N-acetylcysteine in transient focal ischemia. Mol Neurobiol. 2017;54:3418–27.

Article  CAS  PubMed  Google Scholar 

Wang X, Liu Y, Sun Y, Liu W, Jin X. Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO. J Neurol Sci. 2016;363:63–8.

Article  CAS  PubMed  Google Scholar 

Shu H, Wang M, Song M, Sun Y, Shen X, Zhang J, et al. Acute nicotine treatment alleviates LPS-induced impairment of fear memory reconsolidation through AMPK activation and CRTC1 upregulation in hippocampus. Int J Neuropsychopharmacol. 2020;23:687–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Wang X, Zhang X, Chen S, Sun Y, Liu W, et al. D1 receptor-mediated endogenous tPA upregulation contributes to blood-brain barrier injury after acute ischaemic stroke. J Cell Mol Med. 2020;24:9255–66.