Prioritization of drug targets for thyroid cancer: a multi-omics Mendelian randomization study

L. Boucai, M. Zafereo, M. Cabanillas, Thyroid cancer: a review. JAMA 331, 425–435 (2024)

Article  CAS  PubMed  Google Scholar 

D. Chen, B. Lang, D. McLeod, K. Newbold, M. Haymart, Thyroid cancer. Lancet 401, 1531–1544 (2023)

Article  PubMed  Google Scholar 

M. Schlumberger, S. Leboulleux, Current practice in patients with differentiated thyroid cancer. Nat. Rev. Endocrinol. 17, 176–188 (2021)

Article  CAS  PubMed  Google Scholar 

P. Santhanam, P.W. Ladenson, Surveillance for differentiated thyroid cancer recurrence. Endocrinol. Metab. Clin. North Am. 48, 239–252 (2019)

Article  PubMed  Google Scholar 

N. Rajan, T. Khanal, M.D. Ringel, Progression and dormancy in metastatic thyroid cancer: concepts and clinical implications. Endocrine 70, 24–35 (2020)

Article  CAS  PubMed  Google Scholar 

L. Zhang, Q. Feng, J. Wang, Z. Tan, Q. Li, M. Ge, Molecular basis and targeted therapy in thyroid cancer: Progress and opportunities. Biochimica et. Biophysica Acta Rev. Cancer 1878, 188928 (2023)

Article  CAS  Google Scholar 

Y. Zhang, Z. Xing, T. Liu, M. Tang, L. Mi, J. Zhu, W. Wu, T. Wei, Targeted therapy and drug resistance in thyroid cancer. Eur. J. Med. Chem. 238, 114500 (2022)

Article  CAS  PubMed  Google Scholar 

E. Birney, Mendelian randomization. Csh Perspect. Med 12, a41302 (2021)

Google Scholar 

G.D. Smith, D.A. Lawlor, R. Harbord, N. Timpson, I. Day, S. Ebrahim, Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med. 4, e352 (2007)

Article  PubMed  Google Scholar 

A.F. McRae, R.E. Marioni, S. Shah, J. Yang, J.E. Powell, S.E. Harris, J. Gibson, A.K. Henders, L. Bowdler, J.N. Painter et al. Identification of 55,000 replicated DNA methylation QTL. Sci. Rep. Uk 8, 17605 (2018)

Article  Google Scholar 

U. Võsa, A. Claringbould, H. Westra, M.J. Bonder, P. Deelen, B. Zeng, H. Kirsten, A. Saha, R. Kreuzhuber, S. Yazar et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat. Genet. 53, 1300–1310 (2021)

Article  PubMed  Google Scholar 

B.B. Sun, J. Chiou, M. Traylor, C. Benner, Y. Hsu, T.G. Richardson, P. Surendran, A. Mahajan, C. Robins, S.G. Vasquez-Grinnell et al. Plasma proteomic associations with genetics and health in the UK Biobank. Nature 622, 329–338 (2023)

Article  CAS  PubMed  Google Scholar 

M.I. Kurki, J. Karjalainen, P. Palta, T.P. Sipilä, K. Kristiansson, K.M. Donner, M.P. Reeve, H. Laivuori, M. Aavikko, M.A. Kaunisto et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613, 508–518 (2023)

Article  CAS  PubMed  Google Scholar 

L. Jiang, Z. Zheng, H. Fang, J. Yang, A generalized linear mixed model association tool for biobank-scale data. Nat. Genet 53, 1616–1621 (2021)

Article  CAS  PubMed  Google Scholar 

C. Finan, A. Gaulton, F. Kruger, R. Lumbers, T. Shah, J. Engmann, L. Galver, R. Kelley, A. Karlsson, R. Santos et al. The druggable genome and support for target identification and validation in drug development. Sci. Transl. Med. 9, g1166 (2017)

Article  Google Scholar 

R. Insolera, W. Shao, R. Airik, F. Hildebrandt, S.H. Shi, SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex. Neuron 83, 805–822 (2014)

Article  CAS  PubMed  Google Scholar 

E.A. Otto, T.W. Hurd, R. Airik, M. Chaki, W. Zhou, C. Stoetzel, S.B. Patil, S. Levy, A.K. Ghosh, C.A. Murga-Zamalloa et al. Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat. Genet 42, 840–850 (2010)

Article  CAS  PubMed  Google Scholar 

E. Schaefer, A. Zaloszyc, J. Lauer, M. Durand, F. Stutzmann, Y. Perdomo-Trujillo, C. Redin, V. Bennouna Greene, A. Toutain, L. Perrin et al. Mutations in SDCCAG8/NPHP10 cause bardet-biedl syndrome and are associated with penetrant renal disease and absent polydactyly. Mol. Syndromol. 1, 273–281 (2011)

Article  CAS  PubMed  Google Scholar 

R. Airik, G.G. Slaats, Z. Guo, A.C. Weiss, N. Khan, A. Ghosh, T.W. Hurd, S. Bekker-Jensen, J.M. Schroder, S.J. Elledge et al. Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling. J. Am. Soc. Nephrol. 25, 2573–2583 (2014)

Article  CAS  PubMed  Google Scholar 

Y. Liu, Y. Geng, K. Li, F. Wang, H. Zhou, W. Wang, J. Hou, W. Liu, Comparative proteomic analysis of the function and network mechanisms of MASPIN in human lung cells. Exp. Ther. Med. 3, 470–474 (2012)

Article  CAS  PubMed  Google Scholar 

M.J. Scanlan, Y.T. Chen, B. Williamson, A.O. Gure, E. Stockert, J.D. Gordan, O. Tureci, U. Sahin, M. Pfreundschuh, L.J. Old, Characterization of human colon cancer antigens recognized by autologous antibodies. Int J. Cancer 76, 652–658 (1998)

Article  CAS  PubMed  Google Scholar 

J. Huang, E.H. Ji, X. Zhao, L. Cui, K. Misuno, M. Guo, Z. Huang, X. Chen, S. Hu, Sox11 promotes head and neck cancer progression via the regulation of SDCCAG8. J. Exp. Clin. Cancer Res. 38, 138 (2019)

Article  CAS  PubMed  Google Scholar 

T. Kawano, S. Yanoma, Y. Nakamura, O. Shiono, T. Kokatu, A. Kubota, M. Furukawa, M. Tsukuda, Evaluation of soluble adhesion molecules CD44 (CD44st, CD44v5, CD44v6), ICAM-1, and VCAM-1 as tumor markers in head and neck cancer. Am. J. Otolaryngol. 26, 308–313 (2005)

Article  CAS  PubMed  Google Scholar 

P. Wang, C. Weng, Y. Hou, S. Jian, K. Fang, M. Hou, K. Cheng, Activation of VCAM-1 and Its associated molecule CD44 leads to increased malignant potential of breast cancer cells. Int J. Mol. Sci. 15, 3560–3579 (2014)

Article  CAS  PubMed  Google Scholar 

F. Zhou, J. Chen, G. Tao, M. Zhu, W. Xie, X. Cao, Increased levels of exhaled sICAM1, sVCAM1, and sE-selectin in patients with non-small cell lung cancer. Resp. Med 108, 1670–1676 (2014)

Article  Google Scholar 

Y.B. Ding, G.Y. Chen, J.G. Xia, X.W. Zang, H.Y. Yang, L. Yang, Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma. World J. Gastroenterol. 9, 1409–1414 (2003)

Article  CAS  PubMed  Google Scholar 

Ö. Kemik, A.S. Kemik, I. Hasirci, M. Adaş, S. Purisa, A.C. Dülger, Serum level of soluble vascular adhesion molecule 1 in patients with rectal cancer. Eur. J. Gen. Med. 8, 105–109 (2011)

CAS  Google Scholar 

R.S. Svatek, C. Jeldres, P.I. Karakiewicz, N. Suardi, J. Walz, C.G. Roehrborn, F. Montorsi, K.M. Slawin, S.F. Shariat, Pre-treatment biomarker levels improve the accuracy of post-prostatectomy nomogram for prediction of biochemical recurrence. Prostate 69, 886–894 (2009)

Article  CAS  PubMed  Google Scholar 

V. Dymicka-Piekarska, K. Guzinska-Ustymowicz, A. Kuklinski, H. Kemona, Prognostic significance of adhesion molecules (sICAM-1, sVCAM-1) and VEGF in colorectal cancer patients. Thromb. Res. 129, e47–e50 (2012)

Article  CAS  PubMed  Google Scholar 

A.A. Tempia-Caliera, L.Z. Horvath, A. Zimmermann, T.T. Tihanyi, M. Korc, H. Friess, M.W. Büchler, Adhesion molecules in human pancreatic cancer. J. Surg. Oncol. 79, 93–100 (2002)

Article  CAS  PubMed  Google Scholar 

J.M. Scalici, S. Thomas, C. Harrer, T.A. Raines, J. Curran, K.A. Atkins, M.R. Conaway, L. Duska, K.A. Kelly, J.K. Slack-Davis, Imaging VCAM-1 as an indicator of treatment efficacy in metastatic ovarian cancer. J. Nucl. Med. 54, 1883–1889 (2013)

Article  CAS  PubMed  Google Scholar 

F. Perabo, S. Sharma, R. Gierer, A. Wirger, R. Fimmers, G. Steiner, M. Adam, W. Schultze-Seemann, Circulating intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in urological malignancies. Indian J. Cancer 38, 1–7 (2001)

CAS  PubMed 

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