Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022. https://doi.org/10.1158/2159-8290.CD-21-1059.
Navarro C, Ortega Á, Santeliz R, Garrido B, Chacín M, Galban N, et al. Metabolic reprogramming in cancer cells: emerging molecular mechanisms and novel therapeutic approaches. Pharmaceutics. 2022. https://doi.org/10.3390/pharmaceutics14061303.
Article PubMed PubMed Central Google Scholar
Vettore L, Westbrook RL, Tennant DA. New aspects of amino acid metabolism in cancer. Br J Cancer. 2020. https://doi.org/10.1038/s41416-019-0620-5.
Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, et al. Asparagine bioavailability governs metastasis in a model of breast cancer. Nature. 2018;554:378–81.
Article CAS PubMed PubMed Central Google Scholar
Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, et al. As extracellular glutamine levels decline, asparagine becomes an essential amino acid. Cell Metab. 2018;27:428-438.e5.
Article CAS PubMed PubMed Central Google Scholar
Lefin N, Miranda J, Beltrán JF, Belén LH, Effer B, Pessoa A, et al. Current state of molecular and metabolic strategies for the improvement of L-asparaginase expression in heterologous systems. Front Pharmacol. 2023.
Sun J, Nagel R, Zaal EA, Ugalde AP, Han R, Proost N, et al. SLC 1A3 contributes to L-asparaginase resistance in solid tumors. EMBO J. 2019. https://doi.org/10.15252/embj.2019102147.
Article PubMed PubMed Central Google Scholar
Nakamura A, Nambu T, Ebara S, Hasegawa Y, Toyoshima K, Tsuchiya Y, et al. Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response. Proc Natl Acad Sci USA. 2018. https://doi.org/10.1073/pnas.1805523115.
Article PubMed PubMed Central Google Scholar
Pathria G, Lee JS, Hasnis E, Tandoc K, Scott DA, Verma S, et al. Translational reprogramming marks adaptation to asparagine restriction in cancer. Nat Cell Biol. 2019;21:1590.
Article CAS PubMed PubMed Central Google Scholar
Recouvreux MV, Grenier SF, Zhang Y, Esparza E, Lambies G, Galapate CM, et al. Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma. Nat Cancer. 2023. https://doi.org/10.1038/s43018-023-00649-1.
Article PubMed PubMed Central Google Scholar
Karpel-Massler G, Ramani D, Shu C, Halatsch ME, Westhoff MA, Bruce JN, et al. Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo. Oncotarget. 2016;7:33512.
Article PubMed PubMed Central Google Scholar
Chandel NS. Amino acid metabolism. Cold Spring Harb Perspect Biol. 2021;13:a040584.
Article CAS PubMed PubMed Central Google Scholar
Kandasamy P, Zlobec I, Nydegger DT, Pujol-Giménez J, Bhardwaj R, Shirasawa S, et al. Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. Mol Oncol. 2021;15:2782.
Article CAS PubMed PubMed Central Google Scholar
Taurino G, Chiu M, Bianchi MG, Griffini E, Bussolati O. The SLC38A5 /SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment. Am J Physiol Cell Physiol. 2023;325:C550.
Article CAS PubMed Google Scholar
Magi S, Piccirillo S, Amoroso S, Lariccia V. Excitatory amino acid transporters (Eaats): glutamate transport and beyond. Int J Mol Sci. 2019. https://doi.org/10.3390/ijms20225674.
Article PubMed PubMed Central Google Scholar
Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016. https://doi.org/10.1038/ncomms11457.
Article PubMed PubMed Central Google Scholar
Luo M, Brooks M, Wicha MS. Asparagine and glutamine: co-conspirators fueling metastasis. Cell Metab. 2018;27:947–9. https://doi.org/10.1016/j.cmet.2018.04.012.
Article CAS PubMed Google Scholar
Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, et al. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol Cell. 2014;56:205.
Article CAS PubMed PubMed Central Google Scholar
Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, et al. Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin. Cancer Res. 2007;67:3345.
Article CAS PubMed Google Scholar
Yang H, He X, Zheng Y, Feng W, Xia X, Yu X, et al. Down-regulation of asparagine synthetase induces cell cycle arrest and inhibits cell proliferation of breast cancer. Chem Biol Drug Des. 2014;84:578.
Article CAS PubMed Google Scholar
Xu Y, Lv F, Zhu X, Wu Y, Shen X. Loss of asparagine synthetase suppresses the growth of human lung cancer cells by arresting cell cycle at G0/G1 phase. Cancer Gene Ther. 2016;23:287.
Article CAS PubMed Google Scholar
Yu Q, Wang X, Wang L, Zheng J, Wang J, Wang B. Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells. Scand J Gastroenterol. 2016;51:1220.
Article CAS PubMed Google Scholar
Huang L, Guo Z, Wang F, Fu L. KRAS mutation: from undruggable to druggable in cancer. Signal Transduct Target Ther. 2021. https://doi.org/10.1038/s41392-021-00780-4.
Article PubMed PubMed Central Google Scholar
Kerk SA, Papagiannakopoulos T, Shah YM, Lyssiotis CA. Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment. Nat Rev Cancer. 2021. https://doi.org/10.1038/s41568-021-00375-9.
Article PubMed PubMed Central Google Scholar
Suzuki T, Kishikawa T, Sato T, Takeda N, Sugiura Y, Seimiya T, et al. Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells. Cancer Gene Ther. 2022;29:505.
Article CAS PubMed Google Scholar
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science. 1979;2009:325.
Chidley C, Darnell AM, Gaudio BL, Lien EC, Barbeau AM, Vander Heiden MG, et al. A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments. Nat Cell Biol. 2024;26:825–38. https://doi.org/10.1038/s41556-024-01402-1.
Article CAS PubMed PubMed Central Google Scholar
Toda K, Kawada K, Iwamoto M, Inamoto S, Sasazuki T, Shirasawa S, et al. Metabolic alterations caused by KRAS mutations in colorectal cancer contribute to cell adaptation to glutamine depletion by upregulation of asparagine synthetase. Neoplasia. 2016;18:654.
Article CAS PubMed PubMed Central Google Scholar
Gwinn DM, Lee AG, Briones-Martin-del-Campo M, Conn CS, Simpson DR, Scott AI, et al. Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018;33:91.
Article CAS PubMed PubMed Central Google Scholar
Yang R, Li X, Wu Y, Zhang G, Liu X, Li
留言 (0)