Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33. https://doi.org/10.3322/caac.21708.

Article  PubMed  Google Scholar 

Kim SJ, Khadka D, Seo JH. Interplay between Solid Tumors and Tumor Microenvironment. Front Immunol. 2022;13:882718. https://doi.org/10.3389/fimmu.2022.882718.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao XQ, Xu J, Wang W, Liang C, Hua J, Liu J, et al. Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer. 2021;20:131. https://doi.org/10.1186/s12943-021-01428-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng C, Zhuge LD, Xiao X, Luan SY, Yuan Y. Overcoming resistance to PD-1/PD-L1 inhibitors in esophageal cancer. Front Oncol. 2022;12:955163. https://doi.org/10.3389/fonc.2022.955163.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Q, Chen Y, Li XJ, Long SQ, Shi Y, Yu YY, et al. The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers. Front Immunol. 2022;13:964442. https://doi.org/10.3389/fimmu.2022.964442.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yi M, Zheng XL, Niu M, Zhu SL, Ge H, Wu KM. Combination strategies with PD-1/PD-L1 blockade: current advances and future directions. Mol Cancer. 2022;21:28. https://doi.org/10.1186/s12943-021-01489-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen DW, Barsoumian HB, Yang LP, Younes AI, Verma V, Hu Y, et al. SHP-2 and PD-L1 inhibition combined with radiotherapy enhances systemic antitumor effects in an anti-PD-1-resistant model of non-small-cell lung cancer. Cancer Immunol Res. 2020;8:883–94. https://doi.org/10.1158/2326-6066.CIR-19-0744.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horvath L, Thienpont B, Zhao LY, Wolf D, Pircher A. Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook. Mol Cancer. 2020;19:141. https://doi.org/10.1186/s12943-020-01260-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Genova C, Dellepiane C, Carrega P, Sommariva S, Ferlazzo G, Pronzato P, et al. Therapeutic Implications of Tumor Microenvironment in Lung Cancer: Focus on Immune Checkpoint Blockade. Front Immunol. 2022;12:799455. https://doi.org/10.3389/fimmu.2021.799455.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tiwari A, Trivedi R, Lin SY. Tumor microenvironment: barrier or opportunity towards effective cancer therapy. J Biomed Sci. 2022;29:83. https://doi.org/10.1186/s12929-022-00866-3.

Article  PubMed  PubMed Central  Google Scholar 

Chen YM, Jiang ZL, Yang Y, Zhang CX, Liu HY, Wan JH. The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives. Int J Biol Macromol. 2023;253:126773. https://doi.org/10.1016/j.ijbiomac.2023.126773.

Article  CAS  PubMed  Google Scholar 

Pu X, Wu YT, Ji Q, Fu SQ, Zuo H, Chu LM, et al. Mechanisms of N6-methyladenosine modification in tumor development and potential therapeutic strategies (Review). Int J Oncol. 2023;62:75. https://doi.org/10.3892/ijo.2023.5523.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu JX, Xue C, Wang QQ. N6-methyladenosine modification: an important player in the tumor immune microenvironment. Biomed Pharmacother. 2023;165:115171. https://doi.org/10.1016/j.biopha.2023.115171.

Article  CAS  PubMed  Google Scholar 

Xu P, Hu K, Zhang P, Sun ZG, Zhang N. Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis. Cancer Cell Int. 2022;22:13. https://doi.org/10.1186/s12935-021-02368-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Kang YQ, Wang LL, Huff S, Tang R, Hui H, et al. ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment. Proc Natl Acad Sci U S A. 2020;117:20159–70. https://doi.org/10.1073/pnas.1918986117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong F, Qin XY, Wang BF, Li Q, Hu JY, Cheng X, et al. ALKBH5 facilitates hypoxia-induced paraspeckle assembly and IL8 secretion to generate an immunosuppressive tumor microenvironment. Cancer Res. 2021;81:5876–88. https://doi.org/10.1158/0008-5472.CAN-21-1456.

Article  CAS  PubMed  Google Scholar 

Cao XX, Geng QS, Fan DP, Wang Q, Wang X, Zhang MX, et al. m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion. Mol Cancer. 2023;22:42. https://doi.org/10.1186/s12943-022-01704-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu JX, Wei LY, Hu N, Wang D, Ni J, Zhang S, et al. FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer. J Immunother Cancer. 2022;10:e005116. https://doi.org/10.1136/jitc-2022-005116.

Article  PubMed  PubMed Central  Google Scholar 

Zhou L, Xu QL, Huang LT, Jin JJ, Zuo XY, Zhang Q, et al. Low-dose carboplatin reprograms tumor immune microenvironment through STING signaling pathway and synergizes with PD-1 inhibitors in lung cancer. Cancer Lett. 2021;500:163–71. https://doi.org/10.1016/j.canlet.2020.11.049.

Article  CAS  PubMed  Google Scholar 

Hu YY, Gong CL, Li ZB, Liu J, Chen Y, Huang Y, et al. Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol Cancer. 2022;21:34. https://doi.org/10.1186/s12943-022-01522-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui YB, Zhang CY, Ma SS, Li Z, Wang WJ, Li Y, et al. RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma. J Exp Clin Cancer Res. 2021;40:294. https://doi.org/10.1186/s13046-021-02096-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu RS, Liu WW, Yang QP, Zhang JL, Hou P, Xiong JH, et al. LncTUG1 promotes hepatocellular carcinoma immune evasion via upregulating PD-L1 expression. Sci Rep. 2023;13:16998. https://doi.org/10.1038/s41598-023-42948-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang PP, Tao LQ, Yu YD, Wang Q, Ye PH, Sun Y, et al. Oral squamous cell carcinoma cell-derived GM-CSF regulates PD-L1 expression in tumor-associated macrophages through the JAK2/STAT3 signaling pathway. Am J Cancer Res. 2023;13:589–601.

PubMed  PubMed Central  Google Scholar 

Liu W, Wang XD, Wang L, Mei Y, Yun YN, Yao XB, et al. Oridonin represses epithelial-mesenchymal transition and angiogenesis of thyroid cancer via downregulating JAK2/STAT3 signaling. Int J Med Sci. 2022;19:965–74. https://doi.org/10.7150/ijms.70733.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu MS, Wang Y, Xia RL, Wei YQ, Wei XW. Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting. Cell Prolif. 2021;54:e13115. https://doi.org/10.1111/cpr.13115.

Article  CAS  PubMed  PubMed Central