Phi LTH, Sari IN, Yang YG, Lee SH, Jun N, Kim KS, Lee YK, Kwon HY (2018) Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment. Stem Cells Int. https://doi.org/10.1155/2018/5416923
Article PubMed PubMed Central Google Scholar
Sampieri K, Fodde R (2012) Cancer stem cells and metastasis. Semin Cancer Biol 22(3):187–193. https://doi.org/10.1016/j.semcancer.2012.03.002
Article CAS PubMed Google Scholar
Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G (2014) Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 345(6203):1509–1512. https://doi.org/10.1126/science.1256337
Article CAS PubMed PubMed Central Google Scholar
Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G (2020) Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study. Lancet Haematol 7(2):e134–e145. https://doi.org/10.1016/s2352-3026(19)30202-9
Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G (2017) EPCR expression marks UM171-expanded CD34(+) cord blood stem cells. Blood 129(25):3344–3351. https://doi.org/10.1182/blood-2016-11-750729
Article CAS PubMed Google Scholar
Subramaniam A, Žemaitis K, Talkhoncheh MS, Yudovich D, Bäckström A, Debnath S, Chen J, Jain MV, Galeev R, Gaetani M, Zubarev RA, Larsson J (2020) Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171. Blood 136(19):2151–2161. https://doi.org/10.1182/blood.2020005827
Article CAS PubMed PubMed Central Google Scholar
Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau G (2021) UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3-KBTBD4 complex. Cell Stem Cell 28(1):48–62. https://doi.org/10.1016/j.stem.2020.12.002
Article CAS PubMed Google Scholar
Hu A, Gao J, Varier KM, Gajendran B, Jiang F, Liu W, Wang C, Xiao X, Li Y, Zacksenhaus E, Ali S, Ben-David Y (2022) UM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression. Cell Death Discov 8(1):448. https://doi.org/10.1038/s41420-022-01244-6
Article CAS PubMed PubMed Central Google Scholar
Wang JC, Dick JE (2005) Cancer stem cells: lessons from leukemia. Trends Cell Biol 15(9):494–501. https://doi.org/10.1016/j.tcb.2005.07.004
Article CAS PubMed Google Scholar
Agboyibor C, Dong J, Effah CY, Drokow EK, Pervaiz W, Liu HM (2021) LSD1 as a biomarker and the outcome of its inhibitors in the clinical trial: the therapy opportunity in tumor. J Oncol. https://doi.org/10.1155/2021/5512524
Article PubMed PubMed Central Google Scholar
Ravasio R, Ceccacci E, Nicosia L, Hosseini A, Rossi PL, Barozzi I, Fornasari L, Zuffo RD, Valente S, Fioravanti R, Mercurio C, Varasi M, Mattevi A, Mai A, Pavesi G, Bonaldi T, Minucci S (2020) Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation. Sci Adv 6(15):2746. https://doi.org/10.1126/sciadv.aax2746
Wu N, Chen S, Luo Q, Jiang Z, Wang X, Li Y, Qiu J, Yu K, Yang Y, Zhuang J (2022) Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma. Exp Eye Res 216:108955. https://doi.org/10.1016/j.exer.2022.108955
Article CAS PubMed Google Scholar
Li J, Jiang JL, Chen YM, Lu WQ (2023) KLF2 inhibits colorectal cancer progression and metastasis by inducing ferroptosis via the PI3K/AKT signaling pathway. J Pathol Clin Res 9(5):423–435. https://doi.org/10.1002/cjp2.325
Article CAS PubMed PubMed Central Google Scholar
Li XM, Hu SJ, Liu JF, Ma MJ, Du LM, Bai FH (2023) Krüppel-like factor 2 is a gastric cancer suppressor and prognostic biomarker. Evid-Based Complement Altern Med: eCAM. https://doi.org/10.1155/2023/2360149
Liu CY, Chang TH, Hsieh CH, Chang YH, Pang JS, Chuang CK (2022) Kruppel-like factor 2 inhibits proliferation in renal angiomyolipoma via IL-6/JAK/STAT3 signaling pathway. Anticancer Res 42(10):4753–4762. https://doi.org/10.2187/anticanres.15980
Article CAS PubMed Google Scholar
Gao J, Hu J, Yu F, Wang C, Sheng D, Liu W, Hu A, Yu K, Xiao X, Kuang Y, Zacksenhaus E, Gajendran B, Ben-David Y (2023) Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling. BMC Cancer 23(1):306. https://doi.org/10.1186/s12885-023-10742-4
Article CAS PubMed PubMed Central Google Scholar
Zhu KY, Tian Y, Li YX, Meng QX, Ge J, Cao XC, Zhang T, Yu Y (2022) The functions and prognostic value of Krüppel-like factors in breast cancer. Cancer Cell Int 22(1):23. https://doi.org/10.1186/s12935-022-02449-6
Article CAS PubMed PubMed Central Google Scholar
Wang C, Sample KM, Gajendran B, Kapranov P, Liu W, Hu A, Zacksenhaus E, Li Y, Hao X, Ben-David Y (2021) FLI1 induces megakaryopoiesis gene expression through WAS/WIP-dependent and independent mechanisms; implications for wiskott-aldrich syndrome. Front Immunol 12:607836. https://doi.org/10.3389/fimmu.2021.607836
Article CAS PubMed PubMed Central Google Scholar
Crown J, O’Leary M, Ooi WS (2004) Docetaxel and paclitaxel in the treatment of breast cancer: a review of clinical experience. Oncologist 9(2):24–32. https://doi.org/10.1634/theoncologist.9-suppl_2-24
Article CAS PubMed Google Scholar
Kunder R, Velyunskiy M, Dunne SF, Cho BK, Kanojia D, Begg L, Orriols AM, Fleming-Trujillo E, Vadlamani P, Vialichka A, Bolin R, Perrino JN, Roth D, Clutter MR, Zielinski-Mozny NA, Goo YA, Cristofanilli M, Mendillo ML, Vassilopoulos A, Horiuchi D (2022) Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer. Cell Chem Biol 29(3):358–372. https://doi.org/10.1016/j.chembiol.2021.08.011
Article CAS PubMed Google Scholar
Landor SKJ, Santio NM, Eccleshall WB, Paramonov VM, Gagliani EK, Hall D, Jin SB, Dahlström KM, Salminen TA, Rivero-Müller A, Lendahl U, Kovall RA, Koskinen PJ, Sahlgren C (2021) PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. J Biol Chem 296:100593. https://doi.org/10.1016/j.jbc.2021.100593
Article CAS PubMed PubMed Central Google Scholar
Zhao W, Qiu R, Li P, Yang J (2017) PIM1: a promising target in patients with triple-negative breast cancer. Med Oncol 34(8):142. https://doi.org/10.1007/s12032-017-0998-y
Article CAS PubMed Google Scholar
Sawaguchi Y, Yamazaki R, Nishiyama Y, Mae M, Abe A, Nishiyama H, Nishisaka F, Ibuki T, Sasai T, Matsuzaki T (2021) Novel pan-pim kinase inhibitors with imidazopyridazine and thiazolidinedione structure exert potent antitumor activities. Front Pharmacol 12:672536. https://doi.org/10.3389/fphar.2021.672536
Article CAS PubMed PubMed Central Google Scholar
Rajan AM, Kumar S (2016) New investigational drugs with single-agent activity in multiple myeloma. Blood Cancer J 6(7):e451. https://doi.org/10.1038/bcj.2016.53
Article CAS PubMed PubMed Central Google Scholar
Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MC, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN (2016) PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat Med 22(11):1303–1313. https://doi.org/10.1038/nm.4198
留言 (0)