Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, et al. Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. J Biol Chem. 2000;275:36457–64.

Article  CAS  PubMed  Google Scholar 

Uemura A, Fukushima Y. Rho GTPases in Retinal Vascular Diseases. Int J Mol Sci. 2021;22:3684.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol. 2008;9:690–701.

Article  CAS  PubMed  Google Scholar 

Mosaddeghzadeh N, Ahmadian MR. The RHO family GTPases: mechanisms of regulation and signaling. Cells. 2021;10:1831.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cervantes-Villagrana RD, Color-Aparicio VM, Reyes-Cruz G, Vazquez-Prado J. Protumoral bone marrow-derived cells migrate via Gbetagamma-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal. 2019;13:179–91.

Article  PubMed  PubMed Central  Google Scholar 

Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, et al. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood. 2012;120:914–23.

Article  CAS  PubMed  Google Scholar 

Eelen G, Dubois C, Cantelmo AR, Goveia J, Bruning U, DeRan M, et al. Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Nature. 2018;561:63–69.

Article  CAS  PubMed  Google Scholar 

Valdembri D, Serini G. Angiogenesis: the Importance of RHOJ-mediated trafficking of active integrins. Curr Biol. 2020;30:R652–4.

Article  CAS  PubMed  Google Scholar 

Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park JS, et al. Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. 2014;25:102–17.

Article  CAS  PubMed  Google Scholar 

Wang M, Zhang C, Zheng Q, Ma Z, Qi M, Di G, et al. RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways. Int J Biol Sci. 2022;18:942–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruiz R, Jahid S, Harris M, Marzese DM, Espitia F, Vasudeva P, et al. The RhoJ-BAD signaling network: An Achilles’ heel for BRAF mutant melanomas. PLoS Genet. 2017;13:e1006913.

Article  PubMed  PubMed Central  Google Scholar 

Wang M, Jiang X, Yang Y, Chen H, Zhang C, Xu H, et al. Rhoj Is a novel target for progression and invasion of glioblastoma by impairing cytoskeleton dynamics. Neurotherapeutics. 2020;17:2028–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, Yuan Y, Sun L, Chen J, Yang M, Yin Y, et al. MKL1 mediates TGF-beta induced RhoJ transcription to promote breast cancer cell migration and invasion. Front Cell Dev Biol. 2020;8:832.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Debaugnies M, Rodriguez-Acebes S, Blondeau J, Parent MA, Zocco M, Song Y, et al. RHOJ controls EMT-associated resistance to chemotherapy. Nature. 2023;616:168–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, et al. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022;39:110641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J Cell Sci. 2005;118:843–6.

Article  CAS  PubMed  Google Scholar 

Letunic I, Bork P. Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Nucleic Acids Res. 2021;49:W293–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ackermann KL, Florke RR, Reyes SS, Tader BR, Hamann MJ. TCL/RhoJ plasma membrane localization and nucleotide exchange is coordinately regulated by amino acids within the N terminus and a distal loop region. J Biol Chem. 2016;291:23604–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Florke RR, Young GT, Hamann MJ. Unraveling a model of TCL/RhoJ allosterism using TC10 reverse chimeras. Small GTPases. 2020;11:138–45.

Article  PubMed  Google Scholar 

Qadir MI, Parveen A, Ali M. Cdc42: role in cancer management. Chem Biol Drug Des. 2015;86:432–9.

Article  CAS  PubMed  Google Scholar 

Murphy GA, Solski PA, Jillian SA, Perez de la Ossa P, D’Eustachio P, Der CJ, et al. Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth. Oncogene. 1999;18:3831–45.

Article  CAS  PubMed  Google Scholar 

Tong S, Liss AS, You M, Bose HR Jr. The activation of TC10, a Rho small GTPase, contributes to v-Rel-mediated transformation. Oncogene. 2007;26:2318–29.

Article  CAS  PubMed  Google Scholar 

Satoh K, Sakai S, Nishizuka M. Knockdown of RhoQ, a member of Rho GTPase, accelerates TGF-beta-induced EMT in human lung adenocarcinoma. Biochem Biophys Rep. 2022;32:101346.

CAS  PubMed  PubMed Central  Google Scholar 

Bridges E, Sheldon H, Kleibeuker E, Ramberger E, Zois C, Barnard A, et al. RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain. Angiogenesis. 2020;23:493–513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farhan H, Hsu VW. Cdc42 and cellular polarity: emerging roles at the golgi. Trends Cell Biol. 2016;26:241–8.

Article  CAS  PubMed  Google Scholar 

Cerione RA. Cdc42: new roads to travel. Trends Cell Biol. 2004;14:127–32.

Article  CAS  PubMed  Google Scholar 

Sundararaman A, Fukushima Y, Norman JC, Uemura A, Mellor H. RhoJ regulates alpha5beta1 integrin trafficking to control fibronectin remodeling during angiogenesis. Curr Biol. 2020;30:2146–55.e5.

Article  CAS  PubMed  Google Scholar 

Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, et al. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. J Clin Invest. 2011;121:1974–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kusuhara S, Fukushima Y, Fukuhara S, Jakt LM, Okada M, Shimizu Y, et al. Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. PLoS ONE. 2012;7:e45858.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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