Balachandran VP, Beatty GL, Dougan SK. Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities. Gastroenterology. 2019;156:2056–72.
Article CAS PubMed Google Scholar
Wang D, Liu C, Zhou Y, et al. Effect of neoadjuvant radiotherapy on survival of non-metastatic pancreatic ductal adenocarcinoma: a SEER database analysis. Radiat Oncol. 2020;15:107.
Article CAS PubMed PubMed Central Google Scholar
Riquelme E, Zhang Y, Zhang L, et al. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell. 2019;178:795-806.e12.
Article CAS PubMed PubMed Central Google Scholar
Chandana S, Babiker HM, Mahadevan D. Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC). Expert Opin Investig Drugs. 2019;28:161–77.
Article CAS PubMed Google Scholar
Singhi AD, Koay EJ, Chari ST, et al. Early detection of pancreatic cancer: opportunities and challenges. Gastroenterology. 2019;156:2024–40.
Tomaino B, Cappello P, Capello M, et al. Autoantibody signature in human ductal pancreatic adenocarcinoma. J Proteome Res. 2007;6:4025–31.
Article CAS PubMed Google Scholar
Cappello P, Tomaino B, Chiarle R, et al. An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen. Int J Cancer. 2009;125:639–48.
Article CAS PubMed Google Scholar
Capello M, Ferri-Borgogno S, Cappello P, et al. α-Enolase: a promising therapeutic and diagnostic tumor target. FEBS J. 2011;278:1064–74.
Article CAS PubMed Google Scholar
Principe M, Borgoni S, Cascione M, et al. Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis. J Hematol Oncol. 2017;10:16.
Article PubMed PubMed Central Google Scholar
Principe M, Ceruti P, Shih NY, et al. Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells. Oncotarget. 2015;6:11098–113.
Article PubMed PubMed Central Google Scholar
Cappello P, Rolla S, Chiarle R, et al. Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer. Gastroenterology. 2013;144:1098–106.
Article CAS PubMed Google Scholar
Cappello P, Curcio C, Mandili G, et al. Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners. Cancers (Basel). 2018;10:51.
Hirsch E, Novelli F. Cancer: natural-born killers unleashed. Nature. 2014;510:342–3.
Article CAS PubMed Google Scholar
Kaneda MM, Cappello P, Nguyen AV, et al. Macrophage PI3Kγ drives pancreatic ductal adenocarcinoma progression. Cancer Discov. 2016;6:870–85.
Article CAS PubMed PubMed Central Google Scholar
Gabriel ANA, Jiao Q, Yvette U, et al. Differences between KC and KPC pancreatic ductal adenocarcinoma mice models, in terms of their modeling biology and their clinical relevance. Pancreatology. 2020;20:79–88.
Loi M, Di Paolo D, Becherini P, et al. The use of the orthotopic model to validate antivascular therapies for cancer. Int J Dev Biol. 2011;55:547–55.
Article CAS PubMed Google Scholar
Li G, Zhao L. Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment. Drug Deliv. 2019;26:756–64.
Article CAS PubMed PubMed Central Google Scholar
Consolino L, Longo DL, Dastrù W, et al. Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging. Int J Cancer. 2016;139:404–13.
Article CAS PubMed Google Scholar
Zampini MA, Buizza G, Paganelli C, et al. Perfusion and diffusion in meningioma tumors: a preliminary multiparametric analysis with dynamic susceptibility contrast and intravoxel incoherent motion MRI. Magn Reson Imaging. 2020;67:69–78.
Donofrio G, Tebaldi G, Lanzardo S, et al. Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells. Oncoimmunology. 2018;7: e1494108.
Article PubMed PubMed Central Google Scholar
Giovarelli M, Cappello P, Forni G, et al. Tumor rejection and immune memory elicited by locally released LEC chemokine are associated with an impressive recruitment of APCs, lymphocytes, and granulocytes. J Immunol. 2000;164:3200–6.
Article CAS PubMed Google Scholar
Lambert SL, Okada CY, Levy R. TCR vaccines against a murine T cell lymphoma: a primary role for antibodies of the IgG2c class in tumor protection. J Immunol. 2004;172:929–36.
Article CAS PubMed Google Scholar
Corbière V, Chapiro J, Stroobant V, et al. Antigen spreading contributes to MAGE vaccination-induced regression of melanoma metastases. Cancer Res. 2011;71:1253–62.
Crotty S. T follicular helper cell differentiation, function, and roles in disease. Immunity. 2014;41:529–42.
Article CAS PubMed PubMed Central Google Scholar
Falcomatà C, Bärthel S, Widholz SA, et al. Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. 2022;3:318–36.
Article PubMed PubMed Central Google Scholar
Johnson BA, Yarchoan M, Lee V, et al. Strategies for increasing pancreatic tumor immunogenicity. Clin Cancer Res. 2017;23:1656–69.
Article PubMed PubMed Central Google Scholar
Popovic A, Jaffee EM, Zaidi N. Emerging strategies for combination checkpoint modulators in cancer immunotherapy. J Clin Invest. 2018;128:3209–18.
Article PubMed PubMed Central Google Scholar
Mandili G, Curcio C, Bulfamante S, et al. In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination. J Immunother Cancer. 2020;8: e001071.
Article PubMed PubMed Central Google Scholar
Ali K, Soond DR, Pineiro R, et al. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014;510:407–11.
Article CAS PubMed PubMed Central Google Scholar
Shimabukuro-Vornhagen A, Schlößer HA, Gryschok L, et al. Characterization of tumor-associated B-cell subsets in patients with colorectal cancer. Oncotarget. 2014;5:4651–64.
Article PubMed PubMed Central Google Scholar
Shalapour S, Font-Burgada J, Di Caro G, et al. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015;521:94–8.
Article CAS PubMed PubMed Central Google Scholar
Bruno T. New predictors for immunotherapy responses sharpen our view of the tumour microenvironment. Nature. 2020;577:474–6.
Article CAS PubMed PubMed Central Google Scholar
Sautes̀-Fridman C, Petitprez F, Calderaro J, et al. Tertiary lymphoid structures in the era of cancer immunotherapy. Nat Rev Cancer. 2019;19:307–25.
Joshi NS, Akama-Garren EH, Lu Y, et al. Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-Tumor T Cell Responses. Immunity. 2015;43:579–90.
Article CAS PubMed PubMed Central Google Scholar
Zhu G, Nemoto S, Mailloux AW, et al. Induction of tertiary lymphoid structures with antitumor function by a lymph node-derived stromal cell line. Front Immunol. 2018;9:1609.
Article PubMed PubMed Central Google Scholar
Castino GF, Cortese N, Capretti G, et al. Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma. Oncoimmunology. 2015;5: e1085147.
Article PubMed PubMed Central Google Scholar
Li K, Tandurella JA, Gai J, et al. Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy. Cancer Cell. 2022;40:1374–91.
留言 (0)