Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice

Abdelnabi M, Leelaviwat N, Liao ED, Motamedi S, Pangkanon W, Nugent K (2023) Daptomycin-induced rhabdomyolysis complicated with acute gouty arthritis. Am J Med Sci 365:450–456. https://doi.org/10.1016/j.amjms.2023.01.005

Article  PubMed  Google Scholar 

Borgonetti V, Galeotti N (2023) Honokiol-rich Magnolia officinalis bark extract attenuates trauma-induced neuropathic pain. Antioxidants (basel) 12:1518. https://doi.org/10.3390/antiox12081518

Article  CAS  PubMed  Google Scholar 

Chan SS, Zhao M, Lao L, Fong HH, Che CT (2008) Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum. Planta Med 74:381–384. https://doi.org/10.1055/s-2008-1034320

Article  CAS  PubMed  Google Scholar 

Chaves G, Ayuyan AG, Cherny VV, Morgan D, Franzen A, Fieber L, Nausch L, Derst C, Mahorivska I, Jardin C, DeCoursey TE, Musset B (2023) Unexpected expansion of the voltage-gated proton channel family. FEBS J 290:1008–1026. https://doi.org/10.1111/febs.16617

Article  CAS  PubMed  Google Scholar 

Cheng JJ, Ma XD, Ai GX, Yu QX, Chen XY, Yan F, Li YC, Xie JH, Su ZR, Xie QF (2022) Palmatine protects against MSU-induced gouty arthritis via regulating the NF-κB/NLRP3 and Nrf2 pathways. Drug Des Devel Ther 16:2119–2132. https://doi.org/10.2147/dddt.S356307

Article  PubMed  PubMed Central  Google Scholar 

Cherny VV, Murphy R, Sokolov V, Levis RA, DeCoursey TE (2003) Properties of single voltage-gated proton channels in human eosinophils estimated by noise analysis and by direct measurement. J Gen Physiol 121:615–628. https://doi.org/10.1085/jgp.200308813

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiu KC, Shih YH, Wang TH, Lan WC, Li PJ, Jhuang HS, Hsia SM, Shen YW, Yuan-Chien Chen M, Shieh TM (2021) In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages. J Formos Med Assoc 120:827–837. https://doi.org/10.1016/j.jfma.2020.09.002

Article  CAS  PubMed  Google Scholar 

De La Rosa V, Ramsey IS (2018) Gating currents in the Hv1 proton channel. Biophys J 114:2844–2854. https://doi.org/10.1016/j.bpj.2018.04.049

Article  CAS  PubMed  Google Scholar 

De La Rosa V, Bennett AL, Ramsey IS (2018) Coupling between an electrostatic network and the Zn2+ binding site modulates Hv1 activation. J Gen Physiol 150:863–881. https://doi.org/10.1085/jgp.201711822

Article  CAS  PubMed  Google Scholar 

DeCoursey TE (1991) Hydrogen ion currents in rat alveolar epithelial cells. Biophys J 60:1243–1253. https://doi.org/10.1016/s0006-3495(91)82158-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Decoursey TE (2012) Voltage-gated proton channels. Compr Physiol 2:1355–1385. https://doi.org/10.1002/cphy.c100071

Article  PubMed  PubMed Central  Google Scholar 

Deval E, Noël J, Lay N, Alloui A, Diochot S, Friend V, Jodar M, Lazdunski M, Lingueglia E (2008) ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J 27:3047–3055. https://doi.org/10.1038/emboj.2008.213

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eder C, DeCoursey TE (2001) Voltage-gated proton channels in microglia. Prog Neurobiol 64:277–305. https://doi.org/10.1016/s0301-0082(00)00062-9

Article  CAS  PubMed  Google Scholar 

Furutani K, Ji RR (2022) Targeting Hv1 proton channel for pain control. Cell Res 32:419–420. https://doi.org/10.1038/s41422-022-00648-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamedani Y, Chakraborty S, Sabarwal A, Pal S, Bhowmick S, Balan M (2020) Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells. PLoS ONE 15:e0243837. https://doi.org/10.1371/journal.pone.0243837

Article  CAS  PubMed  PubMed Central  Google Scholar 

He J, Ritzel RM, Wu J (2021) Functions and mechanisms of the voltage-gated proton channel Hv1 in brain and spinal cord injury. Front Cell Neurosci 15:662971. https://doi.org/10.3389/fncel.2021.662971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henderson LM, Meech RW (1999) Evidence that the product of the human X-linked CGD gene, gp91-phox, is a voltage-gated H+ pathway. J Gen Physiol 114:771–786. https://doi.org/10.1085/jgp.114.6.771

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez-Espinosa DR, Gale JR, Scrabis MG, Aizenman E (2023) Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity. J Neurochem 165:29–54. https://doi.org/10.1111/jnc.15760

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong L, Kim IH, Tombola F (2014) Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives. Proc Natl Acad Sci USA 111:9971–9976. https://doi.org/10.1073/pnas.1324012111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong J, Qiu J, Wang X, Zhang G (2020) Characteristics of voltage-gated potassium currents in monosodium urate induced gouty arthritis in mice. Inflamm Res 69:589–598. https://doi.org/10.1007/s00011-020-01343-z

Article  CAS  PubMed  Google Scholar 

Keller SF, Mandell BF (2021) Management and cure of gouty arthritis. Med Clin N Am 105:297–310. https://doi.org/10.1016/j.mcna.2020.09.013

Article  PubMed  Google Scholar 

Khalid S, Ullah MZ, Khan AU, Afridi R, Rasheed H, Khan A, Ali H, Kim YS, Khan S (2018) Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-κB and Nrf2 signaling. Front Pharmacol 9:140. https://doi.org/10.3389/fphar.2018.00140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KR, Park KK, Chun KS, Chung WY (2010) Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage. J Pharmacol Sci 114:69–78. https://doi.org/10.1254/jphs.10070fp

Article  CAS  PubMed  Google Scholar 

Korpos É, Papp F (2023) New “kids” on the voltage-gated proton channel block. FEBS J 290:970–973. https://doi.org/10.1111/febs.16670

Article  CAS  PubMed  Google Scholar 

Li S, Li L, Yan H, Jiang X, Hu W, Han N, Wang D (2019) Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models. Mol Med Rep 20:4623–4633. https://doi.org/10.3892/mmr.2019.10708

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Yu Z, Zong W, Chen P, Li J, Wang M, Ding F, Xie M, Wang W, Luo X (2020) Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury. J Neuroinflammation 17:263. https://doi.org/10.1186/s12974-020-01942-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Chen C, Zhang C, Luo R, Lan X, Guo F, Ma L, Fu P, Wang Y (2021) A honokiol-mediated robust coating for blood-contacting devices with anti-inflammatory, antibacterial and antithrombotic properties. J Mater Chem B 9:9770–9783. https://doi.org/10.1039/d1tb01617b

Article  CAS  PubMed  Google Scholar 

Lin YR, Chen HH, Lin YC, Ko CH, Chan MH (2009) Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain. J Biomed Sci 16:94. https://doi.org/10.1186/1423-0127-16-94

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahaut-Smith MP (1989) Separation of hydrogen ion currents in intact molluscan neurones. J Exp Biol 145:439–454. https://doi.org/10.1242/jeb.145.1.439

Article  CAS  PubMed  Google Scholar 

Mao RW, He SP, Lan JG, Zhu WZ (2022) Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission. Br J Pharmacol 179:3886–3904. https://doi.org/10.1111/bph.15837

Article  CAS  PubMed  Google Scholar 

Morgan D, Capasso M, Musset B, Cherny VV, Ríos E, Dyer MJ, DeCoursey TE (2009) Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci USA 106:18022–18027. https://doi.org/10.1073/pnas.0905565106

Article  PubMed  PubMed Central  Google Scholar 

Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE (2008) Detailed comparison of expressed and native voltage-gated proton channel currents. J Physiol 586:2477–2486. https://doi.org/10.1113/jphysiol.2007.149427

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif