Short NJ, Rytting ME, Cortes JE. Acute myeloid leukaemia. Lancet. 2018;392(10147):593–606.

Article  PubMed  PubMed Central  Google Scholar 

Döhner H, Weisdorf DJ, Bloomfield CD. Acute Myeloid Leukemia. N Engl J Med. 2015;373(12):1136–52.

Article  PubMed  Google Scholar 

Chen X, Xie H, Wood BL, et al. Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia. J Clin Oncol. 2015;33(11):1258–64.

Article  PubMed  Google Scholar 

Soares F, Chen B, Lee JB, et al. CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy. Blood. 2021;137(16):2171–81.

Article  CAS  PubMed  Google Scholar 

Ramdzan ZM, Nepveu A. CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers. Nat Rev Cancer. 2014;14(10):673–82.

Article  CAS  PubMed  Google Scholar 

Kaur S, Ramdzan ZM, Guiot MC, et al. CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide. Neuro Oncol. 2018;20(4):484–93.

Article  CAS  PubMed  Google Scholar 

Burton LJ, Hawsawi O, Sweeney J, et al. CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE). PLoS ONE. 2019;14(4):e0214844.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sansregret L, Vadnais C, Livingstone J, et al. Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure. Proc Natl Acad Sci USA. 2011;108(5):1949–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coqueret O, Bérubé G, Nepveu A. The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase. Embo J. 1998;17(16):4680–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santaguida M, Ding Q, Bérubé G, et al. Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2). J Biol Chem. 2001;276(49):45780–90.

Article  CAS  PubMed  Google Scholar 

Sansregret L, Gallo D, Santaguida M, et al. Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle. J Biol Chem. 2010;285(43):32834–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ellis T, Gambardella L, Horcher M, et al. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Genes Dev. 2001;15(17):2307–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

An N, Khan S, Imgruet MK, et al. Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS. Blood. 2018;131(24):2682–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Supper E, Rudat S, Iyer V, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12(1):2482.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu M, Sui L, Fang Z, et al. Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer. Front Oncol. 2023;13:1166955.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo K. Signaling cross talk between TGF-β/Smad and other signaling pathways. Cold Spring Harb Perspect Biol. 2017;9(1): a022137.

Article  PubMed  PubMed Central  Google Scholar 

Huang F, Cao Y, Wu G, et al. BMP2 signalling activation enhances bone metastases of non-small cell lung cancer. J Cell Mol Med. 2020;24(18):10768–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fukuda T, Fukuda R, Miyazono K, et al. Tumor promoting effect of BMP signaling in endometrial cancer. Int J Mol Sci. 2021;22(15):7882.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee JH, Lee GT, Woo SH, et al. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res. 2013;73(12):3604–14.

Article  CAS  PubMed  Google Scholar 

Wong CC, Martincorena I, Rust AG, et al. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet. 2014;46(1):33–8.

Article  CAS  PubMed  Google Scholar 

Topka S, Glassmann A, Weisheit G, et al. The transcription factor Cux1 in cerebellar granule cell development and medulloblastoma pathogenesis. Cerebellum. 2014;13(6):698–712.

Article  CAS  PubMed  Google Scholar 

Ramdzan ZM, Vadnais C, Pal R, et al. RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol. 2014;12(3):e1001807.

Article  PubMed  PubMed Central  Google Scholar 

Adzhubei IA, Schmidt S, Peshkin L, et al. A method and server for predicting damaging missense mutations. Nat Methods. 2010;7(4):248–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian W, Wang Z, Li X, et al. Identification of vital modules and genes associated with heart failure based on weighted gene coexpression network analysis. ESC Heart Fail. 2022;9(2):1370–9.

Article  PubMed  PubMed Central  Google Scholar 

Griesmann H, Mühl S, Riedel J, et al. CUX1 enhances pancreatic cancer formation by synergizing with KRAS and inducing MEK/ERK-dependent proliferation. Cancers (Basel). 2021;13(10):2462.

Article  CAS  PubMed  Google Scholar 

Tallman MS, Wang ES, Altman JK, et al. Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019;17(6):721–49.

Article  CAS  PubMed  Google Scholar 

Saygin C, Carraway HE. Emerging therapies for acute myeloid leukemia. J Hematol Oncol. 2017;10(1):93.

Article  PubMed  PubMed Central  Google Scholar 

Short NJ, Konopleva M, Kadia TM, et al. Advances in the treatment of acute myeloid leukemia: new drugs and new challenges. Cancer Discov. 2020;10(4):506–25.

Article  CAS  PubMed  Google Scholar 

Döhner H, Wei AH, Löwenberg B. Towards precision medicine for AML. Nat Rev Clin Oncol. 2021;18(9):577–90.

Article  PubMed  Google Scholar 

Kadia TM, Ravandi F, Cortes J, et al. New drugs in acute myeloid leukemia. Ann Oncol. 2016;27(5):770–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H. Emerging agents and regimens for AML. J Hematol Oncol. 2021;14(1):49.

Article  PubMed  PubMed Central  Google Scholar 

Yang X, Wang J. Precision therapy for acute myeloid leukemia. J Hematol Oncol. 2018;11(1):3.

Article  PubMed  PubMed Central  Google Scholar 

Carter JL, Hege K, Yang J, et al. Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy. Signal Transduct Target Ther. 2020;5(1):288.

Article  PubMed  PubMed Central  Google Scholar 

Prada-Arismendy J, Arroyave JC, Röthlisberger S. Molecular biomarkers in acute myeloid leukemia. Blood Rev. 2017;31(1):63–76.

Article  CAS  PubMed  Google Scholar 

Shao R, Li Z, Xin H, et al. Biomarkers as targets for CAR-T/NK cell therapy in AML. Biomark Res. 2023;11(1):65.

Article  PubMed  PubMed Central  Google Scholar 

Ledford AW, Brantley JG, Kemeny G, et al. Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia. Dev Biol. 2002;245(1):157–71.

Article  CAS  PubMed  PubMed Central