Advances in Pharmacology and Pharmacy Vol. 12(3), pp. 149 - 163
DOI: 10.13189/app.2024.120301
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Dipanjan Mandal 1, Lopamudra Saha 1, Prerona Saha 2, Tapan Kumar Chatterjee 3,*
1 Department of Pharmacology, Guru Nanak Institute of Pharmaceutical Science and Technology, India
2 Department of Pharmaceutical Chemistry, Guru Nanak Institute of Pharmaceutical Science and Technology, India
3 School of Pharmaceutical Science and Technology, JIS University, India

ABSTRACT

In mammals, biological time plays an essential role in the rhythms of physiology and behavior. Circadian rhythm additionally optimizes the energy balance of the system and metabolic equilibrium. Disruption of biological time will affect this balance and might increase the chance of cardiometabolic disease and type II Diabetes. Obesity and the induction of metabolic disease may alter the temporal order and amplitude of the whole multiple-organ system, enhancing the disease progression. With the development of synergism between the molecular clock and metabolic disease, there is a growing focus and interest in novel clock-related pharmaceuticals and nutraceuticals for treating metabolic dysfunction. This review aims to highlight the importance of biological time within the development of type II diabetes mellitus concerning the clock genes and also the result of mutations of the clock genes that are found to manage glucose homeostasis condition within the system. Thus, this review explored the aspects of biological time and molecular clock that affect illness which might end in the development of Chronotherapy for the treatment of various metabolic diseases and diabetes mellitus.

KEYWORDS
Circadian, Clock Genes, Molecular Clock, Pharmaceutical, Chronotherapy

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Dipanjan Mandal , Lopamudra Saha , Prerona Saha , Tapan Kumar Chatterjee , "Prospects of Chronotherapy in the Treatment of Diabetes Mellitus: A Review," Advances in Pharmacology and Pharmacy, Vol. 12, No. 3, pp. 149 - 163, 2024. DOI: 10.13189/app.2024.120301.

(b). APA Format:
Dipanjan Mandal , Lopamudra Saha , Prerona Saha , Tapan Kumar Chatterjee (2024). Prospects of Chronotherapy in the Treatment of Diabetes Mellitus: A Review. Advances in Pharmacology and Pharmacy, 12(3), 149 - 163. DOI: 10.13189/app.2024.120301.