Advances in Pharmacology and Pharmacy Vol. 12(3), pp. 228 - 237
DOI: 10.13189/app.2024.120307
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Lavanya Thopireddy 1, Sathyavelu Reddy Kesireddy 2, Venkatramana Reddy A.T 3, Rajeswara Reddy Saddala 4,*
1 Department of Zoology, KVR Government College for Women (A), Cluster University, India
2 Department of Zoology, S.V. University, India
3 Department of Zoology, Yogi Vemana University, India
4 Division of Ethnopharmacology, Department of Biotechnology, School of Herbal and Naturo Sciences, Dravidian University, India

ABSTRACT

This study examines the effects of Pimpinella tirupatiensis (Pt) aqueous extract on diabetic rats produced by streptozotocin (STZ), looking at its anti-hyperglycemic, anti-oxidant, and anti-hyperlipidemic activities. Pimpinella tirupatiensis is an indigenous plant of India's Eastern Ghats, namely the Seshachalam mountains. Streptozotocin (40 mg/kg B.W.) was used to cause diabetes in male albino rats by dividing them into five groups of six animals each. The diabetic rats were administered oral doses of 750 mg/kg B.W., per day of Pimpinella tirupatiensis aqueous extract for thirty days. The results showed that the Pimpinella tirupatiensis aqueous extract possessed significantly anti-hyperglycemic, anti-hyperlipidemic, and anti-oxidant activity. Superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-s-transferase (GST) activity in the heart tissue of diabetic rats, which was decreased in comparison to normal, were likewise improved by aqueous extract treatment. Additionally, after receiving aqueous extract, the Catalase (CAT) activity, which was markedly elevated in diabetic rats, returned to normal. When diabetic rats were given aqueous extract, the levels of total cholesterol (TC), triglycerides (TGs), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), and VLDL cholesterol (VLDL-C) in their serum likewise returned to normal. These results imply that Pimpinella tirupatiensis aqueous extract is helpful in managing diabetes by lowering blood glucose levels and preventing oxidative stress by activating cardiac anti-oxidant enzymes.

KEYWORDS
Pimpinella tirupatiensis, Anti-hyperglycemic Activity, Anti-oxidant Activity, Anti-hyperlipidemic Activity, Streptozotocin

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Lavanya Thopireddy , Sathyavelu Reddy Kesireddy , Venkatramana Reddy A.T , Rajeswara Reddy Saddala , "An Investigation of the Hypoglycemic and Antioxidant Activity of Pimpinella tirupatiensis in STZ-Induced Diabetic Rat Cardiac Tissue," Advances in Pharmacology and Pharmacy, Vol. 12, No. 3, pp. 228 - 237, 2024. DOI: 10.13189/app.2024.120307.

(b). APA Format:
Lavanya Thopireddy , Sathyavelu Reddy Kesireddy , Venkatramana Reddy A.T , Rajeswara Reddy Saddala (2024). An Investigation of the Hypoglycemic and Antioxidant Activity of Pimpinella tirupatiensis in STZ-Induced Diabetic Rat Cardiac Tissue. Advances in Pharmacology and Pharmacy, 12(3), 228 - 237. DOI: 10.13189/app.2024.120307.