Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA. 2023;73:17–48.

PubMed  Google Scholar 

Wood LD, Canto MI, Jaffee EM, Simeone DM. Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment. Gastroenterology. 2022;163:386–402.e1.

Article  PubMed  Google Scholar 

Schizas D, Charalampakis N, Kole C, Economopoulou P, Koustas E, Gkotsis E, et al. Immunotherapy for pancreatic cancer: a 2020 update. Cancer Treatment Rev. 2020;86:102016.

Article  CAS  Google Scholar 

Springfeld C, Ferrone CR, Katz MHG, Philip PA, Hong TS, Hackert T, et al. Neoadjuvant therapy for pancreatic cancer. Nat Rev Clin Oncol. 2023;20:318–37.

Article  PubMed  Google Scholar 

Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 2020;21:475–90.

Article  CAS  PubMed  Google Scholar 

Wang X, Li J, Bian X, Wu C, Hua J, Chang S, et al. CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer. Proc Natl Acad Sci USA. 2021;118:e2012881118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao X, Xia X, Li F, Zhang M, Zhou H, Wu X, et al. Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling. Nat Cell Biol. 2021;23:278–91.

Article  CAS  PubMed  Google Scholar 

Meng L, Zhang Y, Wu P, Li D, Lu Y, Shen P, et al. CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2. Mol Cancer. 2022;21:121.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Li J, Shen P, Yuan H, Yin J, Ge W, et al. Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star. Cell Biosci. 2022;12:97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan B, Li X, Peng M, Zuo Y, Wang Y, Liu P, et al. The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression. Exp Mol Med. 2023;55:1145–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong X, He X, Wang Y, Hu Z, Huang H, Zhao S, et al. Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications. J Hematol Oncol. 2022;15:160.

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, et al. Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer. Br J Cancer. 2023;128:844–56.

Article  CAS  PubMed  Google Scholar 

Ligorio M, Sil S, Malagon-Lopez J, Nieman LT, Misale S, Di Pilato M, et al. Stromal microenvironment shapes the intratumoral architecture of pancreatic cancer. Cell. 2019;178:160–75.e27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, et al. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nat Commun. 2022;13:6513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu A, Xu J. Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1α axis. Clin Transl Oncol. 2021;23:1905–14.

Article  CAS  PubMed  Google Scholar 

Zheng D, Huang X, Peng J, Zhuang Y, Li Y, Qu J, et al. CircMYOF triggers progression and facilitates glycolysis via the VEGFA/PI3K/AKT axis by absorbing miR-4739 in pancreatic ductal adenocarcinoma. Cell Death Discov. 2021;7:362.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, et al. N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun. 2019;10:4695.

Article  PubMed  PubMed Central  Google Scholar 

Shi J, Rui X, Han C, Wang C, Xu L, Jiang X. circRNF13, a novel N(6)-methyladenosine-modified circular RNA, enhances radioresistance in cervical cancer by increasing CXCL1 mRNA stability. Cell Death Discov. 2023;9:253.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, He Y, Zhu J, Zhao S, Qi S, Chen X. et al. The roles and mechanism of m(6)A RNA methylation regulators in cancer immunity. Biomed Pharmacother. 2023;163:114839

Article  CAS  PubMed  Google Scholar 

Liu CX, Chen LL. Circular RNAs: characterization, cellular roles, and applications. Cell. 2022;185:2016–34.

Article  CAS  PubMed  Google Scholar 

Xia W, Chen W, Ni C, Meng X, Wu J, Yang Q, et al. Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway. Breast Cancer Res. 2023;25:85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martínez-Reyes I, Chandel NS. Cancer metabolism: looking forward. Nat Rev Cancer. 2021;21:669–80.

Article  PubMed  Google Scholar 

Kumari S, Khan S, Sekhri R, Mandil H, Behrman S, Yallapu MM, et al. Protein kinase D1 regulates metabolic switch in pancreatic cancer via modulation of mTORC1. Br J Cancer. 2020;122:121–31.

Article  CAS  PubMed  Google Scholar 

Wu L, Jin Y, Zhao X, Tang K, Zhao Y, Tong L, et al. Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α. Cell Metab. 2023;35:1580–1596.e9.

Article  CAS  PubMed  Google Scholar 

Luo H, Yu Q, Liu Y, Tang M, Liang M, Zhang D, et al. LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding. Sci Adv. 2020;6:eaaw4651.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen K, Hebert K, McConnell E, Cullen N, Cheng T, Awoyode S, et al. LKB1 signaling and patient survival outcomes in hepatocellular carcinoma. Pharmacol Res. 2023;192:106757.

Article  CAS  PubMed  Google Scholar 

Park JM, Lee DH, Kim DH. Redefining the role of AMPK in autophagy and the energy stress response. Nat Commun. 2023;14:2994.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao C, Wang B, Liu E, Zhang Z. Loss of PTEN expression is associated with PI3K pathway-dependent metabolic reprogramming in hepatocellular carcinoma. Cell Commun Signal. 2020;18:131.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glaviano A, Foo ASC, Lam HY, Yap KCH, Jacot W, Jones RH, et al. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer. 2023;22:138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding L, Zheng Q, Lin Y, Wang R, Wang H, Luo W, et al. Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage. Clin Transl Med. 2023;13:e1156.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su J, Li R, Chen Z, Liu S, Zhao H, Deng S, et al. N6-methyladenosine modification of FZR1 mRNA promotes gemcitabine resistance in pancreatic cancer. Cancer Res. 2023;83:3059–76.

Article  CAS  PubMed  Google Scholar 

Lu L, Zheng D, Qu J, Zhuang Y, Peng J, Lan S, et al. METTL16 predicts a favorable outcome and primes antitumor immunity in pancreatic ductal adenocarcinoma. Front Cell Dev Biol. 2022;10:759020.

Article  PubMed  PubMed Central  Google Scholar 

Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, et al. CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA. Mol Cancer. 2022;21:140.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang H, Weng H, Chen J. m(6)A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer. Cancer Cell. 2020;37:270–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, Wang Q, Zhao X, Shao L, Liu G, Zheng X. et al. YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA. Cell Death Dis. 2020;11:977

Article  CAS  PubMed 

留言 (0)

沒有登入
gif