*Research Division, Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Joslin Diabetes Center, Boston, Massachusetts;

†Beetham Eye Institute, Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Joslin Diabetes Center, Boston, Massachusetts;

‡Department of Ophthalmology, Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Harvard Medical School, Boston, Massachusetts; and

§Department of Medicine, Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Harvard Medical School, Boston, Massachusetts.

Reprint requests: George L. King MD, Research Division, Joslin Diabetes Center and Harvard Medical School, One Joslin Place, Boston, MA 02215; e-mail: [email protected]

American Diabetes Association (7-21-PDF-022), National Eye Institute (R01EYE26080-01), the National Institute of Diabetes and Digestive and Kidney Diseases and National Institutes of Health (DP3-DK-094333–01); JDRF (17-2013-310); the Dianne Nunnally Hoppes Fund; the Beatson Pledge Fund.

None of the authors has any financial/conflicting interests to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.drug-monitoring.com).

 W. Fickweiler and T. Chokshi contributed equally to this work.