*Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany;

†Amsterdam University Medical Center, Amsterdam, the Netherlands;

‡Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany;

§Department of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; and

¶Augenzentrum am St. Franziskus Hospital, Muenster, Germany.

Reprint requests: Felicitas Bucher, MD, Eye Center, Medical Center, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany; e-mail: [email protected]

This work and the MacTel Registry study are supported by the Lowy Medical Research Institute (LMRI). L. Pauleikhoff received a personal grant by the Deutsche Forschungsgemeinschaft, Bonn, Germany (Grant Pa 4282/1-1). L. Hannibal acknowledged research grants of the Federal Ministry of Economics and Technology (BMWi), grant Nr. 03THWBW002, and of the Scientific Society Freiburg im Breisgau. F. Bucher was supported by the Berta-Ottenstein Program for Clinician Scientists and Advanced Clinician Scientists of the Medical Faculty, University of Freiburg, the Deutsche Forschungsgemeinschaft, Bonn, Germany (Grant Bu 3135/3-1) and the Else-Kröner-Fresenius Stiftung (Grant 2021_EKEA.80).

None of the authors has any financial/conflicting interests to disclose.

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L. Hannibal and F. Bucher shared last authorship.