Trikudanathan S. Polycystic ovarian syndrome. Medical Clinics. 2015;99(1):221–35. https://doi.org/10.1016/j.mcna.2014.09.003.

Article  PubMed  Google Scholar 

Pourhoseini SA, Babazadeh R, Mazlom SR. Prevalence of Polycystic Ovary Syndrome in Iranian Adolescent Girls Based on Adults and Adolescents’ Diagnostic Criteria in Mashhad City. J Reprod Infertil. 2022;23(4):288–95. https://doi.org/10.18502/jri.v23i4.10815.

Article  PubMed  PubMed Central  Google Scholar 

Mehrabian F, Khani B, Kelishadi R, Ghanbari E. The prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria. Endokrynol Pol. 2011;62(3):238–42.

PubMed  Google Scholar 

Papadakis G, Kandaraki EA, Garidou A, Koutsaki M, Papalou O, Diamanti-Kandarakis E, et al. Tailoring treatment for PCOS phenotypes. Expert Rev Endocrinol Metab. 2021;16(1):9–18. https://doi.org/10.1080/17446651.2021.1865152.

Article  CAS  PubMed  Google Scholar 

Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. The Lancet. 2007;370(9588):685–97. https://doi.org/10.1016/S0140-6736(07)61345-2.

Article  CAS  Google Scholar 

Hoeger KM, Oberfield SE. Do women with PCOS have a unique predisposition to obesity? Fertil Steril. 2012;97(1):13–7. https://doi.org/10.1016/j.fertnstert.2011.11.026.

Article  PubMed  Google Scholar 

Stamets K, Taylor DS, Kunselman A, Demers LM, Pelkman CL, Legro RS. A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome. Fertil Steril. 2004;81(3):630–7. https://doi.org/10.1016/j.fertnstert.2003.08.023.

Article  CAS  PubMed  Google Scholar 

Moran LJ, Noakes M, Clifton PM, Wittert GA, Williams G, Norman RJ. Short-term meal replacements followed by dietary macronutrient restriction enhance weight loss in polycystic ovary syndrome. Am J Clin Nutr. 2006;84(1):77–87. https://doi.org/10.1093/ajcn/84.1.77.

Article  CAS  PubMed  Google Scholar 

Tsagareli V, Noakes M, Norman RJ. Effect of a very-low-calorie diet on in vitro fertilization outcomes. Fertil Steril. 2006;86(1):227–9. https://doi.org/10.1016/j.fertnstert.2005.12.041.

Article  PubMed  Google Scholar 

Paoli A. Ketogenic diet for obesity: friend or foe? Int J Environ Res Public Health. 2014;11(2):2092–107. https://doi.org/10.3390/ijerph110202092.

Article  PubMed  PubMed Central  Google Scholar 

Paoli A, Bianco A, Grimaldi KA. The ketogenic diet and sport: a possible marriage? Exerc Sport Sci Rev. 2015;43(3):153–62. https://doi.org/10.1249/JES.0000000000000050.

Article  PubMed  Google Scholar 

Muscogiuri G, Barrea L, Laudisio D, Pugliese G, Salzano C, Savastano S, et al. The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide. J Transl Med. 2019;17:1–9. https://doi.org/10.1186/s12967-019-2104-z.

Article  Google Scholar 

Cincione IR, Graziadio C, Marino F, Vetrani C, Losavio F, Savastano S, et al. Short-time effects of ketogenic diet or modestly hypocaloric Mediterranean diet on overweight and obese women with polycystic ovary syndrome. J Endocrinol Invest. 2023;46(4):769–77. https://doi.org/10.1007/s40618-022-01943-y.

Article  CAS  PubMed  Google Scholar 

Li J, Bai WP, Jiang B, Bai LR, Gu B, Yan SX, et al. Ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese: a randomized, open-label, parallel-group, controlled pilot trial. Journal of Obstetrics and Gynaecology Research. 2021;47(3):1145–52. https://doi.org/10.1111/jog.14650.

Article  CAS  PubMed  Google Scholar 

Pandurevic S, Dionese P, Mancini I, Mitselman D, Magagnoli M, Teglia R, et al. Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study. Endocr Abstr. 2022. https://doi.org/10.1530/endoabs.81.P193.

Article  Google Scholar 

Khalid K, Apparow S, Mushaddik IL, Anuar A, Rizvi SAA, Habib A. Effects of ketogenic diet on reproductive hormones in women with polycystic ovary syndrome. J Endocr Soc. 2023;7(10):bvad112. https://doi.org/10.1210/jendso/bvad112.

Liu S, Yao Q, Li X, Wu H, Sun C, Bai W, et al. Effects of a ketogenic diet on reproductive and metabolic phenotypes in mice with polycystic ovary syndrome†. Biol Reprod. 2023;108(4):597–610. https://doi.org/10.1093/biolre/ioad004.

Article  PubMed  Google Scholar 

Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Bmj. 2011;343. https://doi.org/10.1136/bmj.d5928

Ma LL, Wang YY, Yang ZH, Huang D, Weng H, Zeng XT. Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Mil Med Res. 2020;7(1):7. https://doi.org/10.1186/s40779-020-00238-8.

Article  PubMed  PubMed Central  Google Scholar 

Cincione RI, Losavio F, Ciolli F, Valenzano A, Cibelli G, Messina G, et al. Effects of mixed of a ketogenic diet in overweight and obese women with polycystic ovary syndrome. Int J Environ Res Public Health. 2021;18(23): 12490. https://doi.org/10.3390/ijerph182312490.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avolio E, Ferraro S, Mocciaro R, De Pergola G, Buzzanca F, Venturella R, et al. The effect of ketogenic and low carb diet (Cyclic Alternation) on the ovarian morphology and insulin metabolism in polycystic ovary syndrome patients. Clin Obstet Gynecol. 2020;6:1–6. https://doi.org/10.15761/COGRM.1000307.

Mavropoulos JC, Yancy WS, Hepburn J, Westman EC. The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. Nutr Metab. 2005;2(1):1–5. https://doi.org/10.1186/1743-7075-2-35.

Article  CAS  Google Scholar 

Jian LI, Wenpei BAI, Bo J, Feiran LIU, Yanrong C. Effects of ketogenic diet on vitamin D and glycolipid metabolism in overweight or obese patients with polycystic ovary syndrome. Journal of Clinical Medicine in Practice. 2022;26(4):14–7. https://doi.org/10.7619/jcmp.20220496.

Article  CAS  Google Scholar 

Magagnini MC, Condorelli RA, Cimino L, Cannarella R, Aversa A, Calogero AE, et al. Does the Ketogenic Diet Improve the Quality of Ovarian Function in Obese Women? Nutrients. 2022;14(19): 4147. https://doi.org/10.3390/nu14194147.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paoli A, Mancin L, Giacona MC, Bianco A, Caprio M. Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Transl Med. 2020;18(1):1–11. https://doi.org/10.1186/s12967-020-02277-0.

Article  CAS  Google Scholar 

Khalid R, Jabeen S, Farooq S, Abid F. Influence of ketogenic mediterranean with phytoextracts diet on hyperandrogenism markers in married women with polycystic ovarian syndrome.

Pandurevic S, Mancini I, Mitselman D, Magagnoli M, Teglia R, Fazzeri R, et al. Efficacy of very low-calorie ketogenic diet with the Pronokal® method in obese women with polycystic ovary syndrome: a 16-week randomized controlled trial. Endocri Connect. 2023;1(aop). 10.1530.

Magagnini MC, Condorelli RA, Cimino L, Cannarella R, Aversa A, Calogero AE, et al. Does the Ketogenic Diet Improve the Quality of Ovarian Function in Obese Women? Nutrients. 2022;14(19). https://doi.org/10.3390/nu14194147

Muscogiuri G, Colao A, Orio F. Insulin-Mediated Diseases: Adrenal Mass and Polycystic Ovary Syndrome. Trends Endocrinol Metab. 2015;26(10):512–4. https://doi.org/10.1016/j.tem.2015.07.010.

Article  CAS  PubMed  Google Scholar 

Haffner SM, Katz MS, Stern MP, Dunn JF. The relationship of sex hormones to hyperinsulinemia and hyperglycemia. Metabolism. 1988;37(7):683–8. https://doi.org/10.1016/0026-0495(88)90091-1.

Article  CAS  PubMed  Google Scholar 

Barrea L, Frias-Toral E, Verde L, Ceriani F, Cucalón G, Garcia-Velasquez E, et al. PCOS and nutritional approaches: Differences between lean and obese phenotype. Metabol Open. 2021;12: 100123. https://doi.org/10.1016/j.metop.2021.100123.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barrea L, Marzullo P, Muscogiuri G, Di Somma C, Scacchi M, Orio F, et al. Source and amount of carbohydrate in the diet and inflammation in women with polycystic ovary syndrome. Nutr Res Rev. 2018;31(2):291–301. https://doi.org/10.1017/S0954422418000136.

Article  CAS  PubMed  Google Scholar 

Masood W, Annamaraju P, Uppaluri KR. Ketogenic diet. StatPearls [Internet]: StatPearls Publishing; 2022.

Mohorko N, Černelič-Bizjak M, Poklar-Vatovec T, Grom G, Kenig S, Petelin A, et al. Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults. Nutr Res. 2019;62:64–77. https://doi.org/10.1016/j.nutres.2018.11.007.

Article  CAS  PubMed  Google Scholar 

Gjuladin-Hellon T, Davies IG, Penson P, Amiri BR. Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis. Nutr Rev. 2019;77(3):161–80. https://doi.org/10.1093/nutrit/nuy049.

Article  PubMed  Google Scholar 

Lu M, Wan Y, Yang B, Huggins CE, Li D. Effects of low-fat compared with high-fat diet on cardiometabolic indicators in people with overweight and obesity without overt metabolic disturbance: a systematic review and meta-analysis of randomised controlled trials. Br J Nutr. 2018;119(1):96–108. https://doi.org/10.1017/S0007114517002902.

Article  CAS  PubMed  Google Scholar 

Schwingshackl L, Hoffmann G. Comparison of effects of long-term low-fat vs high-fat diets on blood lipid levels in overweight or obese patients: a systematic review and meta-analysis. J Acad Nutr Diet. 2013;113(12):1640–61. https://doi.org/10.1016/j.jand.2013.07.010.

Article  PubMed  Google Scholar 

Valenzano A, Polito R, Trimigno V, Di Palma A, Moscatelli F, Corso G, et al. Effects of very low calorie ketogenic diet on the orexinergic system, visceral adipose tissue, and ROS production. Antioxidants. 2019;8(12): 643. https://doi.org/10.3390/antiox8120643.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monda V, Polito R, Lovino A, Finaldi A, Valenzano A, Nigro E, et al. Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States. Int J Mol Sci. 2020;21(9). https://doi.org/10.3390/ijms21093228.

Ma S, Suzuki K. Keto-adaptation and endurance exercise capacity, fatigue recovery, and exercise-induced muscle and organ damage prevention: a narrative review. Sports (Basel). 2019;7(2). https://doi.org/10.3390/sports7020040.

Oh R, Uppaluri KR. Low carbohydrate diet. StatPearls. Treasure Island: StatPearls Publishing; 2020.