de Groot PM, Wu CC, Carter BW, Munden RF. The epidemiology of lung cancer. Transl Lung Cancer Res. 2018;7:220–33.
Article PubMed PubMed Central Google Scholar
Siegel RL, Miller KD, Fuchs HE, Jemal A, Cancer Statistics. 2021. CA: A Cancer Journal for Clinicians. 2021;71:7–33.
White JF, Noinaj N, Shibata Y, et al. Structure of the agonist-bound neurotensin receptor. Nature. 2012;490:508–13.
Article CAS PubMed PubMed Central Google Scholar
Wu Z, Martinez-Fong D, Trédaniel J, Forgez P. Neurotensin and its high affinity receptor 1 as a potential pharmacological target in cancer therapy. Front Endocrinol (Lausanne). 2012;3:184.
Goedert M, Reeve JG, Emson PC, Bleehen NM. Neurotensin in human small cell lung carcinoma. Br J Cancer. 1984;50:179–83.
Article CAS PubMed PubMed Central Google Scholar
Vincent JP, Mazella J, Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol Sci. 1999;20:302–9.
Article CAS PubMed Google Scholar
Mazella J, Vincent J-P. Functional roles of the NTS2 and NTS3 receptors. Peptides. 2006;27:2469–75.
Article CAS PubMed Google Scholar
Ehlers RA, Bonnor RM, Wang X, Hellmich MR, Evers BM. Signal transduction mechanisms in neurotensin-mediated cellular regulation. Surgery. 1998;124:239–47.
Ehlers RA, Zhang Y, Hellmich MR, Evers BM. Neurotensin-mediated activation of MAPK pathways and AP-1 binding in the human pancreatic cancer cell line, MIA PaCa-2. Biochem Biophys Res Commun. 2000;269:704–8.
Article CAS PubMed Google Scholar
Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C. Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer. 2007;120:1652–6.
Article CAS PubMed PubMed Central Google Scholar
Christou N, Blondy S, David V, et al. Neurotensin pathway in digestive cancers and clinical applications: an overview. Cell Death Dis. 2020;11:1–12.
Ouyang Q, Zhou J, Yang W, Cui H, Xu M, Yi L. Oncogenic role of neurotensin and neurotensin receptors in various cancers. Clin Exp Pharmacol Physiol. 2017;44:841–6.
Article CAS PubMed Google Scholar
Dupouy S, Mourra N, Doan VK, Gompel A, Alifano M, Forgez P. The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers. Biochimie. 2011;93:1369–78.
Article CAS PubMed Google Scholar
Ocejo-Garcia M, Ahmed SI, Coulson JM, Woll PJ. Use of RT-PCR to detect co-expression of neuropeptides and their receptors in lung cancer. Lung Cancer. 2001;33:1–9.
Article CAS PubMed Google Scholar
Younes M, Wu Z, Dupouy S, et al. Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib. Oncotarget. 2014;5:8252–69.
Article PubMed PubMed Central Google Scholar
Alifano M, Souazé F, Dupouy S, et al. Neurotensin receptor 1 determines the outcome of non-small cell lung cancer. Clin Cancer Res. 2010;16:4401–10.
Article CAS PubMed Google Scholar
Moody TW, Chiles J, Casibang M, Moody E, Chan D, Davis TP. SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells. Peptides. 2001;22:109–15.
Article CAS PubMed Google Scholar
Reubi JC, Waser B, Friess H, Büchler M, Laissue J. Neurotensin receptors: a new marker for human ductal pancreatic adenocarcinoma. Gut. 1998;42:546–50.
Article CAS PubMed PubMed Central Google Scholar
Seethalakshmi L, Mitra SP, Dobner PR, Menon M, Carraway RE. Neurotensin receptor expression in prostate cancer cell line and growth effect of NT at physiological concentrations. Prostate. 1997;31:183–92.
Article CAS PubMed Google Scholar
Souazé F, Dupouy S, Viardot-Foucault V, et al. Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression. Cancer Res. 2006;66:6243–9.
Maoret JJ, Pospaï D, Rouyer-Fessard C, et al. Neurotensin receptor and its mRNA are expressed in many human colon cancer cell lines but not in normal colonic epithelium: binding studies and RT-PCR experiments. Biochem Biophys Res Commun. 1994;203:465–71.
Article CAS PubMed Google Scholar
Achilefu S, Srinivasan A, Schmidt MA, Jimenez HN, Bugaj JE, Erion JL. Novel bioactive and Stable Neurotensin Peptide Analogues Capable of Delivering Radiopharmaceuticals and Molecular beacons to tumors. J Med Chem. 2003;46:3403–11.
Article CAS PubMed Google Scholar
Bergmann R, Scheunemann M, Heichert C, et al. Biodistribution and catabolism of 18F-labeled neurotensin (8–13) analogs. Nucl Med Biol. 2002;29:61–72.
Article CAS PubMed Google Scholar
Teodoro R, Faintuch BL, Núñez EGF, Queiróz RG. Neurotensin (8–13) analogue: radiolabeling and biological evaluation using different chelators. Nucl Med Biol. 2011;38:113–20.
Article CAS PubMed Google Scholar
Buchegger F, Bonvin F, Kosinski M, et al. Radiolabeled neurotensin analog, 99mTc-NT-XI, evaluated in ductal pancreatic adenocarcinoma patients. J Nucl Med. 2003;44:1649–54.
Zhang K, An R, Gao Z, Zhang Y, Aruva MR. Radionuclide imaging of small-cell lung cancer (SCLC) using 99mTc-labeled neurotensin peptide 8–13. Nucl Med Biol. 2006;33:505–12.
Article CAS PubMed Google Scholar
García-Garayoa E, Bläuenstein P, Blanc A, Maes V, Tourwé D, Schubiger PA. A stable neurotensin-based radiopharmaceutical for targeted imaging and therapy of neurotensin receptor-positive tumours. Eur J Nucl Med Mol Imaging. 2009;36:37–47.
de Visser M, Janssen PJJM, Srinivasan A, et al. Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer. Eur J Nucl Med Mol Imaging. 2003;30:1134–9.
Wu Z, Liu S, Nair I, et al. 64Cu labeled Sarcophagine Exendin-4 for MicroPET Imaging of Glucagon like Peptide-1 receptor expression. Theranostics. 2014;4:770–7.
Article CAS PubMed PubMed Central Google Scholar
Wu Z, Li L, Liu S, et al. Facile Preparation of a thiol-reactive (18)F-Labeling Agent and Synthesis of (18)F-DEG-VS-NT for PET Imaging of a Neurotensin receptor-positive tumor. J Nucl Med. 2014;55:1178–84.
Article CAS PubMed Google Scholar
Deng H, Wang H, Wang M, Li Z, Wu Z. Synthesis and evaluation of 64Cu-DOTA-NT-Cy5.5 as a dual-modality PET/Fluorescence probe to Image Neurotensin receptor-positive tumor. Mol Pharm. 2015;12:3054–61.
Article CAS PubMed PubMed Central Google Scholar
Alshoukr F, Prignon A, Brans L, et al. Novel DOTA-neurotensin analogues for 111In scintigraphy and 68Ga PET imaging of neurotensin receptor-positive tumors. Bioconjug Chem. 2011;22:1374–85.
Article CAS PubMed Google Scholar
Deng H, Wang H, Zhang H, et al. Imaging neurotensin receptor in prostate Cancer with 64Cu-Labeled neurotensin analogs. Mol Imaging. 2017;16:1536012117711369.
Article PubMed PubMed Central Google Scholar
Gully D, Canton M, Boigegrain R, et al. Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc Natl Acad Sci U S A. 1993;90:65–9.
Article CAS PubMed PubMed Central Google Scholar
Myers RM, Shearman JW, Kitching MO, Ramos-Montoya A, Neal DE, Ley SV. Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors. ACS Chem Biol. 2009;4:503–25.
Article CAS PubMed Google Scholar
Gully D, Labeeuw B, Boigegrain R, et al. Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther. 1997;280:802–12.
Betancur C, Canton M, Burgos A, et al. Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain. Eur J Pharmacol. 1998;343:67–77.
Article CAS PubMed Google Scholar
Schaeffer P, Laplace MC, Bernat A, et al. SR142948A is a potent antagonist of the cardiovascular effects of neurotensin. J Cardiovasc Pharmacol. 1998;31:545–50.
留言 (0)