Baraz L, Haupt Y, Elkin M, Peretz T, Vlodavsky I (2006) Tumor suppressor p53 regulates heparanase gene expression. Oncogene 25:3939–3947. https://doi.org/10.1038/sj.onc.1209425
Article CAS PubMed Google Scholar
Brosh R, Rotter V (2009) When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 9:701–713. https://doi.org/10.1038/nrc2693
Article CAS PubMed Google Scholar
Chen Z, Zhu L, Li X, Tian H, Fang Y, Liu H, Li S, Li L, Yue W, Li W (2013) Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo. Acta Biochim Biophys Sin 45:188–193. https://doi.org/10.1093/abbs/gms109
Article CAS PubMed Google Scholar
Chen X, Kang R, Kroemer G, Tang D (2021) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18:280–296. https://doi.org/10.1038/s41571-020-00462-0
Article CAS PubMed Google Scholar
Cohen E, Doweck I, Naroditsky I, Ben-Izhak O, Kremer R, Best LA, Vlodavsky I, Ilan N (2008) Heparanase is overexpressed in lung cancer and correlates inversely with patient survival. Cancer 113:1004–1011. https://doi.org/10.1002/cncr.23680
Cohen-Kaplan V, Naroditsky I, Zetser A, Ilan N, Vlodavsky I, Doweck I (2008) Heparanase induces VEGF C and facilitates tumor lymphangiogenesis. Int J Cancer 123:2566–2573. https://doi.org/10.1002/ijc.23898
Article CAS PubMed PubMed Central Google Scholar
Custodio AB, González-Larriba JL, Bobokova J, Calles A, Alvarez R, Cuadrado E, Manzano A, Díaz-Rubio E (2009) Prognostic and predictive markers of benefit from adjuvant chemotherapy in early-stage non-small cell lung cancer. J Thorac Oncol Off Publ Int Assoc Study Lung Cancer 4:891–910. https://doi.org/10.1097/JTO.0b013e3181a4b8fb
Fridman JS, Lowe SW (2003) Control of apoptosis by p53. Oncogene 22:9030–9040. https://doi.org/10.1038/sj.onc.1207116
Article CAS PubMed Google Scholar
Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W (2015) Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520:57–62. https://doi.org/10.1038/nature14344
Article CAS PubMed PubMed Central Google Scholar
Kim YW, Byzova TV (2014) Oxidative stress in angiogenesis and vascular disease. Blood 123:625–631. https://doi.org/10.1182/blood-2013-09-512749
Article CAS PubMed PubMed Central Google Scholar
Kim MG, Jo SD, Yhee JY, Lee BS, Lee SJ, Park SG, Kang SW, Kim SH, Jeong JH (2017) Synergistic anti-tumor effects of bevacizumab and tumor targeted polymerized VEGF siRNA nanoparticles. Biochem Biophys Res Commun 489:35–41. https://doi.org/10.1016/j.bbrc.2017.05.103
Article CAS PubMed Google Scholar
Kuganesan N, Dlamini S, Tillekeratne LMV, Taylor WR (2021) Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F. J Biol Chem 297:101365. https://doi.org/10.1016/j.jbc.2021.101365
Article CAS PubMed PubMed Central Google Scholar
Lei B, Qi W, Zhao Y, Li Y, Liu S, Xu X, Zhi C, Wan L, Shen H (2015) PBK/TOPK expression correlates with mutant p53 and affects patients’ prognosis and cell proliferation and viability in lung adenocarcinoma. Hum Pathol 46:217–224. https://doi.org/10.1016/j.humpath.2014.07.026
Article CAS PubMed Google Scholar
Liu G, Chen X (2006) Regulation of the p53 transcriptional activity. J Cell Biochem 97:448–458. https://doi.org/10.1002/jcb.20700
Article CAS PubMed Google Scholar
Liu Y, Gu W (2022) p53 in ferroptosis regulation: the new weapon for the old guardian. Cell Death Differ 29:895–910. https://doi.org/10.1038/s41418-022-00943-y
Article CAS PubMed PubMed Central Google Scholar
Liu X, Lin XJ, Wang CP, Yan KK, Zhao LY, An WX, Liu XD (2014) Association between smoking and p53 mutation in lung cancer: a meta-analysis. Clin Oncol (royal College of Radiologists (great Britain)) 26:18–24. https://doi.org/10.1016/j.clon.2013.09.003
Lv B, Zhang B, Hu XY, Zeng QD (2016) Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic ductal cell adenocarcinoma. Oncol Lett 11:1327–1334. https://doi.org/10.3892/ol.2016.4085
Article CAS PubMed PubMed Central Google Scholar
Lv Q, Wu K, Liu F, Wu W, Chen Y, Zhang W (2018) Interleukin-17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer. Int J Oncol 53:1809–1817. https://doi.org/10.3892/ijo.2018.4503
Article CAS PubMed Google Scholar
Martinez-Outschoorn UE, Lin Z, Trimmer C, Flomenberg N, Wang C, Pavlides S, Pestell RG, Howell A, Sotgia F, Lisanti MP (2011) Cancer cells metabolically “fertilize” the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors. Cell Cycle (Georgetown, Tex.) 10:2504–2520. https://doi.org/10.4161/cc.10.15.16585
Article CAS PubMed Google Scholar
Masola V, Bellin G, Gambaro G, Onisto M (2018) Heparanase: a multitasking protein involved in extracellular matrix (ECM) remodeling and intracellular events. Cells. https://doi.org/10.3390/cells7120236
Article PubMed PubMed Central Google Scholar
Masola V, Zaza G, Gambaro G, Franchi M, Onisto M (2020) Role of heparanase in tumor progression: molecular aspects and therapeutic options. Semin Cancer Biol 62:86–98. https://doi.org/10.1016/j.semcancer.2019.07.014
Article CAS PubMed Google Scholar
Mogi A, Kuwano H (2011) TP53 mutations in nonsmall cell lung cancer. J Biomed Biotechnol 2011:583929. https://doi.org/10.1155/2011/583929
Article CAS PubMed PubMed Central Google Scholar
Oren M, Rotter V (2010) Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol 2:a001107. https://doi.org/10.1101/cshperspect.a001107
Article CAS PubMed PubMed Central Google Scholar
Ou Y, Wang SJ, Li D, Chu B, Gu W (2016) Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci USA 113:E6806-e6812. https://doi.org/10.1073/pnas.1607152113
Article CAS PubMed PubMed Central Google Scholar
Peng M, Hu Q, Wu Z, Wang B, Wang C, Yu F (2023) Mutation of TP53 confers ferroptosis resistance in lung cancer through the FOXM1/MEF2C axis. Am J Pathol 193:1587–1602. https://doi.org/10.1016/j.ajpath.2023.05.003
Article CAS PubMed Google Scholar
Prieto-Bermejo R, Hernández-Hernández A (2017) The importance of NADPH oxidases and redox signaling in angiogenesis. Antioxidants (Basel, Switzerland). https://doi.org/10.3390/antiox6020032
Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC, Sanderson RD (2010) Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Blood 115:2449–2457. https://doi.org/10.1182/blood-2009-07-234757
Article CAS PubMed PubMed Central Google Scholar
Qadir A, Khalid Z, Kashan Theba F, Mujtaba Ali M, Asif M, Rizvi F (2023) Celecoxib and bevacizumab synergistically inhibit non-small cell lung cancer by inducing apoptosis and modulating VEGF and MMP-9 expression. Pak J Pharm Sci 36:501–506
Tang B, Yang S (2020) Involvement of heparanase in gastric cancer progression and immunotherapy. Adv Exp Med Biol 1221:351–363. https://doi.org/10.1007/978-3-030-34521-1_13
Article CAS PubMed Google Scholar
Tang Z, Jiang W, Mao M, Zhao J, Chen J, Cheng N (2021) Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin. Clin Transl Med 11:e390. https://doi.org/10.1002/ctm2.390
Article CAS PubMed PubMed Central Google Scholar
Tarangelo A, Magtanong L, Bieging-Rolett KT, Li Y, Ye J, Attardi LD, Dixon SJ (2018) p53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep 22:569–575. https://doi.org/10.1016/j.celrep.2017.12.077
Article CAS PubMed PubMed Central Google Scholar
Tsao MS, Aviel-Ronen S, Ding K, Lau D, Liu N, Sakurada A, Whitehead M, Zhu CQ, Livingston R, Johnson DH, Rigas J, Seymour L, Winton T, Shepherd FA (2007) Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer. J Clin Oncol off J Am Soc Clin Oncol 25:5240–5247. https://doi.org/10.1200/jco.2007.12.6953
Vlodavsky I, Singh P, Boyango I, Gutter-Kapon L, Elkin M, Sanderson RD, Ilan N (2016) Heparanase: from basic research to therapeutic applications in cancer and inflammation. Drug Resistance Updates Rev Comment Antimicrob Anticancer Chemother 29:54–75. https://doi.org/10.1016/j.drup.2016.10.001
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