This study was funded by National Natural Sciences Foundation of China [82271280 to YT and 82301433 to JJW], Hunan Provincial Natural Science Foundation of China [No. 2022JJ40824 to JJW], Scientific Research Project of Hunan Provincial Health Commission [No. B202303070054 to YT], Talents Startup Fund [No. 2209090550 to YT], Youth Science Fund [No. 2021Q04 to JJW] and Project Program of National Clinical Research Center for Geriatric Disorders [No. 2022LNJJ14 to HJZ] of Xiangya Hospital, Central South University, Changsha, China.