Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.
Bekelman JE, Rumble RB, Chen RC, Pisansky TM, Finelli A, Feifer A, et al. Clinically Localized Prostate Cancer: ASCO Clinical Practice Guideline Endorsement of an American Urological Association/American Society for Radiation Oncology/Society of Urologic Oncology Guideline. J Clin Oncol. 2018;36:3251–8.
Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med. 2015;373:737–46.
Article CAS PubMed PubMed Central Google Scholar
Hahn AW, Siddiqui BA, Leo J, Dondossola E, Basham KJ, Miranti CK, et al. Cancer cell-extrinsic roles for the androgen receptor in prostate cancer. Endocrinology. 2023;164:bqad078.
Gillette CM, Yette GA, Cramer SD, Graham LS. Management of advanced prostate cancer in the precision oncology era. Cancers (Basel). 2023;15:2552.
Article CAS PubMed Google Scholar
Watson PA, Arora VK, Sawyers CL. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat Rev Cancer. 2015;15:701–11.
Article CAS PubMed PubMed Central Google Scholar
Karantanos T, Corn PG, Thompson TC. Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches. Oncogene. 2013;32:5501–11.
Article CAS PubMed PubMed Central Google Scholar
Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017;36:1461–73.
Article CAS PubMed Google Scholar
Wang L, Dehm SM, Hillman DW, Sicotte H, Tan W, Gormley M, et al. A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone. Ann Oncol. 2018;29:352–60.
Article CAS PubMed Google Scholar
Isaacsson Velho P, Fu W, Wang H, Mirkheshti N, Qazi F, Lima FAS, et al. Wnt-pathway activating mutations are associated with resistance to first-line abiraterone and enzalutamide in castration-resistant prostate cancer. European Urology. 2020;77:14–21.
Article CAS PubMed Google Scholar
Patel R, Brzezinska EA, Repiscak P, Ahmad I, Mui E, Gao M, et al. Activation of β-catenin cooperates with loss of pten to drive AR-independent castration-resistant prostate cancer. Cancer Res. 2020;80:576–90.
Article CAS PubMed Google Scholar
Hayat R, Manzoor M, Hussain A. Wnt signaling pathway: a comprehensive review. Cell Biol Int. 2022;46:863–77.
Article CAS PubMed Google Scholar
Kagey MH, He X. Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology. Br J Pharmacol. 2017;174:4637–50.
Article CAS PubMed PubMed Central Google Scholar
Jiang H, Zhang Z, Yu Y, Chu HY, Yu S, Yao S, et al. Drug discovery of DKK1 inhibitors. Front Pharmacol. 2022;13:847387.
Article CAS PubMed PubMed Central Google Scholar
Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med. 2003;349:2483–94.
Article CAS PubMed Google Scholar
Liu Y, Tang W, Xie L, Wang J, Deng Y, Peng Q, et al. Prognostic significance of dickkopf-1 overexpression in solid tumors: a meta-analysis. Tumour Biol. 2014;35:3145–54.
Article CAS PubMed Google Scholar
Sheng SL, Huang G, Yu B, Qin WX. Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer. Clin Chem. 2009;55:1656–64.
Kim SU, Park JH, Kim HS, Lee JM, Lee HG, Kim H, et al. Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma. Yonsei Med J. 2015;56:1296–306.
Article CAS PubMed PubMed Central Google Scholar
Jiang T, Huang L, Zhang S. DKK-1 in serum as a clinical and prognostic factor in patients with cervical cancer. Int J Biol Markers. 2013;28:221–5.
Article CAS PubMed Google Scholar
Aguilera O, Fraga MF, Ballestar E, Paz MF, Herranz M, Espada J, et al. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene. 2006;25:4116–21.
Article CAS PubMed Google Scholar
Mikheev AM, Mikheeva SA, Maxwell JP, Rivo JV, Rostomily R, Swisshelm K, et al. Dickkopf-1 mediated tumor suppression in human breast carcinoma cells. Breast Cancer Res Treat. 2008;112:263–73.
Article CAS PubMed Google Scholar
Cho SW, Lee EJ, Kim H, Kim SH, Ahn HY, Kim YA, et al. Dickkopf-1 inhibits thyroid cancer cell survival and migration through regulation of β-catenin/E-cadherin signaling. Mol Cell Endocrinol. 2013;366:90–8.
Article CAS PubMed Google Scholar
Thudi NK, Martin CK, Murahari S, Shu ST, Lanigan LG, Werbeck JL, et al. Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases. Prostate. 2011;71:615–25.
Article CAS PubMed Google Scholar
Rachner TD, Thiele S, Göbel A, Browne A, Fuessel S, Erdmann K, et al. High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients. BMC Cancer. 2014;14:649.
Article PubMed PubMed Central Google Scholar
D’Amelio P, Roato I, Oderda M, Soria F, Zitella A, Ferracini R, et al. DKK-1 in prostate cancer diagnosis and follow up. BMC Clin Pathol. 2014;14:11.
Article PubMed PubMed Central Google Scholar
Hall CL, Daignault SD, Shah RB, Pienta KJ, Keller ET. Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis. Prostate. 2008;68:1396–404.
Article PubMed PubMed Central Google Scholar
Rinella L, Marano F, Paletto L, Fraccalvieri M, Annaratone L, Castellano I, et al. Extracorporeal shock waves trigger tenogenic differentiation of human adipose-derived stem cells. Connect Tissue Res. 2018;59:561–73.
Article CAS PubMed Google Scholar
Roato I, D’Amelio P, Gorassini E, Grimaldi A, Bonello L, Fiori C, et al. Osteoclasts are active in bone forming metastases of prostate cancer patients. PLoS ONE. 2008;3:e3627.
Article PubMed PubMed Central Google Scholar
Giralt I, Gallo-Oller G, Navarro N, Zarzosa P, Pons G, Magdaleno A, et al. Dickkopf-1 inhibition reactivates Wnt/β-catenin signaling in rhabdomyosarcoma, induces myogenic markers in vitro and impairs tumor cell survival in vivo. IJMS. 2021;22:12921.
Article CAS PubMed PubMed Central Google Scholar
Hall CL, Zhang H, Baile S, Ljungman M, Kuhstoss S, Keller ET. p21CIP-1/WAF-1 induction is required to inhibit prostate cancer growth elicited by deficient expression of the Wnt inhibitor Dickkopf-1. Cancer Res. 2010;70:9916–26.
Article CAS PubMed PubMed Central Google Scholar
Wang Z, Wang J, Chen Z, Wang K, Shi L. MicroRNA-1-3p inhibits the proliferation and migration of oral squamous cell carcinoma cells by targeting DKK1. Biochem Cell Biol. 2018;96:355–64.
Article CAS PubMed Google Scholar
Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H. Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth. Int J Cancer. 2010;126:1611–20.
Article CAS PubMed Google Scholar
Qi L, Sun B, Liu Z, Li H, Gao J, Leng X. Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression. Cancer Sci. 2012;103:828–35.
Article CAS PubMed PubMed Central Google Scholar
Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol. 2011;12:385–92.
Article CAS PubMed Google Scholar
Vakifahmetoglu H, Olsson M, Zhivotovsky B. Death through a tragedy: mitotic catastrophe. Cell Death Differ. 2008;15:1153–62.
Article CAS PubMed Google Scholar
Kim S, Min A, Lee KH, Yang Y, Kim TY, Lim JM, et al. Antitumor effect of KX-01 through inhibiting Src family kinases and mito
留言 (0)