Abais-Battad JM, Alsheikh AJ, Pan X et al (2019) Dietary effects on dahl salt-sensitive hypertension, renal damage, and the t lymphocyte transcriptome. Hypertension 74:854–863. https://doi.org/10.1161/HYPERTENSIONAHA.119.12927

Article  CAS  PubMed  Google Scholar 

Cheng Y, Zhang J, Guo W et al (2016) Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy. Free Radic Biol Med 93:94–109. https://doi.org/10.1016/j.freeradbiomed.2016.02.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chung HJ (2014) The role of Randall plaques on kidney stone formation. Transl Androl Urol 3:251–254. https://doi.org/10.3978/j.issn.2223-4683.2014.07.03

Article  PubMed  PubMed Central  Google Scholar 

D’Costa MR, Haley WE, Mara KC et al (2019) Symptomatic and radiographic manifestations of kidney stone recurrence and their prediction by risk factors: a prospective cohort study. J Am Soc Nephrol 30:1251–1260. https://doi.org/10.1681/ASN.2018121241

Article  PubMed  PubMed Central  Google Scholar 

Dong C, Song C, He Z et al (2023) Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3beta/Nrf2 signaling-mediated ferroptosis in vivo and in vitro. Int Immunopharmacol 117:110042. https://doi.org/10.1016/j.intimp.2023.110042

Article  CAS  PubMed  Google Scholar 

Feng Q, Yang Y, Qiao Y et al (2023) Quercetin ameliorates diabetic kidney injury by inhibiting ferroptosis via activating nrf2/ho-1 signaling pathway. Am J Chin Med 51:997–1018. https://doi.org/10.1142/S0192415X23500465

Article  CAS  PubMed  Google Scholar 

He Z, Liao W, Song Q et al (2021) Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis. Int J Mol Med 47:289–301. https://doi.org/10.3892/ijmm.2020.4770

Article  CAS  PubMed  Google Scholar 

Hindricks J, Ebert T, Bachmann A et al (2014) Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction. Clin Endocrinol (oxf) 80:918–924. https://doi.org/10.1111/cen.12380

Article  CAS  PubMed  Google Scholar 

Hirose M, Yasui T, Okada A et al (2010) Renal tubular epithelial cell injury and oxidative stress induce calcium oxalate crystal formation in mouse kidney. Int J Urol 17:83–92. https://doi.org/10.1111/j.1442-2042.2009.02410.x

Article  CAS  PubMed  Google Scholar 

Hu J, Gu W, Ma N, Fan X, Ci X (2022) Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway. Br J Pharmacol 179:3991–4009. https://doi.org/10.1111/bph.15834

Article  CAS  PubMed  Google Scholar 

Jia Z, Li W, Bian P et al (2021) Ursolic acid treats renal tubular epithelial cell damage induced by calcium oxalate monohydrate via inhibiting oxidative stress and inflammation. Bioengineered 12:5450–5461. https://doi.org/10.1080/21655979.2021.1955176

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kirkali Z, Rasooly R, Star RA, Rodgers GP (2015) Urinary stone disease: progress, status, and needs. Urology 86:651–653. https://doi.org/10.1016/j.urology.2015.07.006

Article  PubMed  Google Scholar 

Li F, Liu Z, Tang C, Cai J, Dong Z (2018) FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury. FASEB J 32:3423–3433. https://doi.org/10.1096/fj.201701316R

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zhang J, Liu H et al (2019) Curcumin ameliorates glyoxylate-induced calcium oxalate deposition and renal injuries in mice. Phytomedicine 61:152861. https://doi.org/10.1016/j.phymed.2019.152861

Article  CAS  PubMed  Google Scholar 

Li J, Cao F, Yin HL et al (2020) Ferroptosis: past, present and future. Cell Death Dis 11:88. https://doi.org/10.1038/s41419-020-2298-2

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Chang L, Ren X, Hu Y, Chen Z (2021) Modulation of rat kidney stone crystallization and the relative oxidative stress pathway by green tea polyphenol. ACS Omega 6:1725–1731. https://doi.org/10.1021/acsomega.0c05903

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Z, Zhou Z, Liu Y et al (2011) Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese. PLoS ONE 6:e18398. https://doi.org/10.1371/journal.pone.0018398

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu H, Sun X, Jia M et al (2021) Rosiglitazone suppresses renal crystal deposition by ameliorating tubular injury resulted from oxidative stress and inflammatory response via promoting the nrf2/ho-1 pathway and shifting macrophage polarization. Oxid Med Cell Longev 2021:5527137. https://doi.org/10.1155/2021/5527137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miess H, Dankworth B, Gouw AM et al (2018) The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 37:5435–5450. https://doi.org/10.1038/s41388-018-0315-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiongyue Z, Xin Y, Meng P et al (2022) Post-treatment with irisin attenuates acute kidney injury in sepsis mice through anti-ferroptosis via the sirt1/nrf2 pathway. Front Pharmacol 13:857067. https://doi.org/10.3389/fphar.2022.857067

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodgers AL (2017) Physicochemical mechanisms of stone formation. Urolithiasis 45:27–32. https://doi.org/10.1007/s00240-016-0942-1

Article  PubMed  Google Scholar 

Shao M, Yu L, Zhang F et al (2015) Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model. Am J Physiol Endocrinol Metab 309:E45-54. https://doi.org/10.1152/ajpendo.00026.2015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi YC, Lu WW, Hou YL et al (2018) Protection effect of exogenous fibroblast growth factor 21 on the kidney injury in vascular calcification rats. Chin Med J (england) 131:532–538. https://doi.org/10.4103/0366-6999.226065

Article  CAS  Google Scholar 

Singh P, Harris PC, Sas DJ, Lieske JC (2022) The genetics of kidney stone disease and nephrocalcinosis. Nat Rev Nephrol 18:224–240. https://doi.org/10.1038/s41581-021-00513-4

Article  PubMed  Google Scholar 

Tang S, Xiao X (2020) Ferroptosis and kidney diseases. Int Urol Nephrol 52:497–503. https://doi.org/10.1007/s11255-019-02335-7

Article  PubMed  Google Scholar 

Tian H, Liang Q, Shi Z, Zhao H (2023) Hyperoside ameliorates renal tubular oxidative damage and calcium oxalate deposition in rats through ampk/nrf2 signaling axis. J Renin Angiotensin Aldosterone Syst 2023:5445548. https://doi.org/10.1155/2023/5445548

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsujihata M (2008) Mechanism of calcium oxalate renal stone formation and renal tubular cell injury. Int J Urol 15:115–120. https://doi.org/10.1111/j.1442-2042.2007.01953.x

Article  CAS  PubMed  Google Scholar 

Wang X, Chen X, Zhou W et al (2022) Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways. Acta Pharm Sin B 12:708–722. https://doi.org/10.1016/j.apsb.2021.10.005

Article  CAS  PubMed  Google Scholar 

Weng HC, Lu XY, Xu YP et al (2021) Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism. Mol Med 27:147. https://doi.org/10.1186/s10020-021-00408-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Woo YC, Xu A, Wang Y, Lam KS (2013) Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. Clin Endocrinol (oxford) 78:489–496. https://doi.org/10.1111/cen.12095

Article  CAS  Google Scholar 

Wu A, Feng B, Yu J et al (2021) Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis. Redox Biol 46:102131. https://doi.org/10.1016/j.redox.2021.102131

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie J, Ye Z, Li L et al (2022) Ferrostatin-1 alleviates oxalate-induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis. Mol Med Rep. https://doi.org/10.3892/mmr.2022.12772

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Hong S, Lu Y et al (2022) CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis. PeerJ 10:e14033. https://doi.org/10.7717/peerj.14033

Article  CAS