Riggio AI, Varley KE, Welm AL. The lingering mysteries of metastatic recurrence in breast cancer. Br J Cancer. 2021;124:13–26. https://doi.org/10.1038/s41416-020-01161-4.

Article  PubMed  Google Scholar 

Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, et al. Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 2019;69:363–85.

Article  PubMed  Google Scholar 

Liang Y, Zhang H, Song X, Yang Q. Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets. In.: Elsevier; 2020, 14–27.

Serala K, Steenkamp P, Mampuru L, Prince S, Poopedi K, Mbazima V. In vitro antimetastatic activity of Momordica balsamina crude acetone extract in HT-29 human colon cancer cells. Environ Toxicol. 2021;36:2196–205.

Article  CAS  PubMed  Google Scholar 

Mrozik KM, Blaschuk OW, Cheong CM, Zannettino ACW, Vandyke K. N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer. BMC Cancer. 2018;18:1–16.

Article  Google Scholar 

Palacios-Arreola MI, Nava-Castro KE, Castro JI, García-Zepeda E, Carrero JC, Morales-Montor J. The role of chemokines in breast cancer pathology and its possible use as therapeutic targets. J Immunol Res. 2014;2014.

Choi J, Ahn SS, Lim Y, Lee YH, Shin SY. Inhibitory effect of Alisma canaliculatum ethanolic extract on NF-κB-dependent CXCR3 and CXCL10 expression in TNFα-exposed MDA-MB-231 breast cancer cells. Int J Mol Sci. 2018;19:2607.

Article  PubMed  PubMed Central  Google Scholar 

Luo K-W, Yue GG-L, Ko C-H, Gao S, Lee JK-M, Li G, et al. The combined use of Camellia sinensis and metronomic zoledronate in 4T1 mouse carcinoma against tumor growth and metastasis. Oncol Rep. 2015;34:477–87.

Lee MM-L, Chan BD, Wong W-Y, Qu Z, Chan M-S, Leung T-W, et al. Anti-cancer activity of Centipeda minima extract in triple negative breast cancer via inhibition of AKT, NF-κB, and STAT3 signaling pathways. Front Oncol. 2020;10:491.

Nho KJ, Chun JM, Kim DS, Kim HK. Ampelopsis japonica ethanol extract suppresses migration and invasion in human MDA-MB-231 breast cancer cells. Mol Med Report. 2015;11:3722–8.

Article  CAS  Google Scholar 

Lai Y-J, Tai C-J, Wang C-W, Choong C-Y, Lee B-H, Shi Y-C, et al. Anti-cancer activity of Solanum nigrum (AESN) through suppression of mitochondrial function and epithelial-mesenchymal transition (EMT) in breast cancer cells. Molecules. 2016;21:553.

Article  PubMed  PubMed Central  Google Scholar 

Yang B, Wang N, Wang S, Li X, Zheng Y, Li M, et al. Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis. Biomed Pharmacother. 2019;112: 108607.

Article  CAS  PubMed  Google Scholar 

Wrighton KC, Thrash JC, Melnyk RA, Bigi JP, Byrne-Bailey KG, Remis JP, et al. Evidence for direct electron transfer by a Gram-positive bacterium isolated from a microbial fuel cell. Appl Environ Microbiol. 2011;77:7633–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park J, Jeong D, Song M, Kim B. Recent advances in anti-metastatic approaches of herbal medicines in 5 major cancers: from traditional medicine to modern drug discovery. Antioxidants (Basel). 2021;10:527. https://doi.org/10.3390/antiox10040527.

Article  CAS  PubMed  Google Scholar 

Mwine TJ, Damme VP. Why do Euphorbiaceae tick as medicinal plants? A review of Euphorbiaceae family and its medicinal features. 2011.

Ashraf A, Sarfraz RA, Rashid MA, Shahid M. Antioxidant, antimicrobial, antitumor, and cytotoxic activities of an important medicinal plant (Euphorbia royleana) from Pakistan. JFDA. 2015;23:109–15.

PubMed  Google Scholar 

Ebrahim HY, Osman SA, Haffez HR, Hassan ZA. In-vitro screening of some plant extracts for their potential anticancer activity. Afr J Tradit Complement Altern Med. 2020;17:1–8.

Article  CAS  Google Scholar 

Gull S, Farooq K, Tayyeb A, Arshad MI, Shahzad N. Ethanolic extracts of Pakistani euphorbiaceous plants induce apoptosis in breast cancer cells through induction of DNA damage and caspase-dependent pathway. Gene. 2022;824: 146401.

Article  CAS  PubMed  Google Scholar 

Aftab S, Khalid Z, Shakoori AR. Repression of Cell-to-Matrix Adhesion by Metformin Chloride Supports Its Anti-Metastatic Potential in an In Vitro Study on Metastatic and Non-Metastatic Cancer Cells. Critical Reviews™ in Eukaryotic Gene Expression. 2022;32.

Maskey N, Li D, Xu H, Song H, Wu C, Hua K, et al. MicroRNA-340 inhibits invasion and metastasis by downregulating ROCK1 in breast cancer cells. Oncol Lett. 2017;14:2261–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naz H, Gull S, Bashir Q, Rashid N, Shahzad N. Thermococcus kodakarensis-derived L-asparaginase: a candidate for the treatment of glioblastoma. Biologia. 2021;76:1305–14.

Article  CAS  Google Scholar 

Perveen S, Ashfaq H, Ambreen S, Ashfaq I, Kanwal Z, Tayyeb A. Methanolic extract of Citrullus colocynthis suppresses growth and proliferation of breast cancer cells through regulation of cell cycle. Saudi J Biol Sci. 2021;28:879–86.

Article  CAS  PubMed  Google Scholar 

Srinivasan A, Thangavel C, Liu Y, Shoyele S, Den RB, Selvakumar P, et al. Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer. Mol Carcinog. 2016;55:743–56.

Article  CAS  PubMed  Google Scholar 

Toulza F, Eliaou JF, Pinet V. Breast tumor cell soluble factors induce monocytes to produce angiogenic but not angiostatic CXC chemokines. Int J Cancer. 2005;115:429–36.

Article  CAS  PubMed  Google Scholar 

SenGupta S, Hein LE, Xu Y, Zhang J, Konwerski JR, Li Y, et al. Triple-negative breast cancer cells recruit neutrophils by secreting TGF-β and CXCR2 ligands. Front Immunol. 2021;12: 659996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ling G-Q, Chen D-B, Wang B-Q, Zhang L-S. Expression of the pluripotency markers Oct3/4, Nanog and Sox2 in human breast cancer cell lines. Oncol Lett. 2012;4:1264–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rashed K. Beta-Sitosterol Medicinal Properties: A Review Article. Int J Sci Inventions Today, IJSIT, 2020, 9 (4). 2020:208–12.

Chen W, Zhou S, Mao L, Zhang H, Sun D, Zhang J, et al. Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasis. Tumor Biol. 2016;37:10011–9.

Article  CAS  Google Scholar 

Morini M, Mottolese M, Ferrari N, Ghiorzo F, Buglioni S, Mortarini R, et al. The α3β1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (mmp-9) activity. Int J Cancer. 2000;87:336–42.

Article  CAS  PubMed  Google Scholar 

Al-Zharani M, Nasr FA, Abutaha N, Alqahtani AS, Noman OM, Mubarak M, et al. Apoptotic induction and anti-migratory effects of Rhazya stricta fruit extracts on a human breast cancer cell line. Molecules. 2019;24:3968.

Article  PubMed  PubMed Central  Google Scholar 

Lee HS, Na MH, Kim WK. α-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells. Nutr Res. 2010;30:403–9.

Article  CAS  PubMed  Google Scholar 

Gallardo M, Calaf GM. Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines. Int J Oncol. 2016;49:1019–27.

Article  CAS  PubMed  Google Scholar 

Balkwill F. Cancer and the chemokine network. Nat Rev Cancer. 2004;4:540–50.

Article  CAS  PubMed  Google Scholar 

Chen E, Qin X, Peng K, Xu X, Li W, Cheng X, et al. Identification of potential therapeutic targets among CXC chemokines in breast tumor microenvironment using integrative bioinformatics analysis. Cell Physiol Biochem. 2018;45:1731–46.

Article  CAS  PubMed  Google Scholar 

Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Höhneke C, et al. Curcumin downregulates the inflammatory cytokines CXCL1 and-2 in breast cancer cells via NFκB. Carcinogenesis. 2008;29:779–89.

Article  CAS  PubMed  Google Scholar 

Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, et al. Genes that mediate breast cancer metastasis to lung. Nature. 2005;436:518–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu M, Xu X, Lu H, Lu Z, Xu B, Tan C, et al. Evaluation of anti-tumor and chemoresistance-lowering effects of pectolinarigenin from Cirsium japonicum Fisch ex DC in breast cancer. Trop J Pharm Res. 2016;15:547–53.

Article  CAS  Google Scholar 

Jeter CR, Badeaux M, Choy G, Chandra D, Patrawala L, Liu C, et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem cells. 2009;27:993–1005.

Article  CAS  PubMed  Google Scholar 

Alessandra-Perini J, Perini JA, Rodrigues-Baptista KC, de Moura RS, Junior AP, Dos Santos TA, et al. Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer. BMC Complement Altern Med. 2018;18:1–11.

Article  Google Scholar 

Yousefnia S, Naseri D, Seyed Forootan F, Tabatabaeian M, Moattar F, Ghafghazi T, et al. Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells. Clin Transl Oncol. 2020;22:1619–34.

Article  CAS  PubMed  Google Scholar 

Liu Y, Li C-L, Xu Q-Q, Cheng D, Liu K-D, Sun Z-Q. Quercetin inhibits invasion and angiogenesis of esophageal cancer cells. Pathol Res Pract. 2021;222: 153455.

Article  CAS  PubMed  Google Scholar 

Salama YA, El-Karef A, El Gayyar AM, Abdel-Rahman N. Beyond its antioxidant properties: Quercetin targets multiple signalling pathways in hepatocellular carcinoma in rats. Life Sci. 2019;236: 116933.

Article  CAS  PubMed  Google Scholar