Associations of the Serum KL-6 with Severity and Prognosis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Song Q, Lin L, Zhou A et al (2023) The effects of different inhalation therapies on less symptomatic chronic obstructive pulmonary disease patients in a Chinese population: a real-world study. Ann Med 55(1):1317–1324. https://doi.org/10.1080/07853890.2023.2192519

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Xu J, Yang L et al (2018) Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet 391(10131):1706–1717. https://doi.org/10.1016/S0140-6736(18)30841-9

Article  PubMed  Google Scholar 

Zhou M, Wang H, Zeng X et al (2019) Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 394(10204):1145–1158. https://doi.org/10.1016/S0140-6736(19)30427-1

Article  PubMed  PubMed Central  Google Scholar 

Lou P, Zhu Y, Chen P et al (2012) Vulnerability, beliefs, treatments and economic burden of chronic obstructive pulmonary disease in rural areas in China: a cross-sectional study. BMC Public Health. https://doi.org/10.1186/1471-2458-12-287

Article  PubMed  PubMed Central  Google Scholar 

Boers E, Barrett M, Su JG et al (2023) Global burden of chronic obstructive pulmonary disease through 2050. JAMA Netw Open 6(12):e2346598. https://doi.org/10.1001/jamanetworkopen.2023.46598

Article  PubMed  PubMed Central  Google Scholar 

Crapo RO (1994) Pulmonary-function testing. N Engl J Med 331(1):25–30. https://doi.org/10.1056/NEJM199407073310107

Article  CAS  PubMed  Google Scholar 

Xiao C, Cheng S, Li R et al (2021) Isoforskolin alleviates AECOPD by improving pulmonary function and attenuating inflammation which involves downregulation of Th17/IL-17A and NF-κB/NLRP3. Front Pharmacol. https://doi.org/10.3389/fphar.2021.721273

Article  PubMed  PubMed Central  Google Scholar 

Weber B, Sturm R, Henrich D et al (2023) Diagnostic and prognostic potential of exosomal cytokines IL-6 and IL-10 in polytrauma patients. Int J Mol Sci 24(14):11830. https://doi.org/10.3390/ijms241411830

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vitacca M, Malovini A, Paneroni M et al (2024) Predicting response to in-hospital pulmonary rehabilitation in individuals recovering from exacerbations of chronic obstructive pulmonary disease. Arch Bronconeumol 60(3):153–160. https://doi.org/10.1016/j.arbres.2024.01.001

Article  PubMed  Google Scholar 

Lee HW, Lee JK, Hwang YI et al (2024) Spirometric interpretation and clinical relevance according to different reference equations. J Korean Med Sci. https://doi.org/10.3346/jkms.2024.39.e20

Article  PubMed  PubMed Central  Google Scholar 

Chung C, Lee JW, Lee SW et al (2024) Clinical efficacy of mobile app-based, self-directed pulmonary rehabilitation for patients with chronic obstructive pulmonary disease: systematic review and meta-analysis. JMIR Mhealth Uhealth 12:e41753. https://doi.org/10.2196/41753

Article  PubMed  PubMed Central  Google Scholar 

Ishikawa N, Hattori N, Yokoyama A et al (2012) Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases. Respir Investig 50(1):3–13. https://doi.org/10.1016/j.resinv.2012.02.001

Article  PubMed  Google Scholar 

Guan X, Zhao B, Guan X et al (2023) A benzochalcone derivative synchronously induces apoptosis and ferroptosis in pancreatic cancer cells. PeerJ. https://doi.org/10.7717/peerj.16291

Article  PubMed  PubMed Central  Google Scholar 

Endo S, Nishimura N, Kawano Y et al (2018) MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells. Biochem Biophys Res Commun 507(1–4):246–252. https://doi.org/10.1016/j.bbrc.2018.11.016

Article  CAS  PubMed  Google Scholar 

Park HK, Yoon CS, Na YO et al (2023) Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer. Sci Rep. https://doi.org/10.1038/s41598-023-45170-8

Article  PubMed  PubMed Central  Google Scholar 

Fields A, Potel KN, Cabuhal R et al (2023) Mediators of systemic sclerosis-associated interstitial lung disease (SSc-ILD): systematic review and meta-analyses. Thorax 78(8):799–807. https://doi.org/10.1136/thorax-2022-219226

Article  PubMed  Google Scholar 

Wang Y, Chen S, Zheng S et al (2021) The role of lung ultrasound B-lines and serum KL-6 in the screening and follow-up of rheumatoid arthritis patients for an identification of interstitial lung disease: review of the literature, proposal for a preliminary algorithm, and clinical application to cases. Arthritis Res Ther. https://doi.org/10.1186/s13075-021-02586-9

Article  PubMed  PubMed Central  Google Scholar 

Sokai A, Tanizawa K, Handa T et al (2017) Importance of serial changes in biomarkers in idiopathic pulmonary fibrosis. ERJ Open Res 3(3):00019–02016. https://doi.org/10.1183/23120541.00019-2016

Article  PubMed  PubMed Central  Google Scholar 

Bessa V, Bonella F, Ohshimo S et al (2019) Changes in serum KL-6 levels are associated with the development of chronic lung allograft dysfunction in lung transplant recipients. Transpl Immunol 52:40–44. https://doi.org/10.1016/j.trim.2018.10.006

Article  CAS  PubMed  Google Scholar 

d’Alessandro M, Cameli P, Refini RM et al (2020) Serum KL-6 concentrations as a novel biomarker of severe COVID-19. J Med Virol 92(10):2216–2220. https://doi.org/10.1002/jmv.26087

Article  CAS  PubMed  PubMed Central  Google Scholar 

d’Alessandro M, Bergantini L, Cameli P et al (2021) Serum concentrations of KL-6 in patients with IPF and lung cancer and serial measurements of KL-6 in IPF patients treated with antifibrotic therapy. Cancers (Basel) 13(4):689. https://doi.org/10.3390/cancers13040689

Article  CAS  PubMed  Google Scholar 

Cheng W, Zhou A, Zeng Y et al (2023) Prediction of hospitalization and mortality in patients with chronic obstructive pulmonary disease with the new global initiative for chronic obstructive lung disease 2023 group classification: a prospective cohort and a retrospective analysis. Int J Chron Obstruct Pulmon Dis 18:2341–2352. https://doi.org/10.2147/COPD.S429104

Article  PubMed  PubMed Central  Google Scholar 

Agustí A, Celli BR, Criner GJ et al (2023) Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Am J Respir Crit Care Med 207(7):819–837. https://doi.org/10.1164/rccm.202301-0106PP

Article  PubMed  PubMed Central  Google Scholar 

Zheng L, Fei J, Feng CM et al (2021) Serum 8-iso-PGF2α predicts the severity and prognosis in patients with community-acquired pneumonia: a retrospective cohort study. Front Med (Lausanne). https://doi.org/10.3389/fmed.2021.633442

Article  PubMed  Google Scholar 

Fei J, Fu L, Cao W et al (2019) Low vitamin D status is associated with epithelial-mesenchymal transition in patients with chronic obstructive pulmonary disease. J Immunol 203(6):1428–1435. https://doi.org/10.4049/jimmunol.1900229

Article  CAS  PubMed  Google Scholar 

Xu Z, Wang XM, Cao P et al (2022) Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study. Int J Med Sci 19(1):74–81. https://doi.org/10.7150/ijms.67028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng CM, Cheng JY, Xu Z et al (2021) Associations of serum resistin with the severity and prognosis in patients with community-acquired pneumonia. Front Immunol. https://doi.org/10.3389/fimmu.2021.703515

Article  PubMed  PubMed Central  Google Scholar 

Fu L, Chen YH, Bo QL et al (2019) Lipopolysaccharide downregulates 11β-hydroxysteroid dehydrogenase 2 expression through inhibiting peroxisome proliferator-activated receptor-γ in placental trophoblasts. J Immunol 203(5):1198–1207. https://doi.org/10.4049/jimmunol.1900132

Article  CAS  PubMed  Google Scholar 

Fu L, Zhao H, Xiang Y et al (2021) Reactive oxygen species-evoked endoplasmic reticulum stress mediates 1-nitropyrene-induced epithelial-mesenchymal transition and pulmonary fibrosis. Environ Pollut. https://doi.org/10.1016/j.envpol.2021.117134

Article  PubMed  Google Scholar 

Ohnishi H, Yokoyama A, Kondo K et al (2002) Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases. Am J Respir Crit Care Med 165(3):378–381. https://doi.org/10.1164/ajrccm.165.3.2107134

Article  PubMed  Google Scholar 

Oyama T, Kohno N, Yokoyama A et al (1997) Detection of interstitial pneumonitis in patients with rheumatoid arthritis by measuring circulating levels of KL-6, a human MUC1 mucin. Lung 175(6):379–385. https://doi.org/10.1007/pl00007584

Article  CAS  PubMed  Google Scholar 

Nathani N, Perkins GD, Tunnicliffe W et al (2008) Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome. Crit Care 12(1):R12. https://doi.org/10.1186/cc6785

Article  PubMed  PubMed Central  Google Scholar 

Ishikawa N, Hattori N, Kohno N et al (2015) Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls. Int J Chron Obstruct Pulmon Dis. https://doi.org/10.2147/COPD.S74557

Article 

留言 (0)

沒有登入
gif