Obesity pharmacotherapy in older adults: a narrative review of evidence

NHS. Improving care for older people. 2023. https://www.england.nhs.uk/ourwork/clinical-policy/older-people/improving-care-for-older-people/.

Arora S. Aging and non-communicable disease. In: Arora S, editor. The transitions of aging. Cham: Springer International Publishing; 2015. pp. 1–23.

Al Snih S, Ottenbacher KJ, Markides KS, Kuo YF, Eschbach K, Goodwin JS. The effect of obesity on disability vs mortality in older Americans. Arch Intern Med. 2007;167:774–80.

Article  PubMed  Google Scholar 

Colin RS, Julia H-C, Aziz S. Trends in the epidemiology of smoking recorded in UK general practice. Br J Gen Pract. 2010;60:e121–7.

Article  Google Scholar 

Peralta M, Ramos M, Lipert A, Martins J, Marques A. Prevalence and trends of overweight and obesity in older adults from 10 European countries from 2005 to 2013. Scand J Public Health. 2018;46:522–9.

Article  PubMed  Google Scholar 

Dorner TE, Rieder A. Obesity paradox in elderly patients with cardiovascular diseases. Int J Cardiol. 2012;155:56–65.

Article  PubMed  Google Scholar 

Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309:71–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sumithran P, Proietto J. The defence of body weight: a physiological basis for weight regain after weight loss. Clin Sci. 2013;124:231–41.

Article  Google Scholar 

Münzberg H, Laque A, Yu S, Rezai-Zadeh K, Berthoud HR. Appetite and body weight regulation after bariatric surgery. Obes Rev. 2015;16:77–90.

Article  PubMed  PubMed Central  Google Scholar 

Chakhtoura M, Haber R, Ghezzawi M, Rhayem C, Tcheroyan R, Mantzoros CS. Pharmacotherapy of obesity: an update on the available medications and drugs under investigation. eClinicalMedicine. 2023;58:101882.

Article  PubMed  PubMed Central  Google Scholar 

Houston DK, Ding J, Nicklas BJ, Harris TB, Lee JS, Nevitt MC, et al. Overweight and obesity over the adult life course and incident mobility limitation in older adults: the Health, Aging and Body Composition Study. Am J Epidemiol. 2009;169:927–36.

Article  PubMed  PubMed Central  Google Scholar 

Waters DL, Baumgartner RN. Sarcopenia and obesity. Clin Geriatr Med. 2011;27:401–21.

Article  PubMed  Google Scholar 

Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378:804–14.

Article  PubMed  Google Scholar 

Caleyachetty R, Barber TM, Mohammed NI, Cappuccio FP, Hardy R, Mathur R, et al. Ethnicity-specific BMI cutoffs for obesity based on type 2 diabetes risk in England: a population-based cohort study. Lancet Diabetes Endocrinol. 2021;9:419–26.

Article  PubMed  PubMed Central  Google Scholar 

Rankinen T, Kim SY, Pérusse L, Després JP, Bouchard C. The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis. Int J Obes Relat Metab Disord. 1999;23:801–9.

Article  CAS  PubMed  Google Scholar 

Winter JE, MacInnis RJ, Wattanapenpaiboon N, Nowson CA. BMI and all-cause mortality in older adults: a meta-analysis. Am J Clin Nutr. 2014;99:875–90.

Article  CAS  PubMed  Google Scholar 

DeCaria JE, Sharp C, Petrella RJ. Scoping review report: obesity in older adults. Int J Obes. 2012;36:1141–50.

Article  CAS  Google Scholar 

Luo J, Hodge A, Hendryx M, Byles JE. Age of obesity onset, cumulative obesity exposure over early adulthood and risk of type 2 diabetes. Diabetologia. 2020;63:519–27.

Article  CAS  PubMed  Google Scholar 

Tanamas SK, Wong E, Backholer K, Abdullah A, Wolfe R, Barendregt J, et al. Age of onset of obesity and risk of type 2 diabetes. Aust N Z J Public Health. 2016;40:579–81.

Article  PubMed  Google Scholar 

Wrzosek M, Wiśniewska K, Sawicka A, Tałałaj M, Nowicka G. Early onset of obesity and adult onset of obesity as factors affecting patient characteristics prior to bariatric surgery. Obes Surg. 2018;28:3902–9.

Article  PubMed  PubMed Central  Google Scholar 

Brochu M, Tchernof A, Dionne IJ, Sites CK, Eltabbakh GH, Sims EA, et al. What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab. 2001;86:1020–5.

CAS  PubMed  Google Scholar 

Vincent HK, Vincent KR, Lamb KM. Obesity and mobility disability in the older adult. Obes Rev. 2010;11:568–79.

Article  CAS  PubMed  Google Scholar 

McCarthy LH, Bigal ME, Katz M, Derby C, Lipton RB. Chronic pain and obesity in elderly people: results from the Einstein aging study. J Am Geriatr Soc. 2009;57:115–9.

Article  PubMed  Google Scholar 

Beas AO, Gordon PB, Prentiss CL, Olsen CP, Kukurugya MA, Bennett BD, et al. Independent regulation of age associated fat accumulation and longevity. Nat Commun. 2020;11:2790.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Narayan KM, Boyle JP, Thompson TJ, Gregg EW, Williamson DF. Effect of BMI on lifetime risk for diabetes in the U.S. Diabetes Care. 2007;30:1562–6.

Article  CAS  PubMed  Google Scholar 

Ahlqvist E, Storm P, Käräjämäki A, Martinell M, Dorkhan M, Carlsson A, et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 2018;6:361–9.

Article  PubMed  Google Scholar 

Dey DK, Lissner L. Obesity in 70-year-old subjects as a risk factor for 15-year coronary heart disease incidence. Obes Res. 2003;11:817–27.

Article  PubMed  Google Scholar 

Visscher TL, Seidell JC, Molarius A, van der Kuip D, Hofman A, Witteman JC. A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord. 2001;25:1730–5.

Article  CAS  PubMed  Google Scholar 

Pedditizi E, Peters R, Beckett N. The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies. Age Ageing. 2016;45:14–21.

Article  Google Scholar 

Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev. 2011;12:e426–37.

Article  CAS  PubMed  Google Scholar 

van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000;152:514–27.

Article  PubMed  Google Scholar 

Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D, et al. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ. 2007;335:1134.

Article  PubMed  PubMed Central  Google Scholar 

Wolk A, Gridley G, Svensson M, Nyrén O, McLaughlin JK, Fraumeni JF, et al. A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control. 2001;12:13–21.

Article  CAS  PubMed  Google Scholar 

Bonnefoy M, Gilbert T. Body composition and comorbidity in the elderly. Geriatr Psychol Neuropsychiatr Vieil. 2015;13:29–36.

PubMed  Google Scholar 

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16–31.

Article  PubMed  Google Scholar 

Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005;19:1–22.

Article  Google Scholar 

Kumar V, Selby A, Rankin D, Patel R, Atherton P, Hildebrandt W, et al. Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol. 2009;587:211–7.

Article  CAS  PubMed  Google Scholar 

Kalish VB. Obesity in older adults. Prim Care Clin Off Pract. 2016;43:137–44.

Article  Google Scholar 

Tzankoff SP, Norris AH. Effect of muscle mass decrease on age-related BMR changes. J Appl Physiol Respir Environ Exerc Physiol. 1977;43:1001–6.

CAS  PubMed  Google Scholar 

McLaren L. Socioeconomic status and obesity. Epidemiol Rev. 2007;29:29–48.

Article  PubMed  Google Scholar 

Antunes AC, Araújo DA, Veríssimo MT, Amaral TF. Sarcopenia and hospitalisation costs in older adults: a cross-sectional study. Nutr Diet. 2017;74:46–50.

Article  PubMed  Google Scholar 

Xu J, Wan CS, Ktoris K, Reijnierse EM, Maier AB. Sarcopenia is associated with mortality in adults: a systematic review and meta-analysis. Gerontology. 2022;68:361–76.

Article 

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