Poston L, Caleyachetty R, Cnattingius S, Corvalan C, Uauy R, Herring S, et al. Preconceptional and maternal obesity: epidemiology and health consequences. Lancet Diabetes Endocrinol. 2016;4:1025–36.

Article  PubMed  Google Scholar 

Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017-8. NCHS Data Brief 2020; 1-8.

Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VW, Eriksson JG, et al. Influence of maternal obesity on the long-term health of offspring. Lancet Diabetes Endocrinol. 2017;5:53–64.

Article  PubMed  Google Scholar 

Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017;356:j1.

Article  PubMed  PubMed Central  Google Scholar 

Persson M, Cnattingius S, Villamor E, Soderling J, Pasternak B, Stephansson O, et al. Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons. BMJ. 2017;357:j2563.

Article  PubMed  PubMed Central  Google Scholar 

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 2018;137:e67–e492.

Article  PubMed  Google Scholar 

Liu Y, Chen S, Zuhlke L, Black GC, Choy MK, Li N, et al. Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies. Int J Epidemiol. 2019;48:455–63.

Article  PubMed  PubMed Central  Google Scholar 

Jenkins KJ, Correa A, Feinstein JA, Botto L, Britt AE, Daniels SR, et al. Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. 2007;115:2995–3014.

Article  PubMed  Google Scholar 

Liu S, Joseph KS, Lisonkova S, Rouleau J, Van den Hof M, Sauve R, et al. Association between maternal chronic conditions and congenital heart defects: a population-based cohort study. Circulation. 2013;128:583–9.

Article  PubMed  Google Scholar 

Ye Z, Wang L, Yang T, Chen L, Wang T, Chen L, et al. Maternal viral infection and risk of fetal congenital heart diseases: a meta-analysis of observational studies. J Am Heart Assoc. 2019;8:e011264.

Article  PubMed  PubMed Central  Google Scholar 

Mamasoula C, Bigirumurame T, Chadwick T, Addor MC, Cavero-Carbonell C, Dias CM, et al. Maternal age and the prevalence of congenital heart defects in Europe, 1995-2015: A register-based study. Birth Defects Res. 2023;115:583–94.

Article  CAS  PubMed  Google Scholar 

Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, et al. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018;138:e653–e711.

Article  PubMed  PubMed Central  Google Scholar 

Zhu Y, Chen Y, Feng Y, Yu D, Mo X. Association between maternal body mass index and congenital heart defects in infants: A meta-analysis. Congenit Heart Dis. 2018;13:271–81.

Article  PubMed  Google Scholar 

Zheng Z, Yang T, Chen L, Wang L, Zhang S, Wang T, et al. Increased maternal Body Mass Index is associated with congenital heart defects: An updated meta-analysis of observational studies. Int. J. Cardiol. 2018;273:112–20.

Article  PubMed  Google Scholar 

Hedermann G, Hedley PL, Thagaard IN, Krebs L, Ekelund CK, Sorensen TIA, et al. Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review. PLoS ONE. 2021;16:e0252343.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogaerts A, Van den Bergh BRH, Ameye L, Witters I, Martens E, Timmerman D, et al. Interpregnancy weight change and risk for adverse perinatal outcome. Obstet Gynecol. 2013;122:999–1009.

Article  PubMed  Google Scholar 

Villamor E, Cnattingius S. Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. The Lancet. 2006;368:1164–70.

Article  Google Scholar 

Benjamin RH, Ethen MK, Canfield MA, Hua F, Mitchell LE. Association of interpregnancy change in body mass index and spina bifida. Birth Defects Res. 2019;111:1389–98.

Article  CAS  PubMed  Google Scholar 

Benjamin RH, Ethen MK, Canfield MA, Mitchell LE. Change in prepregnancy body mass index and gastroschisis. Ann Epidemiol. 2020;41:21–27.

Article  PubMed  Google Scholar 

Villamor E, Sparen P, Cnattingius S. Risk of oral clefts in relation to prepregnancy weight change and interpregnancy interval. Am J Epidemiol. 2008;167:1305–11.

Article  PubMed  Google Scholar 

Ekelund CK, Kopp TI, Tabor A, Petersen OB. The Danish Fetal Medicine database. Clin Epidemiol. 2016;8:479–83.

Article  PubMed  PubMed Central  Google Scholar 

Videbech P, Nielsen J. Electronic data processing in the Danish cytogenetic central register and EDP problems of registers in general. Clin Genet. 1979;15:137–46.

Article  CAS  PubMed  Google Scholar 

Lynge E, Sandegaard JL, Rebolj M. The danish national patient register. Scand J Public Health. 2011;39:30–33.

Article  PubMed  Google Scholar 

Knudsen LB, Olsen J. The danish medical birth registry. Dan Med Bull. 1998;45:320–3.

CAS  PubMed  Google Scholar 

Pedersen CB, Gotzsche H, Moller JO, Mortensen PB. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull. 2006;53:441–9.

PubMed  Google Scholar 

Vedel C, Hjortshoj TD, Jorgensen DS, Tabor A, Rode L, Sundberg K, et al. Prevalence of chromosomal disorders in cases with congenital heart defect: registry-based study from Denmark between 2008 and 2018. Ultrasound Obstet Gynecol. 2023;61:40–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lytzen R, Vejlstrup N, Bjerre J, Petersen OB, Leenskjold S, Dodd JK, et al. Live-Born Major Congenital Heart Disease in Denmark: Incidence, Detection Rate, and Termination of Pregnancy Rate From 1996 to 2013. JAMA Cardiology. 2018;3:829–37.

Article  PubMed  PubMed Central  Google Scholar 

Vedel C, Tabor A, Jorgensen FS, Rode L, Sundberg K, Vejlstrup N, et al. Prenatal detection rate of major congenital heart defects in Copenhagen from 2015 to 2018. Ultrasound Obstet Gynecol. 2021;58:324–5.

Article  CAS  PubMed  Google Scholar 

Greenlees R, Neville A, Addor MC, Amar E, Arriola L, Bakker M, et al. Paper 6: EUROCAT member registries: organization and activities. Birth Defects Res A Clin Mol Teratol. 2011;91:S51–S100.

Article  CAS  PubMed  Google Scholar 

Agergaard P, Hebert A, Bjerre J, Sorensen KM, Olesen C, Ostergaard JR. Children diagnosed with congenital cardiac malformations at the national university departments of pediatric cardiology: positive predictive values of data in the Danish National Patient Registry. Clin Epidemiol. 2011;3:61–66.

Article  PubMed  PubMed Central  Google Scholar 

Persson M, Razaz N, Edstedt Bonamy AK, Villamor E, Cnattingius S. Maternal overweight and obesity and risk of congenital heart defects. J Am Coll Cardiol. 2019;73:44–53.

Article  PubMed  Google Scholar 

Cai GJ, Sun XX, Zhang L, Hong Q. Association between maternal body mass index and congenital heart defects in offspring: a systematic review. Am J Obstet Gynecol. 2014;211:91–117.

Article  PubMed  Google Scholar 

Block SR, Watkins SM, Salemi JL, Rutkowski R, Tanner JP, Correia JA, et al. Maternal pre-pregnancy body mass index and risk of selected birth defects: evidence of a dose-response relationship. Paediatr Perinat Epidemiol. 2013;27:521–31.

Article  PubMed  Google Scholar 

Agopian AJ, Moulik M, Gupta-Malhotra M, Marengo LK, Mitchell LE. Descriptive epidemiology of non-syndromic complete atrioventricular canal defects. Paediatr Perinat Epidemiol. 2012;26:515–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Helle E, Priest JR. Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring. J Am Heart Assoc. 2020;9:e011541.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Best KE, Tennant PW, Bell R, Rankin J. Impact of maternal body mass index on the antenatal detection of congenital anomalies. BJOG. 2012;119:1503–11.

Article  CAS  PubMed  Google Scholar 

Uhden M, Knippel AJ, Stressig R, Hammer R, Siegmann H, Froehlich S, et al. Impact of maternal obesity and maternal overweight on the detection rate of fetal heart defects and the image quality of prenatal echocardiography. Ultraschall Med. 2011;32:E108–114.

Article  PubMed  Google Scholar 

Tinker SC, Gilboa SM, Moore CA, Waller DK, Simeone RM, Kim SY, et al. Specific birth defects in pregnancies of women with diabetes: National Birth Defects Prevention Study, 1997-2011. Am J Obstet Gynecol. 2020;222:176.e1–176.e11.

Article  PubMed  Google Scholar 

Weber KA, Mayo JA, Carmichael SL, Stevenson DK, Winn VD, Shaw GM. Occurrence of selected structural birth defects among women with preeclampsia and other hypertensive disorders. Am J Epidemiol. 2018;187:668–76.

Article