Akiskal HS. The temperamental borders of affective disorders. Acta Psychiatr Scand Suppl. 1994;379:32–7. https://doi.org/10.1111/j.1600-0447.1994.tb05815.x.

Article  CAS  PubMed  Google Scholar 

Akiskal HS. The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV. J Clin Psychopharmacol. 1996;16(2 Suppl 1):4S-14S. https://doi.org/10.1097/00004714-199604001-00002.

Article  CAS  PubMed  Google Scholar 

Akiskal HS, Akiskal K. Cyclothymic, hyperthymic, and depressive temperaments as subaffective variants of mood disorders. In: Tasman A, Riba MB, editors. Annual review of psychiatry, vol. 11. Washington: American Psychiatric Press; 1992. p. 43–62.

Google Scholar 

Akiskal KK, Akiskal HS. The theoretical underpinnings of affective temperaments: implications for evolutionary foundations of bipolar disorder and human nature. J Affect Disord. 2005;85(1–2):231–9. https://doi.org/10.1016/j.jad.2004.08.002.

Article  PubMed  Google Scholar 

Akiskal HS, Djenderedjian AM, Rosenthal RH, Khani MK. Cyclothymic disorder: validating criteria for inclusion in the bipolar affective group. Am J Psychiatry. 1977;134(11):1227–33. https://doi.org/10.1176/ajp.134.11.1227.

Article  CAS  PubMed  Google Scholar 

Akiskal HS, Hantouche EG, Bourgeois ML, Azorin JM, Sechter D, Allilaire JF, Lancrenon S, Fraud JP, Châtenet-Duchêne L. Gender, temperament, and the clinical picture in dysphoric mixed mania: findings from a French national study (EPIMAN). J Affect Disord. 1998;50(2–3):175–86. https://doi.org/10.1016/s0165-0327(98)00113-x.

Article  CAS  PubMed  Google Scholar 

Akiskal HS, Akiskal KK, Haykal RF, Manning JS, Connor PD. TEMPS-A: progress towards validation of a self-rated clinical version of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire. J Affect Disord. 2005;85(1–2):3–16. https://doi.org/10.1016/j.jad.2004.12.001.

Article  PubMed  Google Scholar 

Alarcon RD, Walter-Ryan WG, Rippetoe PA. Affective spectrum disorders. Compr Psychiatry. 1987;28(4):292–308. https://doi.org/10.1016/0010-440x(87)90065-4.

Article  CAS  PubMed  Google Scholar 

Albert U, Manchia M, Burato S, Carpiniello B, Di Salvo G, Pinna F, Rosso G, Maina G. Predominant polarity and polarity index of maintenance treatments for bipolar disorder: a validation study in a large naturalistic sample in Italy. Medicina (kaunas). 2021;57(6):598. https://doi.org/10.3390/medicina57060598.

Article  PubMed  Google Scholar 

Alphs L, Berwaerts J, Turkoz I. Limited utility of number needed to treat and the polarity index for bipolar disorder to characterize treatment response. Eur Neuropsychopharmacol. 2013;23(11):1597–9. https://doi.org/10.1016/j.euroneuro.2012.12.006.

Article  CAS  PubMed  Google Scholar 

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington: American Psychiatric Association; 1994.

Google Scholar 

American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). 2013. https://doi.org/10.1176/appi.books.9780890425596

American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed., text rev.). 2022. https://doi.org/10.1176/appi.books.9780890425787

Angst J. The course of affective disorders. II. Typology of bipolar manic-depressive illness. Arch Psychiatr Nervenkr. 1978;226(1):65–73.

Article  CAS  PubMed  Google Scholar 

Angst J. The bipolar spectrum. Br J Psychiatry. 2007;190:189–91. https://doi.org/10.1192/bjp.bp.106.030957.

Article  PubMed  Google Scholar 

Angst J, Cassano G. The mood spectrum: improving the diagnosis of bipolar disorder. Bipolar Disord. 2005;7(Suppl 4):4–12. https://doi.org/10.1111/j.1399-5618.2005.00210.x.

Article  PubMed  Google Scholar 

Angst J, Grobler C. Unipolar mania: a necessary diagnostic concept. Eur Arch Psychiatry Clin Neurosci. 2015;265(4):273–80. https://doi.org/10.1007/s00406-015-0577-1.

Article  PubMed  Google Scholar 

Argyropoulos GD, Christidi F, Karavasilis E, Bede P, Antoniou A, Velonakis G, Seimenis I, Kelekis N, Smyrnis N, Papakonstantinou O, Efstathopoulos E, Ferentinos P. Predominant polarity as a neurobiological specifier in bipolar disorder: evidence from a multimodal neuroimaging study. Prog Neuropsychopharmacol Biol Psychiatry. 2023;123: 110718. https://doi.org/10.1016/j.pnpbp.2023.110718.

Article  PubMed  Google Scholar 

Azorin JM, Adida M, Belzeaux R. Predominant polarity in bipolar disorders: Further evidence for the role of affective temperaments. J Affect Disord. 2015;182:57–63. https://doi.org/10.1016/j.jad.2015.04.037.

Article  CAS  PubMed  Google Scholar 

Baek JH, Eisner LR, Nierenberg AA. Epidemiology and course of unipolar mania: results from the national epidemiologic survey on alcohol and related conditions (NESARC). Depress Anxiety. 2014;31(9):746–55. https://doi.org/10.1002/da.22261.

Article  PubMed  Google Scholar 

Baldessarini RJ, Undurraga J, Vázquez GH, Tondo L, Salvatore P, Ha K, Khalsa HM, Lepri B, Ha TH, Chang JS, Tohen M, Vieta E. Predominant recurrence polarity among 928 adult international bipolar I disorder patients. Acta Psychiatr Scand. 2012;125(4):293–302. https://doi.org/10.1111/j.1600-0447.2011.01818.x.

Article  CAS  PubMed  Google Scholar 

Bartoli F. The diagnostic concept of unipolar mania: the missing entity of the affective spectrum. J Nerv Ment Dis. 2023;211(11):811–3. https://doi.org/10.1097/NMD.0000000000001704.

Article  PubMed  Google Scholar 

Bartoli F, Clerici M, Di Brita C, Riboldi I, Crocamo C, Carrà G. Effect of clinical response to active drugs and placebo on antipsychotics and mood stabilizers relative efficacy for bipolar depression and mania: a meta-regression analysis. J Psychopharmacol. 2018;32(4):416–22. https://doi.org/10.1177/0269881117749851.

Article  CAS  PubMed  Google Scholar 

Bartoli F, Crocamo C, Carrà G. Clinical correlates of DSM-5 mixed features in bipolar disorder: a meta-analysis. J Affect Disord. 2020;276:234–40. https://doi.org/10.1016/j.jad.2020.07.035.

Article  PubMed  Google Scholar 

Bartoli F, Nasti C, Palpella D, Piacenti S, Di Lella ME, Mauro S, Prestifilippo L, Crocamo C, Carrà G. Characterizing the clinical profile of mania without major depressive episodes: a systematic review and meta-analysis of factors associated with unipolar mania. Psychol Med. 2023a;53(15):7277–86. https://doi.org/10.1017/S0033291723000831.

Article  PubMed  PubMed Central  Google Scholar 

Bartoli F, Cavaleri D, Nasti C, Palpella D, Guzzi P, Riboldi I, Crocamo C, Pappa S, Carrà G. Long-acting injectable antipsychotics for the treatment of bipolar disorder: evidence from mirror-image studies. Ther Adv Psychopharmacol. 2023b;13:20451253231163680. https://doi.org/10.1177/20451253231163682.

Article  PubMed  PubMed Central  Google Scholar 

Bartoli F, Bachi B, Callovini T, Palpella D, Piacenti S, Morreale M, Di Lella ME, Crocamo C, Carrà G, NOMIAC Investigators. Anxious distress in people with major depressive episodes: a cross-sectional analysis of clinical correlates. CNS Spectr. 2024;29(1):49–53. https://doi.org/10.1017/S1092852923002377.

Article  PubMed  Google Scholar 

Bartoli F, Bassetti C, Gazzola M, Gianfelice L, Cavaleri D, Crocamo C, Carrà G. Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: A systematic review and meta-analysis. BJPsych Open. 2024.

Benazzi F. Bipolar II disorder: epidemiology, diagnosis and management. CNS Drugs. 2007;21(9):727–40. https://doi.org/10.2165/00023210-200721090-00003.

Article  CAS  PubMed  Google Scholar 

Brancati GE, Nunes A, Scott K, O’Donovan C, Cervantes P, Grof P, Alda M. Differential characteristics of bipolar I and II disorders: a retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment. Int J Bipolar Disord. 2023;11(1):25. https://doi.org/10.1186/s40345-023-00304-9.

Article  PubMed  PubMed Central  Google Scholar 

Carvalho AF, Quevedo J, McIntyre RS, Soeiro-de-Souza MG, Fountoulakis KN, Berk M, Hyphantis TN, Vieta E. Treatment implications of predominant polarity and the polarity index: a comprehensive review. Int J Neuropsychopharmacol. 2014;18(2): pyu079. https://doi.org/10.1093/ijnp/pyu079.

Article  PubMed  Google Scholar 

Carvalho AF, McIntyre RS, Dimelis D, Gonda X, Berk M, Nunes-Neto PR, Cha DS, Hyphantis TN, Angst J, Fountoulakis KN. Predominant polarity as a course specifier for bipolar disorder: a systematic review. J Affect Disord. 2014;163:56–64. https://doi.org/10.1016/j.jad.2014.03.035.

Article  PubMed  Google Scholar 

Clemente AS, Diniz BS, Nicolato R, Kapczinski FP, Soares JC, Firmo JO, Castro-Costa É. Bipolar disorder prevalence: a systematic review and meta-analysis of the literature. Braz J Psychiatry. 2015;37(2):155–61. https://doi.org/10.1590/1516-4446-2012-1693.

Article  PubMed  Google Scholar 

Colom F, Vieta E, Daban C, Pacchiarotti I, Sánchez-Moreno J. Clinical and therapeutic implications of predominant polarity in bipolar disorder. J Affect Disord. 2006;93(1–3):13–7. https://doi.org/10.1016/j.jad.2006.01.032.

Article  CAS  PubMed  Google Scholar 

Colom F, Vieta E, Suppes T. Predominant polarity in bipolar disorders: refining or redefining diagnosis? Acta Psychiatr Scand. 2015;132(5):324–6. https://doi.org/10.1111/acps.12503.

Article  CAS  PubMed  Google Scholar 

Dell’Osso B, Holtzman JN, Goffin KC, Portillo N, Hooshmand F, Miller S, Dore J, Wang PW, Hill SJ, Ketter TA. American tertiary clinic-referred bipolar II disorder compared to bipolar I disorder: more severe in multiple ways, but less severe in a few other ways. J Affect Disord. 2015;188:257–62. https://doi.org/10.1016/j.jad.2015.09.001.

Article  PubMed  Google Scholar 

Ferrari AJ, Somerville AJ, Baxter AJ, Norman R, Patten SB, Vos T, Whiteford HA. Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature. Psychol Med. 2013;43(3):471–81. https://doi.org/10.1017/S0033291712001511.

Article  CAS  PubMed