Cremers S, Drake MT, Ebetino FH, Bilezikian JP, Russell RGG (2019) Pharmacology of bisphosphonates. Br J Clin Pharmacol 85:1052–1062

Article  PubMed  PubMed Central  Google Scholar 

Drake MT, Clarke BL, Khosla S (2008) Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc 83:1032–1045

Article  CAS  PubMed  Google Scholar 

Kates SL, Ackert-Bicknell CL (2016) How do bisphosphonates affect fracture healing? Injury 47:S65–S68. https://doi.org/10.1016/S0020-1383(16)30015-8. Elsevier Ltd

Article  PubMed  PubMed Central  Google Scholar 

Ribeiro V, Garcia M, Oliveira R, Gomes PS, Colaço B, Fernandes MH (2014) Bisphosphonates induce the osteogenic gene expression in co-cultured human endothelial and mesenchymal stem cells. J Cell Mol Med 18:27–37

Article  CAS  PubMed  Google Scholar 

Kuźnik A, Październiok-Holewa A, Jewula P, Kuźnik N (2020) Bisphosphonates-much more than only drugs for bone diseases. Eur J Pharmacol 866:172773. https://doi.org/10.1016/j.ejphar.2019.172773. Epub 2019 Nov 6. PMID: 31705903

Article  CAS  PubMed  Google Scholar 

de Campos WG, Araújo R, Júnior CAL, de Sousa Gomes P (2023) Alendronate induces skeletal alterations in the chicken embryonic development model. Toxicol Appl Pharmacol 476:116673. https://doi.org/10.1016/j.taap.2023.116673. Elsevier Inc.

Article  CAS  PubMed  Google Scholar 

Clemente L, Boeldt DS, Grummer MA, Morita M, Morgan TK, Wiepz GJ et al (2020) Adenoviral transduction of EGFR into pregnancy-adapted uterine artery endothelial cells remaps growth factor induction of endothelial dysfunction. Mol Cell Endocrinol 499:110590. https://doi.org/10.1016/j.mce.2019.110590. Elsevier

Article  CAS  PubMed  Google Scholar 

Patlas N, Golomb G, Yaffe P, Pinto T, Breuer E, Ornoy A (1999) Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. Teratology United States 60:68–73

CAS  Google Scholar 

Graepel P, Bentley P, Fritz H, Miyamoto M, Slater SR (1992) Reproduction toxicity studies with pamidronate. Arzneimittelforschung Germany 42:654–667

CAS  Google Scholar 

Minsker DH, Manson JM, Peter CP (1993) Effects of the bisphosphonate, alendronate, on parturition in the rat. Toxicol Appl Pharmacol United States 121:217–223

Article  CAS  Google Scholar 

Levy S, Fayez I, Taguchi N, Han JY, Aiello J, Matsui D et al (2009) Pregnancy outcome following in utero exposure to bisphosphonates. Bone 44:428–430. https://doi.org/10.1016/j.bone.2008.11.001. Elsevier Inc.

Article  CAS  PubMed  Google Scholar 

Ornoy A, Wajnberg R, Diav-Citrin O (2006) The outcome of pregnancy following pre-pregnancy or early pregnancy alendronate treatment. Reprod Toxicol United States 22:578–579

Article  CAS  Google Scholar 

Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, Stephenson M, Aromataris E (2020) Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evid Synth 18(10):2127–2133

PubMed  Google Scholar 

Mastaglia SR, Watman NP, Oliveri B (2010) Intravenous bisphosphonate treatment and pregnancy: its effects on mother and infant bone health. Osteoporos Int England 21:1959–1962

Article  CAS  Google Scholar 

Koren R, Neeman O, Koren S, Benbassat CA (2018) Humoral hypercalcemia of pregnancy treated with bisphosphonates. Arch Endocrinol Metab Brazil 62:125–128

Article  Google Scholar 

Sokal A, Elefant E, Leturcq T, Beghin D, Mariette X, Seror R (2019) Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study. Osteoporos Int Osteoporosis International 30:221–229

Article  CAS  PubMed  Google Scholar 

Chan B, Zacharin M (2006) Maternal and infant outcome after pamidronate treatment of polyostotic fibrous dysplasia and osteogenesis imperfecta before conception: a report of four cases. J Clin Endocrinol Metab 91:2017–2020

Article  CAS  PubMed  Google Scholar 

Munns CFJ, Rauch F, Ward L, Glorieux FH (2004) Maternal and fetal outcome after long-term pamidronate treatment before conception: a report of two cases. J Bone Miner Res 19:1742–1745

Article  PubMed  Google Scholar 

Losada I, Sartori L, Di Gianantonio E, Zen M, Clementi M, Doria A (2010) Bisphosphonates in patients with autoimmune rheumatic diseases: can they be used in women of childbearing age? Autoimmun Rev Netherlands 9:547–552

Article  CAS  Google Scholar 

Vujasinovic-Stupar N, Pejnovic N, Markovic L, Zlatanovic M (2012) Pregnancy-associated spinal osteoporosis treated with bisphosphonates: long-term follow-up of maternal and infants outcome. Rheumatol Int Germany 32:819–823

Article  Google Scholar 

Chen CP, Lin SP, Su YN, Huang JP, Chern SR, Su JW, Wang W (2012) Uncomplicated vaginal delivery in two consecutive pregnancies carried to term in a woman with osteogenesis imperfecta type I and bisphosphonate treatment before conception. Taiwan J Obstet Gynecol 51(2):305–307. https://doi.org/10.1016/j.tjog.2012.04.029. PMID: 22795118

Article  PubMed  Google Scholar 

Barrera BA, Wilton L, Harris S, Shakir SAW (2005) Prescription-event monitoring study on 13,164 patients prescribed risedronate in primary care in England. Osteoporos Int 16:1989–1998

Article  PubMed  Google Scholar 

Athimulam S, Chan P, Baker M, Nauta M, Yoong W (2007) The effect of pregnancy on pre-existing osteopenia: a case report. Arch Gynecol Obstet Germany 276:175–177

Article  Google Scholar 

Biswas PN, Wilton LV, Shakir SAW (2003) Pharmacovigilance study of alendronate in England. Osteoporos Int England 14:507–514

Article  CAS  Google Scholar 

Machairiotis N, Ntali G, Kouroutou P, Michala L (2019) Clinical evidence of the effect of bisphosphonates on pregnancy and the infant. Horm Mol Biol Clin Investig 40(2). https://doi.org/10.1515/hmbci-2019-0021. PMID: 31539355

Green SB, Papas AL (2014) Effects of maternal bisphosphonate use on fetal and neonatal outcomes. Am J Heal Pharm 71:2029–2036

Article  CAS  Google Scholar 

Leipe J, Holle JU, Weseloh C, Pfeil A, Krüger K (2021) German society of rheumatology recommendations for the management of glucocorticoid-induced osteoporosis. German version. Z Rheumatol Germany 80:670–87

Article  CAS  Google Scholar 

Cohen A, Fleischer J, Freeby MJ, McMahon DJ, Irani D, Shane E (2009) Clinical characteristics and medication use among premenopausal women with osteoporosis and low BMD: The experience of an osteoporosis referral center. J Women’s Heal 18:79–84

Article  Google Scholar 

Stathopoulos IP, Liakou CG, Katsalira A, Trovas G, Lyritis GG, Papaioannou NA, Tournis S (2011) The use of bisphosphonates in women prior to or during pregnancy and lactation. Hormones (Athens) 10(4):280–291. https://doi.org/10.14310/horm.2002.1319. PMID: 22281884

Article  PubMed  Google Scholar 

Griebel CP, Halvorsen J, Golemon TB, Day AA (2005) Management of spontaneous abortion. Am Fam Physician 72:1243–1250

PubMed  Google Scholar 

Cohain JS, Buxbaum RE, Mankuta D (2017) Spontaneous first trimester miscarriage rates per woman among parous women with 1 or more pregnancies of 24 weeks or more. BMC Pregnancy Childbirth 17:1–7

Article  Google Scholar 

Moradinazar M, Najafi F, Nazar ZM, Hamzeh B, Pasdar Y, Shakiba E (2020) Lifetime prevalence of abortion and risk factors in women: Evidence from a cohort study. J Pregnancy 2020:4871494. https://doi.org/10.1155/2020/4871494. PMID: 32395342; PMCID: PMC7201453

Article  PubMed  PubMed Central  Google Scholar 

Corsello G, Giuffrè M (2012) Congenital malformations J Matern Neonatal Med 25:25–29

Google Scholar 

Cho WI, Yu HW, Chung HR, Shin CH, Yang SW, Choi CW et al (2015) Clinical and laboratory characteristics of neonatal hypocalcemia. Ann Pediatr Endocrinol Metab 20:86

Article  PubMed  PubMed Central  Google Scholar 

Vuralli D (2019) Clinical Approach to hypocalcemia in newborn period and infancy: Who should be treated? Int J Pediatr 2019:4318075. https://doi.org/10.1155/2019/4318075. PMID: 31320908; PMCID: PMC6607701

Article  PubMed  PubMed Central  Google Scholar 

Thomas TC, Smith JM, White PC, Adhikari S (2012) Transient neonatal hypocalcemia: presentation and outcomes. Pediatrics 129(6):e1461–e1467. https://doi.org/10.1542/peds.2011-2659. Epub 2012 May 21. PMID: 22614771

Article  PubMed  Google Scholar 

Liamis G, Milionis HJ, Elisaf M (2009) A review of drug-induced hypocalcemia. J Bone Miner Metab 27:635–642

Article  CAS  PubMed  Google Scholar 

Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P (2018) The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol 52:3–12. https://doi.org/10.1016/j.bpobgyn.2018.04.003. Elsevier Ltd

Article  PubMed  Google Scholar 

Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379:2162–2172. https://doi.org/10.1016/S0140-6736(12)60820-4. Elsevier Ltd

Article  PubMed  Google Scholar 

Negrato CA, Gomes MB (2013) Low birth weight: causes and consequences. Diabetol Metab Syndr 5:1–8

Article  Google Scholar 

Metgud CS, Naik VA, Mallapur MD (2012) Factors affecting birth weight of a newborn–a community based study in rural Karnataka, India. PLoS One 7(7):e40040. https://doi.org/10.1371/journal.pone.0040040. Epub 2012 Jul 5. PMID: 22792210; PMCID: PMC3390317

Article  CAS  PubMe