Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

Anderson SR, Roberts JM, Zhang J, Steele MR, Romero CO, Bosco A, Vetter ML. Developmental apoptosis promotes disease-related gene signature and independence from CSF1R signaling in retinal microglia. Cell Rep. 2019;27(7):2002–13. https://doi.org/10.1016/j.celrep.2019.04.062.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnett A, Crews F, Coleman L. Microglial depletion and repopulation: a new era of regenerative medicine? Neural Regen Res. 2021;16(6):1204. https://doi.org/10.4103/1673-5374.300439.

Article  PubMed  Google Scholar 

Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB, Mulinyawe SB, Bohlen CJ, Adil A, Tucker A, Weissman IL, Chang EF, Li G, Grant GA, Hayden Gephart MG, Barres BA. New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci. 2016. https://doi.org/10.1073/pnas.1525528113.

Article  PubMed  PubMed Central  Google Scholar 

Bennett RE, Bryant A, Hu M, Robbins AB, Hopp SC, Hyman BT. Partial reduction of microglia does not affect tau pathology in aged mice. J Neuroinflamm. 2018;15(1):311. https://doi.org/10.1186/s12974-018-1348-5.

Article  CAS  Google Scholar 

Cartier N, Lewis C-A, Zhang R, Rossi FM. The role of microglia in human disease: therapeutic tool or target? Acta Neuropathol. 2014;128(3):363–80. https://doi.org/10.1007/s00401-014-1330-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi I, Heaton GR, Lee Y-K, Yue Z. Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy. Sci Adv. 2022. https://doi.org/10.1126/sciadv.abn1298.

Article  PubMed  PubMed Central  Google Scholar 

Croisier E, Moran LB, Dexter DT, Pearce RKB, Graeber MB. Microglial inflammation in the parkinsonian substantia nigra: Relationship to alpha-synuclein deposition. J Neuroinflamm. 2005. https://doi.org/10.1186/1742-2094-2-14.

Article  Google Scholar 

Doorn KJ, Moors T, Drukarch B, Dj Van De Berg W, Lucassen PJ, van Dam AM. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients; 2014. http://www.actaneurocomms.org/content/2/1/90

Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Fischer DL, Stoll AC, Sortwell CE. Quality over quantity: Advantages of using alpha-synuclein preformed fibril triggered synucleinopathy to model idiopathic Parkinson’s disease. Front Neurosci. 2018;12:1–10. https://doi.org/10.3389/fnins.2018.00621.

Article  Google Scholar 

Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer LD, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, Sortwell CE. Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. J Neuroinflamm. 2018. https://doi.org/10.1186/s12974-018-1171-z.

Article  Google Scholar 

Earls RH, Menees KB, Chung J, Barber J, Gutekunst CA, Hazim MG, Lee JK. Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice. J Neuroinflamm. 2019. https://doi.org/10.1186/s12974-019-1636-8.

Article  Google Scholar 

Elmore MRP, Hohsfield LA, Kramár EA, Soreq L, Lee RJ, Pham ST, Najafi AR, Spangenberg EE, Wood MA, West BL, Green KN. Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice. Aging Cell. 2018;17(6): e12832. https://doi.org/10.1111/acel.12832.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elmore MRP, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, Kitazawa M, Matusow B, Nguyen H, West BL, Green KN. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron. 2014;82(2):380–97. https://doi.org/10.1016/j.neuron.2014.02.040.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu H, Zhao Y, Hu D, Wang S, Yu T, Zhang L. Depletion of microglia exacerbates injury and impairs function recovery after spinal cord injury in mice. Cell Death Dis. 2020;11(7):528. https://doi.org/10.1038/s41419-020-2733-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldmann T, Wieghofer P, Jordão MJC, Prutek F, Hagemeyer N, Frenzel K, Amann L, Staszewski O, Kierdorf K, Krueger M, Locatelli G, Hochgerner H, Zeiser R, Epelman S, Geissmann F, Priller J, Rossi FMV, Bechmann I, Kerschensteiner M, et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat Immunol. 2016;17(7):797–805. https://doi.org/10.1038/ni.3423.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han J, Zhu K, Zhang X-M, Harris RA. Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders. Glia. 2019;67(2):217–31. https://doi.org/10.1002/glia.23529.

Article  PubMed  Google Scholar 

Harms AS, Cao S, Rowse AL, Thome AD, Li X, Mangieri LR, Cron RQ, Shacka JJ, Raman C, Standaert DG. MHCII Is required for a-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J Neurosci. 2013;33(23):9592–600. https://doi.org/10.1523/JNEUROSCI.5610-12.2013.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harms AS, Delic V, Thome AD, Bryant N, Liu Z, Chandra S, Jurkuvenaite A, West AB. α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. Acta Neuropathol Commun. 2017;5(1):85. https://doi.org/10.1186/s40478-017-0494-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imamura K, Hishikawa N, Sawada M, Nagatsu T, Yoshida M, Hashizume Y. Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson’s disease brains. Acta Neuropathol. 2003;106(6):518–26. https://doi.org/10.1007/s00401-003-0766-2.

Article  CAS  PubMed  Google Scholar 

Karampetsou M, Ardah MT, Semitekolou M, Polissidis A, Samiotaki M, Kalomoiri M, Majbour N, Xanthou G, El-Agnaf OMA, Vekrellis K. Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice. Sci Rep. 2017;7(1):1–18. https://doi.org/10.1038/s41598-017-15813-8.

Article  CAS  Google Scholar 

Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, et al. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. Cell Rep. 2022;39(11):110961. https://doi.org/10.1016/j.celrep.2022.110961.

Article  CAS  PubMed  Google Scholar 

Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, Halliday GM, Bartus RT. Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease. Brain. 2013;136(8):2419–31. https://doi.org/10.1093/brain/awt192.

Article  PubMed  PubMed Central  Google Scholar 

Lazdon E, Stolero N, Frenkel D. Microglia and Parkinson’s disease: footprints to pathology. J Neural Transm. 2020;127(2):149–58. https://doi.org/10.1007/s00702-020-02154-6.

Article  PubMed  Google Scholar 

Leys C, Ley C, Klein O, Bernard P, Licata L. Detecting outliers: do not use standard deviation around the mean, use absolute deviation around the median. J Exp Soc Psychol. 2013;49(4):764–6. https://doi.org/10.1016/j.jesp.2013.03.013.

Article  Google Scholar 

Li Q, Shen C, Liu Z, Ma Y, Wang J, Dong H, Zhang X, Wang Z, Yu M, Ci L, Sun R, Shen R, Fei J, Huang F. Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease. Cell Prolif. 2021. https://doi.org/10.1111/cpr.13094.

Article  PubMed  PubMed Central  Google Scholar 

Luk KC, Kehm V, Carroll J, Zhang B, O’Brien P, Trojanowski JQ, Lee VMY. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science. 2012;338(6109):949–53. https://doi.org/10.1126/science.1227157.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luk KC, Kehm VM, Zhang B, O’Brien P, Trojanowski JQ, Lee VMY. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med. 2012;209(5):975–88. https://doi.org/10.1084/jem.20112457.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma SX, Seo BA, Kim D, Xiong Y, Kwon SH, Brahmachari S, Kim S, Kam TI, Nirujogi RS, Kwon SH, Dawson VL, Dawson TM, Pandey A, Na CH, Ko HS. Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in α-synuclein-based mouse models of Parkinson’s disease. J Proteome Res. 2021;20(7):3428–43. https://doi.org/10.1021/acs.jproteome.0c01002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marras C, Beck JC, Bower JH, Roberts E, Ritz B, Ross GW, Abbott RD, Savica R, van den Eeden SK, Willis AW, Tanner C. Prevalence of Parkinson’s disease across North America. NPJ Parkinson’s Dis. 2018. https://doi.org/10.1038/s41531-018-0058-0.

Article  Google Scholar 

McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains. Neurology. 1988;38(8):1285–1285. https://doi.org/10.1212/WNL.38.8.1285.

Article  CAS  PubMed  Google Scholar 

McGeer PL, Itagaki S, Mcgeer EG. Acta heuropathologica expression of the histocompatibility glycoprotein HLA-DR in neurological disease*. Acta Neuropathol. 1988;76:550–7.

Article  CAS  PubMed  Google Scholar 

Menassa DA, Gomez-Nicola D. Microglial dynamics during human brain development. Front Immunol. 2018. https://doi.org/10.3389/fimmu.2018.01014.

Article  PubMed  PubMed Central 

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