Llovet JM, Montal R, Sia D, Finn RS. Molecular therapies and precision medicine for hepatocellular carcinoma. Nat Rev Clin Oncol. 2018;15:599–616. https://doi.org/10.1038/s41571-018-0073-4.

Article  PubMed  Google Scholar 

Villanueva A. Hepatocellular carcinoma. N Engl J Med. 2019. https://doi.org/10.1056/NEJMra1713263.

Article  PubMed  Google Scholar 

Neophytou CM, Panagi M, Stylianopoulos T, Papageorgis P. The role of tumor microenvironment in cancer metastasis: molecular mechanisms and therapeutic opportunities. Cancers. 2021;13(9):2053. https://doi.org/10.3390/cancers13092053.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Le Grazie M, Biagini MR, Tarocchi M, Polvani S, Galli A. Chemotherapy for hepatocellular carcinoma: the present and the future. World J Hepatol. 2017;9(21):907. https://doi.org/10.4254/wjh.v9.i21.907.

Article  PubMed  PubMed Central  Google Scholar 

Raza A, Sood GK. Hepatocellular carcinoma review: current treatment and evidence-based medicine. World J Gastroenterol. 2014;20(15):4115–27. https://doi.org/10.3748/wjg.v20.i15.4115.

Article  PubMed  PubMed Central  Google Scholar 

Chen CP. Role of radiotherapy in the treatment of hepatocellular carcinoma. J Clin Transl Hepatol. 2019;7(2):183. https://doi.org/10.14218/JCTH.2018.00060.

Article  PubMed  PubMed Central  Google Scholar 

Liu JKH, Irvine AF, Jones RL, Samson A. Immunotherapies for hepatocellular carcinoma. Cancer Med. 2022;11(3):571–91. https://doi.org/10.1002/cam4.4468.

Article  CAS  PubMed  Google Scholar 

Xiang Y, Guo Z, Zhu P, Chen J, Huang Y. Traditional Chinese medicine as a cancer treatment: modern perspectives of ancient but advanced science. Cancer Med. 2019;8(5):1958–75. https://doi.org/10.1002/cam4.2108.

Article  PubMed  PubMed Central  Google Scholar 

Ugarte RA, Craigie JS, Critchley AT. Fucoid flora of the rocky intertidal of the Canadian Maritimes: implications for the future with rapid climate change. Seaweeds Role Glob Chang Environ. 2010. https://doi.org/10.1007/978-90-481-8569-6_5.

Article  Google Scholar 

Gull N, Arshad F, Naikoo GA. Recent advances in anticancer activity of novel plant extracts and compounds from curcuma longa in hepatocellular carcinoma. J Gastrointest Cancer. 2022. https://doi.org/10.1007/s12029-022-00809-z.

Article  PubMed  PubMed Central  Google Scholar 

Iqbal J, Abbasi BA, Ahmad R, Mahmood T, Kanwal S, Ali B, Khalil AT, Shah SA, Alam MM, Badshah H. Ursolic acid a promising candidate in the therapeutics of breast cancer: current status and future implications. Biomed Pharmacother. 2018;108:752 6. https://doi.org/10.1016/j.biopha.2018.09.096.

Article  CAS  PubMed  Google Scholar 

Agarwal G, Carcache PJB, Addo EM, Kinghorn AD. Current status and contemporary approaches to the discovery of antitumor agents from higher plants. Biotechnol Adv. 2020;38:107337. https://doi.org/10.1016/j.biotechadv.2019.01.004.

Article  CAS  PubMed  Google Scholar 

Iqbal J, Abbasi BA, Batool R, Mahmood T, Ali B, Khalil AT, Kanwal S, Shah SA, Ahmad R. Potential phytocompounds for developing breast cancer therapeutics: nature’s healing touch. Eur J Pharmacol. 2018;827:125–48. https://doi.org/10.1016/j.ejphar.2018.03.007.

Article  CAS  PubMed  Google Scholar 

Avtanski D, Poretsky L. Phyto-polyphenols as potential inhibitors of breast cancer metastasis. Mol Med. 2018;24(1):1–17. https://doi.org/10.1186/s10020-018-0032-7.

Article  CAS  Google Scholar 

Shehzad A, Qureshi M, Anwar MN, Lee YS. Multifunctional curcumin mediate multitherapeutic effects. J Food Sci. 2017;82(9):2006–15. https://doi.org/10.1111/1750-3841.13793.

Article  CAS  PubMed  Google Scholar 

Pan Z, Zhuang J, Ji C, Cai Z, Liao W, Huang Z. Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression. Oncol Lett. 2018;15(4):4821–6. https://doi.org/10.3892/ol.2018.7988.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu MX, Zhao L, Deng C, Yang LU, Wang Y, Guo T, Li L, Lin J, Zhang L. Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway. Int J Oncol. 2013;43(6):1951–9. https://doi.org/10.3892/ijo.2013.2107.

Article  CAS  PubMed  Google Scholar 

Teng CF, Yu CH, Chang HY, Hsieh WC, Wu TH, Lin JH, Wu HC, Jeng LB, Su IJ. Chemopreventive effect of phytosomal curcumin on hepatitis B virus-related hepatocellular carcinoma in a transgenic mouse model. Sci Rep. 2019;9(1):10338. https://doi.org/10.1038/s41598-019-46891-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matias D, Rijo P, Pinto RC. Phytosomes as biocompatible carriers of natural drugs. Curr Med Chem. 2017;24(6):568–89. https://doi.org/10.2174/0929867323666161028160855.

Article  CAS  PubMed  Google Scholar 

Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A. Phytosomal curcumin: a review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother. 2017;129:101 7. https://doi.org/10.1016/j.carbpol.2015.04.057.

Article  CAS  Google Scholar 

Yuan Y, Macquarrie D. Microwave assisted extraction of sulfated polysaccharides (fucoidan) from Ascophyllum nodosum and its antioxidant activity. Carbohydr Polym. 2015;129:101 7. https://doi.org/10.1016/j.carbpol.2015.04.057.

Article  CAS  PubMed  Google Scholar 

Venardou B, O’Doherty JV, Garcia-Vaquero M, Kiely C, Rajauria G, McDonnell MJ, Ryan MT, Sweeney T. Evaluation of the antibacterial and prebiotic potential of Ascophyllum nodosum and its extracts using selected bacterial members of the pig gastrointestinal microbiota. Mar Drugs. 2021;20(1):41. https://doi.org/10.3390/md20010041.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ajah HA. In vitro and in vivo studies on the antifungal activity of probiotics and seaweed extract (Ascophyllum nodosum). Int J Innov Sci Eng Technol. 2016;3(4):306–12.

Google Scholar 

Chauhan BS, Kumar R, Kumar P, Kumar P, Sinha S, Mishra SK, Tiwari KN, Critchley AT, Prithiviraj B, Srikrishna S. Neuroprotective potential of flavonoid rich Ascophyllum nodosum (FRAN) fraction from the brown seaweed on an Aβ42 induced Alzheimer’s model of Drosophila. Phytomed. 2022;95:153872. https://doi.org/10.1016/j.phymed.2021.153872.

Article  CAS  Google Scholar 

Daina A, Michielin O, Zoete V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 2019;42(W1):W32–8. https://doi.org/10.1093/nar/gkz382.

Article  CAS  Google Scholar 

Zhi-Jiang Y, Jie D, Yu-Jing C, Min-Feng Z, Ming W, Ning-Ning W, Shan W, Ai-Ping Lu, Cao D-S. TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models. J Comput Aided Mol Des. 2016;30:413–24. https://doi.org/10.1007/s10822-016-9915-2.

Article  CAS  Google Scholar 

Safran M, Dalah I, Alexander J, Rosen N, Iny Stein T, Shmoish M, Nativ N, Bahir I, Doniger T, Krug H, Sirota-Madi A. GeneCards version 3: the human gene integrator. Database. 2010. https://doi.org/10.1093/database/baq020.

Article  PubMed  PubMed Central  Google Scholar 

Piñero J, Saüch J, Sanz F, Furlong LI. The DisGeNET cytoscape app: exploring and visualizing disease genomics data. Comput Struct Biotechnol J. 2021;19(7789):2960–7. https://doi.org/10.1016/j.csbj.2021.05.015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lotia S, Montojo J, Dong Y, Bader GD, Pico AR. Cytoscape app store. Bioinformatics. 2013;29(10):1350–1. https://doi.org/10.1093/bioinformatics/btt138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge SX, Jung D, Yao R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics. 2020;36(8):2628–9. https://doi.org/10.1093/bioinformatics/btz931.

Article  CAS  PubMed  Google Scholar 

Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019. https://doi.org/10.1093/bioinformatics/btz931.

Article  PubMed  PubMed Central  Google Scholar 

Desai AG, Qazi GN, Ganju RK, El-Tamer M, Singh J, Saxena AK, Bedi YS, Taneja SC, Bhat HK. Medicinal plants and cancer chemoprevention. Curr Drug Metab. 2008;9(7):581–91. https://doi.org/10.2174/138920008785821657.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meinita MDN, Harwanto D, Tirtawijaya G, Negara BFSP, Sohn JH, Kim JS, Choi JS. Fucosterol of marine macroalgae: bioactivity, safety and toxicity on organism. Mar Drugs. 2021;19(10):545. https://doi.org/10.3390/md19100545.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang J, Lv J, Liu Z. Identification of dysfunctional biological pathways and their synergistic mechanism in hepato