Roger VL. Epidemiology of heart failure: a contemporary perspective. Circ Res. 2021;128(10):1421–34. https://doi.org/10.1161/CIRCRESAHA.121.318172.

Article  CAS  PubMed  Google Scholar 

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB, American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics–2015 update: a report from the American Heart Association. Circulation. 2015;131(4):e29-322. https://doi.org/10.1161/CIR.0000000000000152.

Article  PubMed  Google Scholar 

Ziaeian B, Fonarow GC. Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 2016;13(6):368–78. https://doi.org/10.1038/nrcardio.2016.25.

Article  PubMed  PubMed Central  Google Scholar 

Wang H, Chai K, Du M, Wang S, Cai JP, Li Y, Zeng P, Zhu W, Zhan S, Yang J. Prevalence and incidence of heart failure among urban patients in china: a national population-based analysis. Circ Heart Fail. 2021;14(10): e008406. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008406.

Article  PubMed  Google Scholar 

Omote K, Verbrugge FH, Borlaug BA. Heart failure with preserved ejection fraction: mechanisms and treatment strategies. Annu Rev Med. 2022;73:321–37. https://doi.org/10.1146/annurev-med-042220-022745.

Article  CAS  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e895–1032. https://doi.org/10.1161/CIR.0000000000001063.

Article  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW. 2022 AHA/ACC/HFSA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e876–94. https://doi.org/10.1161/CIR.0000000000001062.

Article  PubMed  Google Scholar 

Park JJ. Epidemiology, pathophysiology, diagnosis and treatment of heart failure in diabetes. Diabetes Metab J. 2021;45(2):146–57. https://doi.org/10.4093/dmj.2020.0282.

Article  PubMed  PubMed Central  Google Scholar 

Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. https://doi.org/10.1038/s41419-020-2298-2.

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Li X, Ge C, Min J, Wang F. The multifaceted role of ferroptosis in liver disease. Cell Death Differ. 2022;29(3):467–80. https://doi.org/10.1038/s41418-022-00941-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172(3):409-422.e21. https://doi.org/10.1016/j.cell.2017.11.048.

Article  CAS  PubMed  Google Scholar 

Floros KV, Cai J, Jacob S, Kurupi R, Fairchild CK, Shende M, Coon CM, Powell KM, Belvin BR, Hu B, Puchalapalli M, Ramamoorthy S, Swift K, Lewis JP, Dozmorov MG, Glod J, Koblinski JE, Boikos SA, Faber AC. MYCN-amplified neuroblastoma is addicted to iron and vulnerable to inhibition of the system Xc-/glutathione axis. Cancer Res. 2021;81(7):1896–908. https://doi.org/10.1158/0008-5472.CAN-20-1641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maiorino M, Conrad M, Ursini F. GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues. Antioxid Redox Signal. 2018;29(1):61–74. https://doi.org/10.1089/ars.2017.7115.

Article  CAS  PubMed  Google Scholar 

Cardoso BR, Hare DJ, Bush AI, Roberts BR. Glutathione peroxidase 4: a new player in neurodegeneration? Mol Psychiatry. 2017;22(3):328–35. https://doi.org/10.1038/mp.2016.196.

Article  CAS  PubMed  Google Scholar 

Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol. 2021;220(9): e202105043. https://doi.org/10.1083/jcb.202105043.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–31. https://doi.org/10.1016/j.cell.2013.12.010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, Stockwell BR. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014;3: e02523. https://doi.org/10.7554/eLife.02523.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Zhabyeyev P, Wang S, Oudit GY. Role of iron metabolism in heart failure: from iron deficiency to iron overload. Biochim Biophys Acta Mol Basis Dis. 2019;1865(7):1925–37. https://doi.org/10.1016/j.bbadis.2018.08.030.

Article  CAS  PubMed  Google Scholar 

Anand IS, Gupta P. Anemia and iron deficiency in heart failure: current concepts and emerging therapies. Circulation. 2018;138(1):80–98. https://doi.org/10.1161/CIRCULATIONAHA.118.030099.

Article  CAS  PubMed  Google Scholar 

Gujja P, Rosing DR, Tripodi DJ, Shizukuda Y. Iron overload cardiomyopathy: better understanding of an increasing disorder. J Am Coll Cardiol. 2010;56(13):1001–12. https://doi.org/10.1016/j.jacc.2010.03.083.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang X, Ardehali H, Min J, Wang F. The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. Nat Rev Cardiol. 2023;20(1):7–23. https://doi.org/10.1038/s41569-022-00735-4.

Article  PubMed  Google Scholar 

Li Q, Zhao Z, Zhou X, Yan Y, Shi L, Chen J, Fu B, Mao J. Ferroptosis: the potential target in heart failure with preserved ejection fraction. Cells. 2022;11(18):2842. https://doi.org/10.3390/cells11182842.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cerami C. Iron nutriture of the fetus, neonate, infant, and child. Ann Nutr Metab. 2017;71:8–14. https://doi.org/10.1159/000481447.

Article  CAS  PubMed  Google Scholar 

Rouault TA. The intestinal heme transporter revealed. Cell. 2005;122(5):649–51. https://doi.org/10.1016/j.cell.2005.08.027.

Article  CAS  PubMed  Google Scholar 

Conrad ME, Umbreit JN. Pathways of iron absorption. Blood Cells Mol Dis. 2002;29(3):336–55. https://doi.org/10.1006/bcmd.2002.0564.

Article  CAS  PubMed  Google Scholar 

Muckenthaler MU, Rivella S, Hentze MW, Galy B. A red carpet for iron metabolism. Cell. 2017;168(3):344–61. https://doi.org/10.1016/j.cell.2016.12.034.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paterek A, Mackiewicz U, Mączewski M. Iron and the heart: a paradigm shift from systemic to cardiomyocyte abnormalities. J Cell Physiol. 2019;234(12):21613–29. https://doi.org/10.1002/jcp.28820.

Article  CAS  PubMed  Google Scholar 

Drakesmith H, Nemeth E, Ganz T. Ironing out ferroportin. Cell Metab. 2015;22(5):777–87. https://doi.org/10.1016/j.cmet.2015.09.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dunn LL, Suryo Rahmanto Y, Richardson DR. Iron uptake and metabolism in the new millennium. Trends Cell Biol. 2007;17(2):93–100. https://doi.org/10.1016/j.tcb.2006.12.003.

Article  CAS  PubMed  Google Scholar 

Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D’Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014;16(11):1069–79. https://doi.org/10.1038/ncb3053.

Article  CAS  PubMed