Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles
Keywords
Ebola virus
electrostatics
lipid–protein interactions
phosphatidylinositol-4,5-bisphosphate
phosphatidylserine
plasma membrane
virus assembly
virus budding
VP40
AbbreviationsEGFP
enhanced green fluorescent protein
HEK
human embryonic kidney
LPI
lipid–protein interaction
PI(4,5)P2
phosphatidylinositol 4,5-bisphosphate
POPC
1-palmitoyl-2-oleoyl-glycero-3-phosphocholine
POPE
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
POPS
1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine
SPR
surface plasmon resonance
© 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.
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