Hamilton RL. Lewy bodies in Alzheimer’s disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol. 2000;10(3):378–84.

Article  CAS  PubMed  Google Scholar 

Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, et al. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurol. 2017;16(1):55–65.

Article  PubMed  PubMed Central  Google Scholar 

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology. 2017;89(1):88–100.

Article  PubMed  PubMed Central  Google Scholar 

Coughlin DG, Hurtig HI, Irwin DJ. Pathological influences on clinical heterogeneity in Lewy Body Diseases. Mov Disord. 2020;35(1):5–19.

Article  PubMed  Google Scholar 

Chung EJ, Babulal GM, Monsell SE, Cairns NJ, Roe CM, Morris JC. Clinical features of Alzheimer Disease with and without Lewy Bodies. JAMA Neurol. 2015;72(7):789–96.

Article  PubMed  PubMed Central  Google Scholar 

Braak H, Braak E. Staging of Alzheimer’s disease-related neurofibrillary changes. Neurobiol Aging. 1995;16(3):271–8. discussion 8–84.

Article  CAS  PubMed  Google Scholar 

Rezaie P, Cairns NJ, Chadwick A, Lantos PL. Lewy bodies are located preferentially in limbic areas in diffuse Lewy body disease. Neurosci Lett. 1996;212(2):111–4.

Article  CAS  PubMed  Google Scholar 

Nelson PT, Abner EL, Patel E, Anderson S, Wilcock DM, Kryscio RJ, et al. The Amygdala as a locus of pathologic misfolding in neurodegenerative diseases. J Neuropathol Exp Neurol. 2018;77(1):2–20.

Article  CAS  PubMed  Google Scholar 

Nestor PJ, Altomare D, Festari C, Drzezga A, Rivolta J, Walker Z, et al. Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia. Eur J Nucl Med Mol Imaging. 2018;45(9):1509–25.

Article  PubMed  Google Scholar 

Mak E, Su L, Williams GB, O’Brien JT. Neuroimaging characteristics of dementia with Lewy bodies. Alzheimers Res Ther. 2014;6(2):18.

Article  PubMed  PubMed Central  Google Scholar 

Pillai JA, Wu G, Tousi B, Larvie M, Léger GC, Leverenz JB. Amygdala sign, a FDG-PET signature of dementia with Lewy Bodies. Parkinsonism Relat Disord. 2019;64:300–3.

Article  PubMed  PubMed Central  Google Scholar 

Kantarci K, Boeve BF, Przybelski SA, Lesnick TG, Chen Q, Fields J, et al. FDG PET metabolic signatures distinguishing prodromal DLB and prodromal AD. NeuroImage. Clinical. 2021;31:102754.

Google Scholar 

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr., Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–9.

Article  PubMed  Google Scholar 

Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–9.

Article  PubMed  Google Scholar 

McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, et al. Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology. 2020;94(17):743–55.

Article  PubMed  PubMed Central  Google Scholar 

Lee YG, Jeon S, Kang SW, Ye BS. Effects of amyloid beta and dopaminergic depletion on perfusion and clinical symptoms. Alzheimers Dement. 2023;19(12):5719–29.

Article  CAS  PubMed  Google Scholar 

Kang Y, Na D. Seoul Neuropsychological Screening Battery (SNSB): Human Brain Research & Consulting Co. In: Incheon; 2003.

Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging. 2001;20(1):45–57.

Article  CAS  PubMed  Google Scholar 

Patenaude B, Smith SM, Kennedy DN, Jenkinson M. A bayesian model of shape and appearance for subcortical brain segmentation. NeuroImage. 2011;56(3):907–22.

Article  PubMed  Google Scholar 

Rolls ET, Huang CC, Lin CP, Feng J, Joliot M. Automated anatomical labelling atlas 3. NeuroImage. 2020;206:116189.

Article  PubMed  Google Scholar 

Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC. A reproducible evaluation of ANTs similarity metric performance in brain image registration. NeuroImage. 2011;54(3):2033–44.

Article  PubMed  Google Scholar 

Moeller JR, Strother SC. A Regional Covariance Approach to the analysis of functional patterns in Positron Emission Tomographic Data. J Cereb Blood Flow Metabolism. 1991;11(1suppl):A121–35.

Article  CAS  Google Scholar 

Lee YG, Jeon S, Yoo HS, Chung SJ, Lee SK, Lee PH, et al. Amyloid-beta-related and unrelated cortical thinning in dementia with Lewy bodies. Neurobiol Aging. 2018;72:32–9.

Article  CAS  PubMed  Google Scholar 

Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, et al. Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer’s disease: phase 3 study. Alzheimers Dement. 2015;11(8):964–74.

Article  PubMed  Google Scholar 

Nestor PJ, Fryer TD, Smielewski P, Hodges JR. Limbic hypometabolism in Alzheimer’s disease and mild cognitive impairment. Ann Neurol. 2003;54(3):343–51.

Article  PubMed  Google Scholar 

Mosconi L, Tsui WH, De Santi S, Li J, Rusinek H, Convit A, et al. Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology. 2005;64(11):1860–7.

Article  CAS  PubMed  Google Scholar 

Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ Jr., Jennings RG, Brewer JB, et al. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010;256(3):932–42.

Article  PubMed  PubMed Central  Google Scholar 

Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ Jr., et al. Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 2010;31(2):347–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye BS, Lee S, Yoo H, Chung SJ, Lee YH, Choi Y, et al. Distinguishing between dementia with Lewy bodies and Alzheimer’s disease using metabolic patterns. Neurobiol Aging. 2020;87:11–7.

Article  CAS  PubMed  Google Scholar 

Huang C, Ravdin LD, Nirenberg MJ, Piboolnurak P, Severt L, Maniscalco JS, et al. Neuroimaging markers of motor and nonmotor features of Parkinson’s disease: an 18f fluorodeoxyglucose positron emission computed tomography study. Dement Geriatr Cogn Disord. 2013;35(3–4):183–96.

Article  PubMed  Google Scholar 

Diaz-Galvan P, Miyagawa T, Przybelski SA, Lesnick TG, Senjem ML, Jack CR, et al. Brain glucose metabolism and nigrostriatal degeneration in isolated rapid eye movement sleep behaviour disorder. Brain Commun. 2023;5(1):fcad021.

Article  PubMed  PubMed Central  Google Scholar 

Ishii K, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H, Mori E. Relatively preserved hippocampal glucose metabolism in mild Alzheimer’s disease. Dement Geriatr Cogn Disord. 1998;9(6):317–22.

Article  CAS  PubMed  Google Scholar 

Ishii K, Sasaki H, Kono AK, Miyamoto N, Fukuda T, Mori E. Comparison of gray matter and metabolic reduction in mild Alzheimer’s disease using FDG-PET and voxel-based morphometric MR studies. Eur J Nucl Med Mol Imaging. 2005;32(8):959–63.

Article  PubMed  Google Scholar 

Milner B. BMemory and the medial temporal regions of the brain,[in Biology of memory, KH Pribram and DE Broadbent. Eds. New York: Academic; 1970. pp. 29–50.

Google Scholar 

Bonelli SB, Powell RHW, Yogarajah M, Samson RS, Symms MR, Thompson PJ, et al. Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. Brain. 2010;133(4):1186–99.

Article  PubMed  PubMed Central  Google Scholar 

Nagy Z, Jobst KA, Esiri MM, Morris JH, King EM, MacDonald B, et al. Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer’s disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. Dementia. 1996;7(2):76–81.

CAS  PubMed  Google Scholar 

Reitz C, Honig L, Vonsattel JP, Tang MX, Mayeux R. Memory performance is related to amyloid and tau pathology in the hippocampus. J Neurol Neurosurg Psychiatry. 2009;80(7):715–21.

Article  CAS  PubMed  Google Scholar 

Kang S, Yoon SH, Na HK, Lee Y-g, Jeon S, Baik K et al. Neuropsychological comparison of patients with Alzheimer’s Disease and Dementia with Lewy Bodies. J Clin Neurol. 2023;19.

Schneider JA, Arvanitakis Z, Yu L, Boyle PA, Leurgans SE, Bennett DA. Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies. Brain. 2012;135(Pt 10):3005–14.

Article  CAS  PubMed  PubMed Central