Cui R, Editorial (2015) A systematic review of Depression. Curr Neuropharmacol 13(4):480. https://doi.org/10.2174/1570159x1304150831123535

Article  CAS  PubMed  Google Scholar 

Crocq MA (2015) A history of anxiety: from Hippocrates to DSM. Dialogues Clin Neurosci 17(3):319–325. https://doi.org/10.31887/DCNS.2015.17.3/macrocq

Article  PubMed  PubMed Central  Google Scholar 

von Muecke-Heim IA, Ries C, Urbina L, Deussing JM (2021) P2X7R antagonists in chronic stress-based depression models: a review. Eur Arch Psychiatry Clin Neurosci 271(7):1343–1358. https://doi.org/10.1007/s00406-021-01306-3

Article  Google Scholar 

Choi KW, Kim YK, Jeon HJ (2020) Comorbid anxiety and depression: clinical and conceptual consideration and Transdiagnostic Treatment. Adv Exp Med Biol 1191:219–235. https://doi.org/10.1007/978-981-32-9705-0_14

Article  CAS  PubMed  Google Scholar 

Zimmerman M, Kerr S, Kiefer R, Balling C, Dalrymple K (2019) What is anxious depression? Overlap and agreement between different definitions. J Psychiatr Res 109:133–138. https://doi.org/10.1016/j.jpsychires.2018.11.028

Article  PubMed  Google Scholar 

Hasin DS, Sarvet AL, Meyers JL et al (2018) Epidemiology of adult DSM-5 major depressive disorder and its Specifiers in the United States. JAMA Psychiatry 75(4):336–346. https://doi.org/10.1001/jamapsychiatry.2017.4602

Article  PubMed  PubMed Central  Google Scholar 

Lim GY, Tam WW, Lu Y et al (2018) Prevalence of Depression in the community from 30 countries between 1994 and 2014. Sci Rep 8:2861. https://doi.org/10.1038/s41598-018-21243-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park SJ, Hong S, Jang H et al (2018) The prevalence of Chronic Physical diseases Comorbid with Depression among different sex and age groups in South Korea: a Population-based study, 2007–2014. Psychiatry Investig 15(4):370–375. https://doi.org/10.30773/pi.2017.09.11

Article  PubMed  PubMed Central  Google Scholar 

Pomerantz AM, Rose P (2014) Is depression the past tense of anxiety? An empirical study of the temporal distinction. Int J Psychol 49(6):446–452. https://doi.org/10.1002/ijop.12050

Article  PubMed  Google Scholar 

Charney DS, Nestler EJ, Pamela Sklar MD (eds) (2017) Charney & Nestler’s neurobiology of mental illness. Oxford University Press

Starr LR, Hammen C, Connolly NP, Brennan PA (2014) Does relational dysfunction mediate the association between anxiety disorders and later depression? Testing an interpersonal model of comorbidity. Depress Anxiety 31(1):77–86. https://doi.org/10.1002/da.22172

Article  PubMed  Google Scholar 

Kjernisted KD, Bleau P (2004) Long-term goals in the management of acute and chronic anxiety disorders. Can J Psychiatry 49(3 Suppl 1):51S–63S

PubMed  Google Scholar 

Montgomery SA (2019) Depression with high levels of anxiety. Int Clin Psychopharmacol 34(3):109. https://doi.org/10.1097/YIC.0000000000000259

Article  PubMed  Google Scholar 

Boyer P (2000) Do anxiety and depression have a common pathophysiological mechanism? Acta Psychiatr Scand Suppl. ;(406):24–29

Fabrazzo M, Cipolla S, Signoriello S et al (2021) A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa. Eur Psychiatry 64(1):e71 Published 2021 Nov 25. https://doi.org/10.1192/j.eurpsy.2021.2249

Article  PubMed  PubMed Central  Google Scholar 

First MB (2013) Diagnostic and statistical manual of mental disorders, 5th edition, and clinical utility. J Nerv Ment Dis. ;201(9):727–729. https://doi.org/10.1097/NMD.0b013e3182a2168a

Cameron OG (2006) Anxious-depressive comorbidity: effects on HPA axis and CNS noradrenergic functions. Essent Psychopharmacol 7(1):24–34

PubMed  Google Scholar 

Leonard BE, Myint A (2009) The psychoneuroimmunology of depression. Hum Psychopharmacol 24(3):165–175. https://doi.org/10.1002/hup.1011

Article  CAS  PubMed  Google Scholar 

Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE et al (2020) The P2X7 Receptor: Central Hub of Brain Diseases. Front Mol Neurosci 13:124 Published 2020 Jul 31. https://doi.org/10.3389/fnmol.2020.00124

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ribeiro DE, Roncalho AL, Glaser T, Ulrich H, Wegener G, Joca S (2019) P2X7 Receptor Signaling in Stress and Depression. Int J Mol Sci 20(11):2778 Published 2019 Jun 6. https://doi.org/10.3390/ijms20112778

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deussing JM, Arzt E (2018) P2X7 Receptor: A Potential Therapeutic Target for Depression? Trends Mol Med 24(9):736–747. https://doi.org/10.1016/j.molmed.2018.07.005

Article  CAS  PubMed  Google Scholar 

Jimenez-Mateos EM, Smith J, Nicke A, Engel T (2019) Regulation of P2X7 receptor expression and function in the brain. Brain Res Bull 151:153–163. https://doi.org/10.1016/j.brainresbull.2018.12.008

Article  CAS  PubMed  Google Scholar 

Huang Z, Tan S (2021) P2X7 Receptor as a Potential Target for Major Depressive Disorder. Curr Drug Targets 22(10):1108–1120. https://doi.org/10.2174/1389450122666210120141908

Article  CAS  PubMed  Google Scholar 

Kongsui R, Beynon SB, Johnson SJ et al (2014) Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: a cumulative threshold spectra analysis. Brain Behav Immun 42:69–80. https://doi.org/10.1016/j.bbi.2014.05.017

Article  CAS  PubMed  Google Scholar 

Zhao YF, Ren WJ, Zhang Y et al (2022) High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus. Int J Mol Sci 23(3):1904 Published 2022 Feb 8. https://doi.org/10.3390/ijms23031904

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnes J, Mondelli V, Pariante CM (2017) Genetic contributions of inflammation to Depression. Neuropsychopharmacology 42(1):81–98. https://doi.org/10.1038/npp.2016.169

Article  CAS  PubMed  Google Scholar 

Iwata M, Ota KT, Li XY et al (2016) Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biol Psychiatry 80(1):12–22. https://doi.org/10.1016/j.biopsych.2015.11.026

Article  CAS  PubMed  Google Scholar 

Yue N, Huang H, Zhu X et al (2017) Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. J Neuroinflammation. ;14(1):102. Published 2017 May 10. https://doi.org/10.1186/s12974-017-0865-y

Illes P, Verkhratsky A, Tang Y (2020) Pathological ATPergic signaling in Major Depression and Bipolar Disorder. Front Mol Neurosci 12:331 Published 2020 Jan 31. https://doi.org/10.3389/fnmol.2019.00331

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hisaoka-Nakashima K, Azuma H, Ishikawa F et al (2020) Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms. Cells 9(5):1068 Published 2020 Apr 25. https://doi.org/10.3390/cells9051068

Article  CAS  PubMed  PubMed Central  Google Scholar 

Metzger MW, Walser SM, Aprile-Garcia F et al (2017) Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signal 13(2):153–170. https://doi.org/10.1007/s11302-016-9546-z

Article  CAS  PubMed  Google Scholar 

Li H, Ge S, Greene B, Dunbar-Jacob J (2018) Depression in the context of chronic diseases in the United States and China. Int J Nurs Sci 6(1):117–122 Published 2018 Nov 29. https://doi.org/10.1016/j.ijnss.2018.11.007

Article  PubMed  PubMed Central  Google Scholar 

Xie B, Chen Y, Zhang S et al (2014) The expression of P2X7 receptors on peripheral blood mononuclear cells in patients with primary Sjögren’s syndrome and its correlation with anxiety and depression. Clin Exp Rheumatol 32(3):354–360

CAS  PubMed  Google Scholar 

Xu Y, Sheng H, Bao Q, Wang Y, Lu J, Ni X (2016) NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain Behav Immun 56:175–186. https://doi.org/10.1016/j.bbi.2016.02.022

Article  CAS  PubMed  Google Scholar 

Hu SQ, Hu JL, Zou FL et al (2022) P2X7 receptor in inflammation and pain. Brain Res Bull 187:199–209. https://doi.org/10.1016/j.brainresbull.2022.07.006

Article  CAS  PubMed  Google Scholar 

Wu P, Wang Y, Liu Y et al (2023) Emerging roles of the P2X7 receptor in cancer pain. Purinergic Signal 19(2):441–450. https://doi.org/10.1007/s11302-022-09902-1

Article  CAS  PubMed  Google Scholar 

Chen LQ, Lv XJ, Guo QH et al (2023) Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents. Br J Pharmacol 180(8):1090–1113. https://doi.org/10.1111/bph.15994

Article  CAS  PubMed  Google Scholar 

Gil B, Smith J, Tang Y, Illes P, Engel T (2022) Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor.