Kotwas A, Karakiewicz B, Zabielska P et al (2021) Epidemiological factors for type 2 diabetes mellitus: evidence from the Global Burden of Disease. Arch Public Health 79(1):110. https://doi.org/10.1186/s13690-021-00632-1

Article  PubMed  PubMed Central  Google Scholar 

Ribeiro MVMR, Barbosa FT, Ribeiro LEF et al (2016) Clinical features of diabetic patients with dry eye disease in a community in Maceio: a cross-sectional study. Rev Bras Oftalmol 75:121–126. https://doi.org/10.5935/0034-7280.20160026

Article  Google Scholar 

Han SB, Yang HK, Hyon JY (2019) Influence of diabetes mellitus on anterior segment of the eye. Clin Interv Aging 14:53–63. https://doi.org/10.2147/CIA.S190713

Article  CAS  PubMed  Google Scholar 

Liu R, Ma B, Gao Y et al (2019) Tear inflammatory cytokines analysis and clinical correlations in diabetes and nondiabetes with dry eye. Am J Ophthalmol 200:10–15. https://doi.org/10.1016/j.ajo.2018.12.001

Article  CAS  PubMed  Google Scholar 

Galor A, Moein HR, Lee C et al (2018) Neuropathic pain and dry eye. Ocul Surf 16(1):31–44. https://doi.org/10.1016/j.jtos.2017.10.001

Article  PubMed  Google Scholar 

Yoo TK, Oh E (2019) Diabetes mellitus is associated with dry eye syndrome: a meta-analysis. Int Ophthalmol 39(11):2611–2620. https://doi.org/10.1007/s10792-019-01110-y

Article  PubMed  Google Scholar 

Ding N, Wei Q, Deng W et al (2021) Electroacupuncture alleviates inflammation of dry eye diseases by regulating the α 7nAChR/NF- κ B signaling pathway. Oxid Med Cell Longev 2021:6673610. https://doi.org/10.1155/2021/6673610

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yt Yang, Wei BJ, Zhao Y et al (2020) Effects of electroacupuncture on conjunctival cell apoptosis and the expressions of apoptosis-related proteins Caspase-3, Fas and Bcl-2 in rabbits with dry eye syndrome. J Acupunct Tuina Sci 18:16–23. https://doi.org/10.1007/s11726-020-1152-5

Article  Google Scholar 

Sun XY, Shen HX, Liu CY et al (2022) Acupuncture mitigates ocular surface inflammatory response via α7nAChR/NF-κB p65 signaling in dry eye guinea pigs. Zhen Ci Yan Jiu 47(11):975–82. https://doi.org/10.13702/j.1000-0607.20220015

Article  PubMed  Google Scholar 

Xue Y, Zhao YD, Yuan YJ et al (2017) 32 cases of dry eye of diabetes with deficiency of both qi and yin treated with acupuncture method of “entering fire and tonifying.” Res Tradit Chin Med 30(11):50–52

Google Scholar 

Liu Y, Huang H, Gao R et al (2020) Dynamic phenotypes and molecular mechanisms to understand the pathogenesis of diabetic nephropathy in two widely used animal models of type 2 diabetes mellitus. Front Cell Dev Biol 8:172. https://doi.org/10.3389/fcell.2020.00172

Article  PubMed  PubMed Central  Google Scholar 

Sen Y, Wu Y, Zheng Z et al (2022) Impacts of electroacupuncture at auricular concha on gastrointestinal motility in the rats with type 2 diabetes. World J Acupunct-Moxibustion 32(2):142–148. https://doi.org/10.1016/j.wjam.2021.11.008

Article  Google Scholar 

Fakih D, Zhao Z, Nicolle P et al (2019) Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem. J Neuroinflammation 16(1):268. https://doi.org/10.1186/s12974-019-1656-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li ZR (2003) Experimental acupuncture and moxibustion, 2nd edn. China Traditional Chinese Medicine Press, Beijing

Jin T, Liu X, Li Y et al (2023) Electroacupuncture reduces ocular surface neuralgia in dry-eyed guinea pigs by inhibiting the trigeminal ganglion and spinal trigeminal nucleus caudalis P2X 3 R-PKC signaling pathway. Curr Eye Res 48(6):546–556. https://doi.org/10.1080/02713683.2023.2176886

Article  CAS  PubMed  Google Scholar 

Chen ZX, Li Y, Zhang XG et al (2017) Sham electroacupuncture methods in randomized controlled trials. Sci Rep 7:40837. https://doi.org/10.1038/srep40837

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Chi XS, Li R et al (2017) Inhibition of P2X7 receptor ameliorates nuclear factor-kappa B mediated neuroinflammation induced by status epilepticus in rat hippocampus. J Mol Neurosci 63(2):173–184. https://doi.org/10.1007/s12031-017-0968-z

Article  CAS  PubMed  Google Scholar 

Bereiter DA, Rahman M, Ahmed F et al (2022) Title: P2x7 receptor activation and estrogen status drive neuroinflammatory mechanisms in a rat model for dry eye. Front Pharmacol 13:827244. https://doi.org/10.3389/fphar.2022.827244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu H, Lin L, Du X et al (2020) Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease. Biomed Pharmacother 127:110051. https://doi.org/10.1016/j.biopha.2020.110051

Article  CAS  PubMed  Google Scholar 

Li H, Wei F, Li S et al (2020) The effect of sinomenine eye drops on experimental dry eye in mice. Cutan Ocul Toxicol 39(4):389–395. https://doi.org/10.1080/15569527.2020.1840580

Article  CAS  PubMed  Google Scholar 

Skrzypecki J, Huc T, Ciepiaszuk K et al (2019) Effect of TMAO, a gut-bacteria metabolite, on dry eye in a rat model. Curr Eye Res 44(6):651–656. https://doi.org/10.1080/02713683.2019.1574834

Article  CAS  PubMed  Google Scholar 

Bereiter DA, Rahman M, Thompson R et al (2018) TRPV1 and TRPM8 channels and nocifensive behavior in a rat model for dry eye. Invest Ophthalmol Vis Sci 59(8):3739–3746. https://doi.org/10.1167/iovs.18-24304

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mishra A, Behura A, Kumar A et al (2021) P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases. Eur J Pharmacol 906:174235. https://doi.org/10.1016/j.ejphar.2021.174235

Article  CAS  PubMed  Google Scholar 

Siedlecki AN, Smith SD, Siedlecki AR et al (2020) Ocular pain response to treatment in dry eye patients. Ocul Surf 18(2):305–311. https://doi.org/10.1016/j.jtos.2019.12.004

Article  PubMed  Google Scholar 

Sharma BR, Kanneganti TD (2021) NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol 22(5):550–559. https://doi.org/10.1038/s41590-021-00886-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ai X, Hou Y, Wang X et al (2019) Amelioration of dry eye syndrome in db/db mice with diabetes mellitus by treatment with Tibetan Medicine Formula Jikan Mingmu Drops. J Ethnopharmacol 241:111992. https://doi.org/10.1016/j.jep.2019.111992

Article  PubMed  Google Scholar 

Liu H, Sheng M, Liu Y et al (2015) Expression of SIRT1 and oxidative stress in diabetic dry eye. Int J Clin Exp Pathol 8(6):7644–7653

PubMed  PubMed Central  Google Scholar 

Zhou Q, Yang L, Wang Q et al (2022) Mechanistic investigations of diabetic ocular surface diseases. Front Endocrinol 13:1079541. https://doi.org/10.3389/fendo.2022.1079541. (Lausanne)

Article  Google Scholar 

Priyadarsini S, Whelchel A, Nicholas SE et al (2020) Diabetic keratopathy: Insights and challenges. Surv Ophthalmol 65(5):513–529. https://doi.org/10.1016/j.survophthal.2020.02.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xue J-F, Zhang B, Dou S et al (2021) Revealing the angiopathy of lacrimal gland lesion in type 2 diabetes. Front Physiol 12(0):0–0. https://doi.org/10.3389/fphys.2021.731234

Zeng X, Lv Y, Zhongxiu Gu et al (2019) The effects of diabetic duration on lacrimal functional unit in patients with type II diabetes. J Ophthalmol 2019:1–11. https://doi.org/10.1155/2019/8127515

Article  CAS  Google Scholar 

Mingli Qu, Wan L, Dong M et al (2021) Hyperglycemia-induced severe mitochondrial bioenergetic deficit of lacrimal gland contributes to the early onset of dry eye in diabetic mice. Free Radical Biol Med 166:313–323. https://doi.org/10.1016/j.freeradbiomed.2021.02.036

Article  CAS  Google Scholar 

Amorim M, Martins B, Caramelo F et al (2022) Putative biomarkers in tears for diabetic retinopathy diagnosis. Front Med 9(0):0–0. https://doi.org/10.3389/fmed.2022.873483

Zhang C, Xi L, Zhao S et al (2016) Interleukin-1β and tumour necrosis factor-α levels in conjunctiva of diabetic patients with symptomatic moderate dry eye: case–control study. BMJ Open 6(8):e010979–e010979. https://doi.org/10.1136/bmjopen-2015-010979

Article  PubMed  PubMed Central  Google Scholar 

Guo Y, Zhang H, Zhao Z et al (2022) Hyperglycemia induces meibomian gland dysfunction. Invest Ophthalmol Vis Sci 63(1):30–30. https://doi.org/10.1167/iovs.63.1.30

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu H, Fang X, Luo S et al (2022) Meibomian glands and tear film findings in type 2 diabetic patients: a cross-sectional study. Front Med 9(0):0–0. https://doi.org/10.3389/fmed.2022.762493

Di Zazzo A, Coassin M, Micera A et al (2021) Ocular surface diabetic disease: a neurogenic condition? Ocul Surf 19:218–223. https://doi.org/10.1016/j.jtos.2020.09.006

Article  PubMed  Google Scholar 

Badian RA, Ekman L, Pripp AH et al (2023) Comparison of novel wide-field in vivo corneal confocal microscopy with skin biopsy for assessing peripheral neuropathy in type 2 diabetes. Diabetes 72(7):908–917. https://doi.org/10.2337/db22-0863

Article  CAS  PubMed  PubMed Central