Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Biller LH, Schrag D. Diagnosis and treatment of metastatic colorectal Cancer: a review. JAMA. 2021;325(7):669–85.

Article  CAS  PubMed  Google Scholar 

Gerstberger S, Jiang Q, Ganesh K. Metastasis Cell. 2023;186(8):1564–79.

CAS  PubMed  Google Scholar 

Seely KD, Morgan AD, Hagenstein LD, Florey GM, Small JM. Bacterial involvement in Progression and Metastasis of Colorectal Neoplasia. Cancers (Basel), 2022. 14(4).

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin, 2021. 71(1): pp. 7–33.

Fleischer JR, Schmitt AM, Haas G, Xu X, Zeisberg EM, Bohnenberger H, et al. Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution. Mol Cancer. 2023;22(1):17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng Z, Hou X, Bian Z, Jia W, Zhao L. Gut Microbiota Colorectal cancer Metastasis Cancer Lett. 2023;555:216039.

CAS  PubMed  Google Scholar 

Yu J, Feng Q, Wong SH, Zhang D, Liang QY, Qin Y, et al. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut. 2017;66(1):70–8.

Article  CAS  PubMed  Google Scholar 

Qu R, Zhang Y, Ma Y, Zhou X, Sun L, Jiang C, et al. Role of the gut microbiota and its metabolites in tumorigenesis or development of Colorectal Cancer. Adv Sci (Weinh). 2023;10(23):e2205563.

Article  PubMed  Google Scholar 

Song M, Chan AT, Sun J. Influence of the gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer. Gastroenterology. 2020;158(2):322–40.

Article  CAS  PubMed  Google Scholar 

Zhao Y, Wang C, Goel A. Role of gut microbiota in epigenetic regulation of colorectal Cancer. Biochim Biophys Acta Rev Cancer. 2021;1875(1):188490.

Article  CAS  PubMed  Google Scholar 

Henstra C, van Praagh J, Olinga P, Nagelkerke A. The gastrointestinal microbiota in colorectal cancer cell migration and invasion. Clin Exp Metastasis. 2021;38(6):495–510.

Article  CAS  PubMed  Google Scholar 

Chen YC, Chuang CH, Miao ZF, Yip KL, Liu CJ, Li LH, et al. Gut microbiota composition in chemotherapy and targeted therapy of patients with metastatic colorectal cancer. Front Oncol. 2022;12:955313.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan Z, Sun W, Li Y, Jiao X, Zhu M, Zhang J et al. Current progress of EMT: a New Direction of targeted therapy for Colorectal Cancer with Invasion and Metastasis. Biomolecules, 2022. 12(12).

Lemoine L, Sugarbaker P, Van der Speeten K. Pathophysiology of colorectal peritoneal carcinomatosis: role of the peritoneum. World J Gastroenterol. 2016;22(34):7692–707.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shin AE, Giancotti FG, Rustgi AK. Metastatic colorectal cancer: mechanisms and emerging therapeutics. Trends Pharmacol Sci. 2023;44(4):222–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fejes Z, Kiraly IE, Feher AM, Kovacs PG, Gyuris Z, Sukosd F, et al. Multifocal Urinary Tract Metastasis Colorectal Carcinoma Pathobiology. 2022;89(1):56–62.

CAS  PubMed  Google Scholar 

Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 2014;14(3):159–72.

Article  CAS  PubMed  Google Scholar 

Xu J, Fan J, Qin X, Cai J, Gu J, Wang S, et al. Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (version 2018). J Cancer Res Clin Oncol. 2019;145(3):725–36.

Article  PubMed  Google Scholar 

Wang Y, Zhong X, He X, Hu Z, Huang H, Chen J, et al. Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches. J Exp Clin Cancer Res. 2023;42(1):177.

Article  PubMed  PubMed Central  Google Scholar 

Gracia-Sancho J, Caparros E, Fernandez-Iglesias A, Frances R. Role of liver sinusoidal endothelial cells in liver diseases. Nat Rev Gastroenterol Hepatol. 2021;18(6):411–31.

Article  PubMed  Google Scholar 

Zheng M, Tian Z. Liver-mediated adaptive Immune Tolerance. Front Immunol. 2019;10:2525.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zvibel I, Wagner A, Pasmanik-Chor M, Varol C, Oron-Karni V, Santo EM, et al. Transcriptional profiling identifies genes induced by hepatocyte-derived extracellular matrix in metastatic human colorectal cancer cell lines. Clin Exp Metastasis. 2013;30(2):189–200.

Article  CAS  PubMed  Google Scholar 

Fan X, Meng M, Li B, Chen H, Tan J, Xu K, et al. Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay. J Transl Med. 2023;21(1):260.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang MY, Lee HH, Huang CW, Huang CM, Ma CJ, Yin TC, et al. ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX-based neoadjuvant concurrent chemoradiation. Oncol Lett. 2020;20(5):212.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Huang S, Lu X, Huang Y, Chi P. Incidence of and risk factors for gastroepiploic lymph node involvement in patients with Cancer of the transverse Colon including the hepatic flexure. World J Surg. 2021;45(5):1514–25.

Article  PubMed  Google Scholar 

Wang Y, Sun Y, Li X, Yu X, Zhang K, Liu J, et al. Progress in the treatment of malignant ascites. Crit Rev Oncol Hematol. 2024;194:104237.

Article  PubMed  Google Scholar 

Kucukkose E, Heesters BA, Villaudy J, Verheem A, Cercel M, van Hal S et al. Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice. J Immunother Cancer, 2022. 10(12).

Wu J, Long Y, Li M, He Q. Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: interfering with the crosstalk between seed and soil. Acta Pharm Sin B. 2021;11(8):2286–305.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yachida S, Mizutani S, Shiroma H, Shiba S, Nakajima T, Sakamoto T, et al. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat Med. 2019;25(6):968–76.

Article  CAS  PubMed  Google Scholar 

Nakatsu G, Li X, Zhou H, Sheng J, Wong SH, Wu WK, et al. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun. 2015;6:8727.

Article  CAS  PubMed  Google Scholar 

Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 2017;358(6369):1443–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin H, Miao Z, Wang L, Su B, Liu C, Jin Y, et al. Fusobacterium nucleatum promotes liver metastasis in colorectal cancer by regulating the hepatic immune niche and altering gut microbiota. Aging. 2022;14(4):1941–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertocchi A, Carloni S, Ravenda PS, Bertalot G, Spadoni I, Lo Cascio A, et al. Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver. Cancer Cell. 2021;39(5):708–e72411.

Article  CAS  PubMed  Google Scholar 

Nicolosi D, Scalia M, Nicolosi VM, Pignatello R. Encapsulation in fusogenic liposomes broadens the spectrum of action of Vancomycin against Gram-negative bacteria. Int J Antimicrob Agents. 2010;35(6):553–8.

Article  CAS  PubMed  Google Scholar 

Palleja A, Mikkelsen KH, Forslund SK, Kashani A, Allin KH, Nielsen T, et al. Recovery of gut microbiota of healthy adults following antibiotic exposure. Nat Microbiol. 2018;3(11):1255–65.

Article  CAS  PubMed  Google Scholar 

Yuan N, Li X, Wang M, Zhang Z, Qiao L, Gao Y, et al. Gut Microbiota Alteration influences Colorectal Cancer Metastasis to the liver by remodeling the liver Immune Microenvironment. Gut Liver. 2022;16(4):575–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan X, Liu L, Li H, Qin H, Sun Z. Clinical significance of Fusobacterium nucleatum, epithelial-mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients. Onco Targets Ther. 2017;10:5031–46.

Article  PubMed  PubMed Central  Google Scholar 

Hanus M, Parada-Venegas D, Landskron G, Wielandt AM, Hurtado C, Alvarez K, et al. Immune System, Microbiota, and Microbial metabolites: the Unresolved Triad in Colorectal Cancer Microenvironment. Front Immunol. 2021;12:612826.

Article  CAS 

留言 (0)

沒有登入
gif