Jiang WW, Zhang ZZ, He PP, Jiang LP, Chen JZ, Zhang XT, Hu M, Zhang YK, Ouyang XP. Emerging roles of growth differentiation factor-15 in brain disorders (Review). Exp Ther Med. 2021;22:1270.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y-J, Li Z-X, Gu H-Q, Zhai Y, Jiang Y, Zhao X-Q, Wang Y-L, Yang X, Wang C-J, Meng X, et al. China stroke statistics 2019: a report from the national center for healthcare quality management in neurological diseases, china national clinical research center for neurological diseases, the Chinese stroke association, national center for chronic and non-communicable disease control and prevention, chinese center for disease control and prevention and institute for global neuroscience and stroke collaborations. Stroke Vasc Neurol. 2020;5:211–39.

Article  PubMed  PubMed Central  Google Scholar 

Wafa HA, Wolfe CDA, Emmett E, Roth GA, Johnson CO, Wang Y. Burden of stroke in Europe: thirty-year projections of incidence, prevalence, deaths, and disability-adjusted life years. Stroke. 2020;51:2418–27.

Article  PubMed  PubMed Central  Google Scholar 

Barthels D, Das H. Current advances in ischemic stroke research and therapies. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165260.

Article  CAS  PubMed  Google Scholar 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–5.

Article  CAS  PubMed  Google Scholar 

Vallés J, Lago A, Santos MT, Latorre AM, Tembl JI, Salom JB, Nieves C, Moscardó A. Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance. Thromb Haemost. 2017;117:1919–29.

Article  PubMed  Google Scholar 

Borregaard N. Neutrophils, from marrow to microbes. Immunity. 2010;33:657–70.

Article  CAS  PubMed  Google Scholar 

Segal AW. How neutrophils kill microbes. Annu Rev Immunol. 2005;23:197–223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006;6:173–82.

Article  CAS  PubMed  Google Scholar 

Bainton DF. Distinct granule populations in human neutrophils and lysosomal organelles identified by immuno-electron microscopy. J Immunol Methods. 1999;232:153–68.

Article  CAS  PubMed  Google Scholar 

Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood. 1997;89:3503–21.

Article  CAS  PubMed  Google Scholar 

Movitz C, Dahlgren C. Quantification of annexin I in subcellular fractions of human neutrophils reveals an exclusive cytosolic localisation. Cell Biol Int. 2001;25:963–9.

Article  CAS  PubMed  Google Scholar 

Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77:598–625.

Article  CAS  PubMed  Google Scholar 

Reber LL, Gillis CM, Starkl P, Jönsson F, Sibilano R, Marichal T, Gaudenzio N, Bérard M, Rogalla S, Contag CH, et al. Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide. J Exp Med. 2017;214:1249–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pleskova SN, Mikheeva ER, Razumkova EV, Gornostaeva EE. The effect of magnetite nanoparticles and bacteria on the activity of NADPH-Oxidase and myeloperoxidase in neutrophils of human blood. Cell and Tissue Biology. 2018;12:120–6.

Article  Google Scholar 

Wang YC, Lu YB, Huang XL, Lao YF, Zhang L, Yang J, Shi M, Ma HL, Pan YW, Zhang YN. Myeloperoxidase: a new target for the treatment of stroke? Neural Regen Res. 2022;17:1711–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang SU, O’Sullivan KM. The expanding role of extracellular traps in inflammation and autoimmunity: the new players in casting dark webs. Int J Mol Sci. 2022;23:3793.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steinberg BE, Grinstein S. Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death. Sci STKE. 2007;2007:pe11.

Article  PubMed  Google Scholar 

Vorobjeva N, Galkin I, Pletjushkina O, Golyshev S, Zinovkin R, Prikhodko A, Pinegin V, Kondratenko I, Pinegin B, Chernyak B. Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165664.

Article  CAS  PubMed  Google Scholar 

Tatsiy O, McDonald PP. Physiological stimuli induce PAD4-Dependent, ROS-Independent NETosis, with early and late events controlled by discrete signaling pathways. Front Immunol. 2018;9:2036.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Zhang H, Hu X, Cai W, Ni W, Zhou K. Role of NETosis in central nervous system injury. Oxid Med Cell Longev. 2022;2022:3235524.

PubMed  PubMed Central  Google Scholar 

Metzler KD, Goosmann C, Lubojemska A, Zychlinsky A, Papayannopoulos V. A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis. Cell Rep. 2014;8:883–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 2010;191:677–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delgado-Rizo V, Martínez-Guzmán MA, Iñiguez-Gutierrez L, García-Orozco A, Alvarado-Navarro A, Fafutis-Morris M. Neutrophil extracellular traps and its implications in inflammation: an overview. Front Immunol. 2017;8:81.

Article  PubMed  PubMed Central  Google Scholar 

Yousefi S, Mihalache C, Kozlowski E, Schmid I, Simon HU. Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. Cell Death Differ. 2009;16:1438–44.

Article  CAS  PubMed  Google Scholar 

Yipp BG, Kubes P. NETosis: how vital is it? Blood. 2013;122:2784–94.

Article  CAS  PubMed  Google Scholar 

Parker H, Albrett AM, Kettle AJ, Winterbourn CC. Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. J Leukoc Biol. 2012;91:369–76.

Article  CAS  PubMed  Google Scholar 

Kambas K, Mitroulis I, Ritis K. The emerging role of neutrophils in thrombosis-the journey of TF through NETs. Front Immunol. 2012;3:385.

Article  PubMed  PubMed Central  Google Scholar 

Zhou P, Li T, Jin J, Liu Y, Li B, Sun Q, Tian J, Zhao H, Liu Z, Ma S, et al. Interactions between neutrophil extracellular traps and activated platelets enhance procoagulant activity in acute stroke patients with ICA occlusion. EBioMedicine. 2020;53:102671.

Article  PubMed  PubMed Central  Google Scholar 

von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209:819–35.

Article  Google Scholar 

Wang Y, Luo L, Braun O, Westman J, Madhi R, Herwald H, Mörgelin M, Thorlacius H. Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice. Sci Rep. 2018;8:4020.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Du F, Hawez A, Mörgelin M, Thorlacius H. Neutrophil extracellular trap-microparticle complexes trigger neutrophil recruitment via high-mobility group protein 1 (HMGB1)-toll-like receptors(TLR2)/TLR4 signalling. Br J Pharmacol. 2019;176:3350–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma YH, Ma TT, Wang C, Wang H, Chang DY, Chen M, Zhao MH. High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation. Arthritis Res Ther. 2016;18:2.

Article  PubMed  PubMed Central  Google Scholar 

Laridan E, Denorme F, Desender L, François O, Andersson T, Deckmyn H, Vanhoorelbeke K, De Meyer SF. Neutrophil extracellular traps in ischemic stroke thrombi. Ann Neurol. 2017;82:223–32.

Article  CAS  PubMed  Google Scholar 

Wang Y, Liu Y. Neutrophil-Induced Liver Injury and Interactions Between Neutrophils and Liver Sinusoidal Endothelial Cells. Inflammation. 2021;44:1246–62.

Article  CAS  PubMed  Google Scholar 

Westlin WF, Gimbrone MA Jr. Neutrophil-mediated damage to human vascular endothelium. Role of cytokine activation. Am J Pathol. 1993;142:117–28.