Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy

Friedman SL, Pinzani M. Hepatic fibrosis 2022: unmet needs and a blueprint for the future. Hepatology. 2022;75:473–88.

Article  CAS  PubMed  Google Scholar 

Matsuda M, Seki E. Hepatic stellate cell-macrophage crosstalk in liver fibrosis and carcinogenesis. Semin Liver Dis. 2020;40:307–20.

Article  PubMed  PubMed Central  Google Scholar 

Liu Yi, Que KT, Yang PF. TREM2 promotes liver fibrosis by enhancing hepatic stellate cell endocytosis and activation via phosphorylating ITGAV. J Biol Regul Homeost Agents. 2023;37:3693–704.

CAS  Google Scholar 

Khanam A, Saleeb PG, Kottilil S. Pathophysiology and treatment options for hepatic fibrosis: can it be completely cured? Cells. 2021;10:1097.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parola M, Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med. 2019;65:37–55.

Article  CAS  PubMed  Google Scholar 

Rao J, Cheng F, Zhou H, Yang W, Qiu J, Yang C, et al. Nogo-B is a key mediator of hepatic ischemia and reperfusion injury. Redox Biol. 2020;37:101745.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oertle T, Schwab ME. Nogo and its paRTNers. Trends Cell Biol. 2003;13:187–94.

Article  CAS  PubMed  Google Scholar 

Teng FY, Tang BL. Cell autonomous function of Nogo and reticulons: The emerging story at the endoplasmic reticulum. J Cell Physiol. 2008;216:303–8.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Huo W, Wen Y, Li H. Silencing Nogo-B receptor inhibits penile corpus cavernosum vascular smooth muscle cell apoptosis of rats with diabetic erectile dysfunction by down-regulating ICAM-1. PLoS One. 2019;14:e0220715.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong C, Liu Y, Jiang K, Wang H, Qu W, Zhang C, et al. The Nogo-B receptor promotes human hepatocellular carcinoma cell growth via the Akt signal pathway. J Cell Biochem. 2018;119:7738–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen M, Men R, Yang Z, Dan X, Wu W, Liu X, et al. The value of circulating Nogo-B for evaluating hepatic functional reserve in patients with cirrhosis. Dis Markers. 2015;2015:419124.

Article  PubMed  PubMed Central  Google Scholar 

Yang Q, Zhang C, Xie H, Tang L, Liu D, Qiu Q, et al. Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways. Biochem Biophys Res Commun. 2021;581:96–102.

Article  CAS  PubMed  Google Scholar 

Tadokoro KS, Rana U, Jing X, Konduri GG, Miao QR, Teng RJ. Nogo-B receptor modulates pulmonary artery smooth muscle cell function in developing lungs. Am J Respir Cell Mol Biol. 2016;54:892–900.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez-Diaz I, Pan J, Ricciardi CA, Bai X, Ke J, White KE, et al. Overexpression of circulating soluble Nogo-B improves diabetic kidney disease by protecting the vasculature. Diabetes. 2019;68:1841–52.

Article  CAS  PubMed  Google Scholar 

Li YK, Xie YJ, Wu DC, Long SL, Tang S, Mo ZC. Nogo-B receptor in relevant carcinoma: Current achievements, challenges and aims (Review). Int J Oncol. 2018;53:1827–35.

CAS  PubMed  Google Scholar 

Zhao D, Xue C, Yang Y, Li J, Wang X, Chen Y, et al. Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization. Biomed Pharmacother. 2022;153:113444.

Article  CAS  PubMed  Google Scholar 

Mallat A, Lodder J, Teixeira-Clerc F, Moreau R, Codogno P, Lotersztajn S. Autophagy: a multifaceted partner in liver fibrosis. Biomed Res Int. 2014;2014:869390.

Article  PubMed  PubMed Central  Google Scholar 

Cadwell K. Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat Rev Immunol. 2016;16:661–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antonioli M, Di Rienzo M, Piacentini M, Fimia GM. Emerging mechanisms in initiating and terminating autophagy. Trends Biochem Sci. 2017;42:28–41.

Article  CAS  PubMed  Google Scholar 

Ba L, Gao J, Chen Y, Qi H, Dong C, Pan H, et al. Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways. Phytomedicine. 2019;58:152765.

Article  CAS  PubMed  Google Scholar 

Varshney P, Saini N. PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1795–803.

Article  CAS  PubMed  Google Scholar 

Filali-Mouncef Y, Hunter C, Roccio F, Zagkou S, Dupont N, Primard C, et al. The ménage à trois of autophagy, lipid droplets and liver disease. Autophagy. 2022;18:50–72.

Article  CAS  PubMed  Google Scholar 

Xu J, Wu ZS, Wang Z, Le J, Zheng T, Jia L. Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs. Biomaterials. 2017;120:57–65.

Article  CAS  PubMed  Google Scholar 

Feng T, Tammineni P, Agrawal C, Jeong YY, Cai Q. Autophagy-mediated regulation of BACE1 protein trafficking and degradation. J Biol Chem. 2017;292:1679–90.

Article  CAS  PubMed  Google Scholar 

Du X, Huo X, Yang Y, Hu Z, Botchway BOA, Jiang Y, et al. miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice. Toxicol Lett. 2017;280:195–205.

Article  CAS  PubMed  Google Scholar 

Adori M, Bhat S, Gramignoli R, Valladolid-Acebes I, Bengtsson T, Uhlèn M, et al. Hepatic innervations and nonalcoholic fatty liver disease. Semin Liver Dis. 2023;43:149–62.

Article  PubMed  PubMed Central  Google Scholar 

Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology. 2009;50:1294–306.

Article  CAS  PubMed  Google Scholar 

Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y. Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. Am J Pathol. 2013;182:786–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng Y, Lin J, Liu D, Wan G, Gu X, Ma J. Nogo-B promotes angiogenesis and improves cardiac repair after myocardial infarction via activating Notch1 signaling. Cell Death Dis. 2022;13:306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cervellati C, Valacchi G, Zuliani G. BACE1: from biomarker to Alzheimer’s disease therapeutical target. Aging. 2021;13:12299–300.

Article  PubMed  PubMed Central  Google Scholar 

Bazzari FH, Bazzari AH. BACE1 inhibitors for Alzheimer’s disease: the past, present and any future? Molecules. 2022;27:8823.

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif