Siegel RL, et al. Cancer statistics. CA Cancer J Clin. 2022;72(1):7–33.

Article  PubMed  Google Scholar 

Chansky K, et al. The IASLC lung cancer staging project: external validation of the revision of the TNM stage groupings in the eighth edition of the TNM classification of lung cancer. J Thorac Oncol. 2017;12(7):1109–21.

Article  PubMed  Google Scholar 

Wang X, et al. Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11. Cancer Res. 2021;81(20):5217–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu C, et al. SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling. J Clin Invest. 2022;132(5): e141797.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadeghzadeh Z, et al. Upregulation of fucosyltransferase 3, 8 and protein O-fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs). Glycoconj J. 2020;37(3):319–27.

Article  CAS  PubMed  Google Scholar 

Peng Z, et al. Curcumol controls choriocarcinoma stem-like cells self-renewal via repression of DNA Methyltransferase (DNMT)- and histone deacetylase (HDAC)-mediated epigenetic regulation. Med Sci Monit. 2018;24(24):461–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tchoghandjian A, et al. Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB. Cell Death Differ. 2014;21(5):735–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu C, et al. MicroRNA-183 promotes migration and invasion of CD133(+)/CD326(+) lung adenocarcinoma initiating cells via PTPN4 inhibition. Tumour Biol. 2016;37(8):11289–97.

Article  CAS  PubMed  Google Scholar 

Bao B, et al. Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer. Stem Cells Dev. 2014;23(16):1947–58.

Article  CAS  PubMed  Google Scholar 

Kaufhold S, et al. Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. J Exp Clin Cancer Res. 2016;25(35):84.

Article  Google Scholar 

Chen Y, et al. Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. Science. 2021;373(6562):1537–40.

Article  CAS  PubMed  Google Scholar 

Ma XL, et al. Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target. BMC Cancer. 2019;19(1):760.

Article  PubMed  PubMed Central  Google Scholar 

Laranjo M, et al. Obtaining cancer stem cell spheres from gynecological and breast cancer tumors. J Vis Exp. 2020;157:e60022.

Google Scholar 

Zhang H, et al. Epigenetic signature associated with thyroid cancer progression and metastasis. Semin Cancer Biol. 2022;83:261–8.

Article  CAS  PubMed  Google Scholar 

Cai SF, et al. Genetic and epigenetic determinants of AML pathogenesis. Semin Hematol. 2019;56(2):84–9. https://doi.org/10.1053/j.seminhematol.2018.08.001. (Epub 2018 Aug 22).

Article  PubMed  Google Scholar 

Hanniford D, et al. Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis. Cancer Cell. 2020;37(1):55-70.e15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnstone SE, et al. Large-scale topological changes restrain malignant progression in colorectal cancer. Cell. 2020;182(6):1474-1489.e23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu XY, et al. DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer. J Biochem. 2020;168(2):151–7.

Article  CAS  PubMed  Google Scholar 

Fu Y, et al. The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis. Signal Transduct Target Ther. 2022;7(1):81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu CC, et al. IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation. Int J Cancer. 2015;136(3):547–59.

Article  CAS  PubMed  Google Scholar 

Wang JK, et al. MicroRNA-125 in immunity and cancer. Cancer Lett. 2019;10(454):134–45.

Article  Google Scholar 

Pan G, et al. EMT-associated microRNAs and their roles in cancer stemness and drug resistance. Cancer Commun (Lond). 2021;41(3):199–217.

Article  PubMed  Google Scholar 

Zhong S, et al. miRNAs in lung cancer a systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer. Transl Res. 2021;230:164–96.

Article  CAS  PubMed  Google Scholar 

Dou H, et al. Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer. Int J Clin Exp Med. 2015;8(6):9291–8.

PubMed  PubMed Central  Google Scholar 

Zhang YJ, et al. MiR-152 regulates metastases of non-small cell lung cancer cells by targeting neuropilin-1. Int J Clin Exp Pathol. 2015;8(11):14235–40.

CAS  PubMed  PubMed Central  Google Scholar 

Sengupta D, et al. DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop. Exp Cell Res. 2016;346(2):176–87.

Article  CAS  PubMed  Google Scholar 

Liu P, et al. Silencing of miR-152 contributes to DNMT1-mediated CpG methylation of the PTEN promoter in bladder cancer. Life Sci. 2020;15(261): 118311.

Article  Google Scholar 

Chen Y, et al. Identifying key genes for nasopharyngeal carcinoma by prioritized consensus differentially expressed genes caused by aberrant methylation. J Cancer. 2021;12(3):874–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee BB, et al. Metformin regulates expression of DNA methyltransferases through the miR-148/-152 family in non-small lung cancer cells. Clin Epigenetics. 2023;15(1):48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong GS, et al. Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med. 2018;24(7):968–77. https://doi.org/10.1038/s41591-018-0022-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alles J, et al. MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins. Oncotarget. 2017;8(34):56417–27. https://doi.org/10.18632/oncotarget.17662.

Article  PubMed  PubMed Central  Google Scholar 

Zhou C, et al. Discovery of the first-in-class agonist-based SOS1 PROTACs effective in human cancer cells harboring various KRAS mutations. J Med Chem. 2022;65(5):3923–42.

Article  CAS  PubMed  Google Scholar 

Bian Y, et al. Development of SOS1 inhibitor-based degraders to target KRAS-mutant colorectal cancer. J Med Chem. 2022;65(24):16432–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hofmann MH, et al. BI-3406, a potent and selective SOS1-KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition. Cancer Discov. 2021;11(1):142–57.

Article  CAS  PubMed  Google Scholar 

Chandrashekar DS, Karthikeyan SK, Korla PK, et al. UALCAN: an update to the integrated cancer data analysis platform. Neoplasia. 2022;25:18–27. https://doi.org/10.1016/j.neo.2022.01.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–102. https://doi.org/10.1093/nar/gkx247.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang B, Huang S, Chen H, et al. DNMT3B regulates proliferation of A549 cells through the microRNA-152-3p/NCAM1 pathway. Oncol Lett. 2022;23(1):11. https://doi.org/10.3892/ol.2021.13129.

Article  CAS  PubMed  Google Scholar