Krauß L, Schneider C, Hessmann E, Saur D, Schneider G. Epigenetic control of pancreatic cancer metastasis. Cancer Metastasis Rev. 2023. https://doi.org/10.1007/s10555-023-10132-z.

Article  PubMed  PubMed Central  Google Scholar 

Iorgulescu JB, Sun C, Neff C, Cioffi G, Gutierrez C, Kruchko C, Ruhl J, Waite KA, Negoita S, Hofferkamp J, Tihan T, McLendon R, Brat DJ, Ostrom QT, Barnholtz-Sloan JS. Molecular biomarker-defined brain tumors: Epidemiology, validity, and completeness in the United States. Neuro Oncol. 2022;24(11):1989-2000. https://doi.org/10.1093/neuonc/noac113. Erratum in: Neuro Oncol. 2023 Feb 14;25(2):424-9.

Ruffin AT, Li H, Vujanovic L, Zandberg DP, Ferris RL, Bruno TC. Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment. Nat Rev Cancer. 2023;23(3):173–88. https://doi.org/10.1038/s41568-022-00531-9.

Article  CAS  PubMed  Google Scholar 

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6(1):92. https://doi.org/10.1038/s41572-020-00224-3. Erratum in: Nat Rev Dis Primers. 2023 Jan 19;9(1):4. PMID: 33243986; PMCID: PMC7944998.

Park SH, Fong KW, Mong E, Martin MC, Schiltz GE, Yu J. Going beyond Polycomb: EZH2 functions in prostate cancer. Oncogene. 2021;40(39):5788–98. https://doi.org/10.1038/s41388-021-01982-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geng Z, Gao Z. Mammalian PRC1 complexes: compositional complexity and diverse molecular mechanisms. Int J Mol Sci. 2020;21(22):8594. https://doi.org/10.3390/ijms21228594.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006;125(2):315–26. https://doi.org/10.1016/j.cell.2006.02.041.

Article  CAS  PubMed  Google Scholar 

Piunti A, Shilatifard A. Epigenetic balance of gene expression by Polycomb and COMPASS families. Science. 2016;352(6290):aad9780. https://doi.org/10.1126/science.aad9780.

Article  CAS  PubMed  Google Scholar 

Sen S, Block KF, Pasini A, Baylin SB, Easwaran H. Genome-wide positioning of bivalent mononucleosomes. BMC Med Genomics. 2016;9(1):60. https://doi.org/10.1186/s12920-016-0221-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brand M, Nakka K, Zhu J, Dilworth FJ. Polycomb/Trithorax antagonism: cellular memory in stem cell fate and function. Cell Stem Cell. 2019;24(4):518–33. https://doi.org/10.1016/j.stem.2019.03.005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaultier C, Foppolo S, Maurange C. Regulation of developmental hierarchy in Drosophila neural stem cell tumors by COMPASS and Polycomb complexes. Sci Adv. 2022;8(19):4529. https://doi.org/10.1126/sciadv.abi4529.

Article  CAS  Google Scholar 

Cheutin T, Cavalli G. Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis. Nat Commun. 2018;9(1):3898. https://doi.org/10.1038/s41467-018-05945-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trojer P, Cao AR, Gao Z, Li Y, Zhang J, Xu X, Li G, Losson R, Erdjument-Bromage H, Tempst P, Farnham PJ, Reinberg D. L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell. 2011;42(4):438–50. https://doi.org/10.1016/j.molcel.2011.04.004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018;25(1):61–72. https://doi.org/10.1038/s41594-017-0007-3.

Article  CAS  PubMed  Google Scholar 

Piunti A, Shilatifard A. The roles of Polycomb repressive complexes in mammalian development and cancer. Nat Rev Mol Cell Biol. 2021;22(5):326–45. https://doi.org/10.1038/s41580-021-00341-1.

Article  CAS  PubMed  Google Scholar 

Zhao X, Wu X. Polycomb-group proteins in the initiation and progression of cancer. J Genet Genom. 2021;48(6):433–43. https://doi.org/10.1016/j.jgg.2021.03.013.

Article  CAS  Google Scholar 

Du Z, Zheng H, Kawamura YK, Zhang K, Gassler J, Powell S, Xu Q, Lin Z, Xu K, Zhou Q, Ozonov EA, Véron N, Huang B, Li L, Yu G, Liu L, Au Yeung WK, Wang P, Chang L, Wang Q, He A, Sun Y, Na J, Sun Q, Sasaki H, Tachibana K, Peters AHFM, Xie W. Polycomb group proteins regulate chromatin architecture in mouse oocytes and early embryos. Mol Cell. 2020;77(4):825-839.e7. https://doi.org/10.1016/j.molcel.2019.11.011.

Article  CAS  PubMed  Google Scholar 

Loubiere V, Papadopoulos GL, Szabo Q, Martinez AM, Cavalli G. Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping. Sci Adv. 2020;6(2):eaax4001. https://doi.org/10.1126/sciadv.aax4001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG. Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. EMBO J. 2011;30(16):3285–97. https://doi.org/10.1038/emboj.2011.243.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell. 2012;45(3):344–56. https://doi.org/10.1016/j.molcel.2012.01.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LLP, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H, Klose RJ. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell. 2014;157(6):1445–59. https://doi.org/10.1016/j.cell.2014.05.004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morey L, Aloia L, Cozzuto L, Benitah SA, Di Croce L. RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells. Cell Rep. 2013;3(1):60–9. https://doi.org/10.1016/j.celrep.2012.11.026.

Article  CAS  PubMed  Google Scholar 

Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J, Bezstarosti K, Taylor S, Ura H, Koide H, Wutz A, Vidal M, Elderkin S, Brockdorff N. RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell. 2012 ;148(4):664–78. https://doi.org/10.1016/j.cell.2011.12.029. Epub 2012 Feb 9. Erratum in: Cell. 2012;149(7):1647–8. PMID: 22325148; PMCID: PMC3281992.

Pherson M, Misulovin Z, Gause M, Mihindukulasuriya K, Swain A, Dorsett D. Polycomb repressive complex 1 modifies transcription of active genes. Sci Adv. 2017;3(8):e1700944. https://doi.org/10.1126/sciadv.1700944.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giner-Laguarda N, Vidal M. Functions of Polycomb proteins on active targets. Epigenomes. 2020;4(3):17. https://doi.org/10.3390/epigenomes4030017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Aldinger KA, Cheng CV, Kiyama T, Dave M, McNamara HK, Zhao W, Stafford JM, Descostes N, Lee P, Caraffi SG, Ivanovski I, Errichiello E, Zweier C, Zuffardi O, Schneider M, Papavasiliou AS, Perry MS, Humberson J, Cho MT, Weber A, Swale A, Badea TC, Mao CA, Garavelli L, Dobyns WB, Reinberg D. NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain. Mol Cell. 2021 Nov 18;81(22):4757. https://doi.org/10.1016/j.molcel.2021.10.023. Erratum for: Mol Cell. 2021 Nov 18;81(22):4663-4676.e8. PMID: 34798045.

Laugesen A, Højfeldt JW, Helin K. Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation. Mol Cell. 2019;74(1):8–18. https://doi.org/10.1016/j.molcel.2019.03.011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004;23(20):4061–71. https://doi.org/10.1038/sj.emboj.7600402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Liefke R, Jiang J, Kurland JV, Tian W, Deng P, Zhang W, He Q, Patel DJ, Bulyk ML, Shi Y, Wang Z. Polycomb-like proteins link the PRC2 complex to CpG islands. Nature. 2017;549(7671):287–91. https://doi.org/10.1038/nature23881.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perino M, van Mierlo G, Karemaker ID, van Genesen S, Vermeulen M, Marks H, van Heeringen SJ, Veenstra GJC. MTF2 recruits polycomb repressive complex 2 by helical-shape-selective DNA binding. Nat Genet. 2018;50(7):1002–10. https://doi.org/10.1038/s41588-018-0134-8.

Article  CAS  PubMed  Google Scholar 

Lee CH, Holder M, Grau D, Saldaña-Meyer R, Yu JR, Ganai RA, Zhang J, Wang M, LeRoy G, Dobenecker MW, Reinberg D, Armache KJ. Distinct stimulatory mechanisms regulate the catalytic activity of polycomb repressive complex 2. Mol Cell. 2018;70(3):435–4485. https://doi.org/10.1016/j.molcel.2018.03.019.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lavarone E, Barbieri CM, Pasini D. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. Nat Commun. 2019;10(1):1679. https://doi.org/10.1038/s41467-019-09624-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun J, Z