Fu, J., Warmflash, A. & Lutolf, M. P. Stem-cell-based embryo models for fundamental research and translation. Nat. Mater. 20, 132–144 (2020).
Article PubMed PubMed Central Google Scholar
Rossant, J. & Tam, P. P. L. Opportunities and challenges with stem cell-based embryo models. Stem Cell Rep. 16, 1031–1038 (2021).
Posfai, E., Lanner, F., Mulas, C. & Leitch, H. G. All models are wrong, but some are useful: establishing standards for stem cell-based embryo models. Stem Cell Rep. 16, 1117–1141 (2021).
Rivron, N. C. et al. Blastocyst-like structures generated solely from stem cells. Nature 557, 106–111 (2018).
Article CAS PubMed Google Scholar
Sozen, B. et al. Self-organization of mouse stem cells into an extended potential blastoid. Dev. Cell 51, 698–712.e8 (2019).
Article CAS PubMed PubMed Central Google Scholar
Li, R. et al. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell 179, 687–702.e18 (2019).
Article CAS PubMed PubMed Central Google Scholar
Harrison, S. E., Sozen, B., Christodoulou, N., Kyprianou, C. & Zernicka-Goetz, M. Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science 356, eaal1810 (2017).
Zhang, S. et al. Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells. Nat. Commun. 10, 496 (2019).
Article PubMed PubMed Central Google Scholar
Sozen, B. et al. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nat. Cell Biol. 20, 979–989 (2018).
Article CAS PubMed Google Scholar
Amadei, G. et al. Inducible stem cell-derived embryos capture mouse morphogenetic events in vitro. Dev. Cell 56, 366–382.e9 (2021).
Article CAS PubMed PubMed Central Google Scholar
Xu, Y. et al. Derivation of totipotent-like stem cells with blastocyst-like structure forming potential. Cell Res 32, 513–529 (2022).
Article CAS PubMed PubMed Central Google Scholar
Shen, H. et al. Mouse totipotent stem cells captured and maintained through spliceosomal repression. Cell 184, 2843–2859.e20 (2021).
Article CAS PubMed Google Scholar
Hu, Y. et al. Induction of mouse totipotent stem cells by a defined chemical cocktail. Nature 617, 792–797 (2022).
Amadei, G. et al. Embryo model completes gastrulation to neurulation and organogenesis. Nature 610, 143–153 (2022).
Article CAS PubMed PubMed Central Google Scholar
Tarazi, S. et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell 185, 3290–3306.e25 (2022).
Article CAS PubMed PubMed Central Google Scholar
Liu, X. et al. Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature 586, 101–107 (2020).
Article CAS PubMed Google Scholar
Tan, J. P., Liu, X. & Polo, J. M. Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts. Nat. Protoc. 17, 2739–2759 (2022).
Article CAS PubMed Google Scholar
Liu, X. et al. Modelling human blastocysts by reprogramming fibroblasts into iBlastoids. Nature 591, 627–632 (2021).
Article CAS PubMed Google Scholar
Yu, L. et al. Blastocyst-like structures generated from human pluripotent stem cells. Nature 591, 620–626 (2021).
Article CAS PubMed Google Scholar
Kagawa, H. et al. Human blastoids model blastocyst development and implantation. Nature 601, 600–605 (2022).
Article CAS PubMed Google Scholar
Yanagida, A. et al. Naive stem cell blastocyst model captures human embryo lineage segregation. Cell Stem Cell 28, 1016–1022.e4 (2021).
Article CAS PubMed PubMed Central Google Scholar
Io, S. et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell 28, 1023–1039.e13 (2021).
Article CAS PubMed Google Scholar
Guo, G. et al. Human naive epiblast cells possess unrestricted lineage potential. Cell Stem Cell 28, 1040–1056.e6 (2021).
Article CAS PubMed PubMed Central Google Scholar
Fan, Y. et al. Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discov. 7, 81 (2021).
Article CAS PubMed PubMed Central Google Scholar
Sozen, B. et al. Reconstructing aspects of human embryogenesis with pluripotent stem cells. Nat. Commun. 12, 5550 (2021).
Article PubMed PubMed Central Google Scholar
Mazid, M. A. et al. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage. Nature 605, 315–324 (2022).
Article CAS PubMed Google Scholar
Yu, X. et al. Recapitulating early human development with 8C-like cells. Cell Rep. 39, 110994 (2022).
Article CAS PubMed Google Scholar
Taubenschmid-Stowers, J. et al. 8C-like cells capture the human zygotic genome activation program in vitro. Cell Stem Cell 29, 449–459.e6 (2022).
Article CAS PubMed PubMed Central Google Scholar
Yu, L. et al. Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk. Cell Stem Cell 30, 1246–1261.e9 (2023).
Article CAS PubMed Google Scholar
Yu, J. et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 324, 797–801 (2009).
Article CAS PubMed PubMed Central Google Scholar
Warren, L. et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618–630 (2010).
Article CAS PubMed PubMed Central Google Scholar
Clark, A. T. et al. Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: considerations leading to the revised ISSCR guidelines. Stem Cell Rep. 16, 1416–1424 (2021).
Lovell-Badge, R. et al. ISSCR guidelines for stem cell research and clinical translation: the 2021 update. Stem Cell Rep. 16, 1398–1408 (2021).
Shahbazi, M. N. et al. Self-organization of the human embryo in the absence of maternal tissues. Nat. Cell Biol. 18, 700–708 (2016).
Article CAS PubMed PubMed Central Google Scholar
Deglincerti, A. et al. Self-organization of the in vitro attached human embryo. Nature 533, 251–254 (2016).
留言 (0)