Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Łosińska K, Korkosz M, Kwaśny-Krochin B. Endothelial dysfunction in patients with ankylosing spondylitis. Reumatologia. 2019;57(2):100–5.

Article  PubMed  PubMed Central  Google Scholar 

Ong P, Sivanathan R, Borgulya G, Bizrah M, Iqbal Y, Andoh J, Gaze D, Kaski JC. Obesity, inflammation and brachial artery flow-mediated dilatation: therapeutic targets in patients with microvascular angina (cardiac syndrome X). Cardiovasc Drugs Ther. 2012;26(3):239–44.

Article  CAS  PubMed  Google Scholar 

Deanfield J, Donald A, Ferri C, Giannattasio C, Halcox J, Halligan S, Lerman A, Mancia G, Oliver JJ, Pessina AC. Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens. 2005;23(1):7–17.

Article  CAS  PubMed  Google Scholar 

Sumagin R, Robin AZ, Nusrat A, Parkos CA. Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment. Mucosal Immunol. 2014;7(4):905–15.

Article  CAS  PubMed  Google Scholar 

Xia YF, Liu LP, Zhong CP, Geng JG. NF-κB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells. Biochem Biophys Res Commun. 2001;289(4):851–6.

Article  CAS  PubMed  Google Scholar 

Dalal PJ, Sumagin R. Emerging functions of ICAM-1 in macrophage efferocytosis and wound healing. J Cell Immunol. 2020;2(5):250–3.

PubMed  PubMed Central  Google Scholar 

Nyborg C, Melsom HS, Bonnevie-Svendsen M, Melau J, Seljeflot I, Hisdal J. Transient reduction of FMD-response and l-arginine accompanied by increased levels of E-selectin, VCAM, and ICAM after prolonged strenuous exercise. Sports (Basel). 2021;9(6):86.

Article  PubMed  Google Scholar 

Arenas-Jal M, Suñé-Negre J, García-Montoya E. Coenzyme Q10 supplementation: efficacy, safety, and formulation challenges. Compr Rev Food Sci Food Saf. 2020;19(2):574–94.

Article  CAS  PubMed  Google Scholar 

Yang YK, Wang LP, Chen L, Yao XP, Yang KQ, Gao LG, Zhou XL. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clin Chim Acta. 2015;450:83–9.

Article  CAS  PubMed  Google Scholar 

Taghizadeh S, Izadi A, Shirazi S, Parizad M, Pourghassem Gargari B. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients. Gynecol Endocrinol. 2021;37(1):26–30.

Article  CAS  PubMed  Google Scholar 

Hamilton SJ, Chew GT, Watts GF. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care. 2009;32(5):810–2.

Article  PubMed  PubMed Central  Google Scholar 

Tiano L, Belardinelli R, Carnevali P, Principi F, Seddaiu G, Littarru GP. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Eur Heart J. 2007;28(18):2249–55.

Article  CAS  PubMed  Google Scholar 

Belardinelli R, Muçaj A, Lacalaprice F, Solenghi M, Seddaiu G, Principi F, Tiano L, Littarru GP. Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J. 2006;27(22):2675–81.

Article  CAS  PubMed  Google Scholar 

Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci. 2008;1147(1):395–412.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gutierrez-Mariscal FM, de la Cruz-Ares S, Torres-Peña JD, Alcalá-Diaz JF, Yubero-Serrano EM, López-Miranda J. Coenzyme Q10 and cardiovascular diseases. Antioxidants. 2021;10(6):906.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao JJ, Xu YX, Jia HP, Zhang L, Cao XY, Zuo XW, Cai GY, Chen XM. Associations of coenzyme Q10 with endothelial function in hemodialysis patients. Nephrology (Carlton). 2021;26(1):54–61.

Article  CAS  PubMed  Google Scholar 

González-Guardia L, Yubero-Serrano EM, Delgado-Lista J, Perez-Martinez P, Garcia-Rios A, Marin C, Camargo A, Delgado-Casado N, Roche HM, Perez-Jimenez F. Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. J Gerontol Ser A. 2015;70(1):78–84.

Article  Google Scholar 

Rabanal-Ruiz Y, Llanos-González E, Alcain FJ. The use of coenzyme Q10 in cardiovascular diseases. Antioxidants. 2021;10(5):755.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sue-Ling CB, Abel WM, Sue-Ling K. Coenzyme Q10 as adjunctive therapy for cardiovascular disease and hypertension: a systematic review. J Nutr. 2022;152(7):1666–74.

Article  PubMed  Google Scholar 

Raitakari OT, McCredie RJ, Witting P, Griffiths KA, Letters J, Sullivan D, Stocker R, Celermajer DS. Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radic Biol Med. 2000;28(7):1100–5.

Article  CAS  PubMed  Google Scholar 

Lim SC, Lekshminarayanan R, Goh SK, Ong YY, Subramaniam T, Sum CF, Ong CN, Lee BL. The effect of coenzyme Q10 on microcirculatory endothelial function of subjects with type 2 diabetes mellitus. Atherosclerosis. 2008;196(2):966–9.

Article  CAS  PubMed  Google Scholar 

Sabbatinelli J, Orlando P, Galeazzi R, Silvestri S, Cirilli I, Marcheggiani F, Dludla PV, Giuliani A, Bonfigli AR, Mazzanti L, et al. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: a randomized clinical trial. Nutrients. 2020;12(4):1098.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohseni M, Vafa M, Zarrati M, Shidfar F, Hajimiresmail SJ, Rahimi Forushani A. Beneficial effects of coenzyme Q10 supplementation on lipid profile and intereukin-6 and intercellular adhesion molecule-1 reduction, preliminary results of a double-blind trial in acute myocardial infarction. Int J Prev Med. 2015;6:73.

Article  PubMed  PubMed Central  Google Scholar 

Gao L, Mao Q, Cao J, Wang Y, Zhou X, Fan L. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis. 2012;221(2):311–6.

Article  CAS  PubMed  Google Scholar 

Salameh J-P, Bossuyt PM, McGrath TA, Thombs BD, Hyde CJ, Macaskill P, Deeks JJ, Leeflang M, Korevaar DA, Whiting P. Preferred reporting items for systematic review and meta-analysis of diagnostic test accuracy studies (PRISMA-DTA): explanation, elaboration, and checklist. BMJ. 2020;370:m2632.

Article  PubMed  Google Scholar 

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JA. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. bmj. 2011;343(7829):1-9.

Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. 2008.

Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5(1):1–10.

Article  Google Scholar 

Iooss B, Lemaître P. A review on global sensitivity analysis methods. In: Uncertainty management in simulation-optimization of complex systems: algorithms and applications 2015; p. 101-22.

Rothwell PM. Subgroup analysis in randomised controlled trials: importance, indications, and interpretation. The Lancet. 2005;365(9454):176–86.

Article  Google Scholar 

Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med. 2002;21(11):1559–73.

Article  PubMed  Google Scholar 

Deeks JJ, Macaskill P, Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol. 2005;58(9):882–93.

Article  PubMed  Google Scholar 

Duval S, Tweedie R. Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56(2):455–63.

Article  CAS  PubMed  Google Scholar 

Borenstein M, Hedges L, Higgins J, Rothstein H. Comprehensive meta-analysis version 2, vol. 104. Englewood: Biostat; 2005.

Google Scholar 

Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini AB, Buettner C, Akuthota P. Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. Crit Care. 2011;15(4):1–8.

Article  Google Scholar 

Donnino MW, Mortensen SJ, Andersen LW, Chase M, Berg KM, Balkema J, Radhakrishnan J, Gazmuri RJ, Liu X, Cocchi MN. Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial. Crit Care. 2015;19:1–11.

Article  Google Scholar 

Hadi NR, Amber KI, Aziz ND. Acute inflammatory response after novolimus drug eluting stent implantation in diabetic patients with coronary artery disease and the impact of coenzyme Q10. World Heart J. 2018;10(1):33–43.

Google Scholar 

Cicero AF, Fogacci F, Di Micoli A, Veronesi M, Borghi C. Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: a double-blind, randomized, placebo-controlled crossover clinical trial. BioFactors. 2022;48(5):1160–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alehagen U, Johansson P, Svensson E, Aaseth J, Alexander J. Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden. Eur J Nutr. 2022;61(6):3135–48.

Article  CAS  PubMed  PubMed Central 

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