Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease

Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A, Saitoh T. The precursor protein of non-A beta component of Alzheimer’s disease amyloid is a presynaptic protein of the central nervous system. Neuron. 1995;14:467–75.

Article  CAS  PubMed  Google Scholar 

Shameli A, Xiao W, Zheng Y, Shyu S, Sumodi J, Meyerson HJ, Harding CV, Maitta RW. A critical role for alpha-synuclein in development and function of T lymphocytes. Immunobiology. 2016;221:333–40.

Article  CAS  PubMed  Google Scholar 

Ettle B, Kuhbandner K, Jorg S, Hoffmann A, Winkler J, Linker RA. Alpha-synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J Neuroinflammation. 2016;13:201.

Article  PubMed  PubMed Central  Google Scholar 

Sommer A, Fadler T, Dorfmeister E, Hoffmann AC, Xiang W, Winner B, Prots I. Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model. J Neuroinflammation. 2016;13:174.

Article  PubMed  PubMed Central  Google Scholar 

Spillantini MG, Goedert M. The alpha-synucleinopathies: Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. Ann N Y Acad Sci. 2000;920:16–27.

Article  CAS  PubMed  Google Scholar 

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology. 2017;89:88–100.

Article  PubMed  PubMed Central  Google Scholar 

Alafuzoff I, Hartikainen P. Alpha-synucleinopathies. Handb Clin Neurol. 2017;145:339–53.

Article  PubMed  Google Scholar 

Savica R, Boeve BF, Mielke MM. When do alpha-synucleinopathies start? An Epidemiological Timeline: a review. JAMA Neurol. 2018;75:503–9.

Article  PubMed  Google Scholar 

Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol. 2022;22:657–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim C, Ho DH, Suk JE, You S, Michael S, Kang J, Joong Lee S, Masliah E, Hwang D, Lee HJ, Lee SJ. Neuron-released oligomeric alpha-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun. 2013;4:1562.

Article  PubMed  Google Scholar 

Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, et al. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating alpha-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018;13:43.

Article  PubMed  PubMed Central  Google Scholar 

Fiebich BL, Batista CRA, Saliba SW, Yousif NM, de Oliveira ACP. Role of Microglia TLRs in Neurodegeneration. Front Cell Neurosci. 2018;12:329.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caplan IF, Maguire-Zeiss KA. Toll-like receptor 2 signaling and current approaches for therapeutic modulation in Synucleinopathies. Front Pharmacol. 2018;9:417.

Article  PubMed  PubMed Central  Google Scholar 

Rostami J, Fotaki G, Sirois J, Mzezewa R, Bergstrom J, Essand M, Healy L, Erlandsson A. Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain. J Neuroinflammation. 2020;17:119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, et al. T cells from patients with Parkinson’s disease recognize alpha-synuclein peptides. Nature. 2017;546:656–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and alpha-synuclein transgenic models. J Neuroinflammation. 2020;17:214.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, et al. CD4(+) T cells contribute to neurodegeneration in Lewy body dementia. Science. 2021;374:868–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Subleski J, Weiss JM, Wiltrout RH, Ortaldo JR. Chapter Nineteen - NK and NKT cells: The innate–adaptive interface including humoral responses. In Natural Killer Cells Edited by Lotze MT, Thomson AW: Academic Press; 2010: 255–277.

Cui Y, Wan Q. NKT cells in neurological diseases. Front Cell Neurosci. 2019;13:245.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y-J, Liao H-F. NK/NKT cells and aging. Int J Gerontol. 2007;1:65–76.

Article  Google Scholar 

Taniguchi M, Seino K, Nakayama T. The NKT cell system: bridging innate and acquired immunity. Nat Immunol. 2003;4:1164–5.

Article  CAS  PubMed  Google Scholar 

Nair S, Dhodapkar MV. Natural killer T cells in Cancer Immunotherapy. Front Immunol. 2017;8:1178.

Article  PubMed  PubMed Central  Google Scholar 

Holbrook J, Patel B, Camacho M, Kahanawita L, Greenland J, Williams-Gray CH. Natural killer cells have an activated profile in early Parkinson’s disease. J Neuroimmunol. 2023;382:578154.

Article  CAS  PubMed  Google Scholar 

Barral DC, Brenner MB. CD1 antigen presentation: how it works. Nat Rev Immunol. 2007;7:929–41.

Article  CAS  PubMed  Google Scholar 

Rossjohn J, Pellicci DG, Patel O, Gapin L, Godfrey DI. Recognition of CD1d-restricted antigens by natural killer T cells. Nat Rev Immunol. 2012;12:845–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watson MB, Richter F, Lee SK, Gabby L, Wu J, Masliah E, Effros RB, Chesselet MF. Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein. Exp Neurol. 2012;237:318–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chesselet MF, Richter F, Zhu C, Magen I, Watson MB, Subramaniam SR. A progressive mouse model of Parkinson’s disease: the Thy1-aSyn (line 61) mice. Neurotherapeutics. 2012;9:297–314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rabl R, Breitschaedel C, Flunkert S, Duller S, Amschl D, Neddens J, Niederkofler V, Rockenstein E, Masliah E, Roemer H, Hutter-Paier B. Early start of progressive motor deficits in line 61 alpha-synuclein transgenic mice. BMC Neurosci. 2017;18:22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, Masliah E. Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res. 2002;68:568–78.

Article  CAS  PubMed  Google Scholar 

Kim C, Beilina A, Smith N, Li Y, Kim M, Kumaran R, Kaganovich A, Mamais A, Adame A, Iba M et al. LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies. Sci Transl Med 2020, 12.

Halder RC, Jahng A, Maricic I, Kumar V. Mini review: immune response to myelin-derived sulfatide and CNS-demyelination. Neurochem Res. 2007;32:257–62.

Article  CAS  PubMed  Google Scholar 

Knieke K, Lingel H, Chamaon K, Brunner-Weinzierl MC. Migration of Th1 lymphocytes is regulated by CD152 (CTLA-4)-mediated signaling via PI3 kinase-dependent akt activation. PLoS ONE. 2012;7:e31391.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer’s disease. Nat Immunol. 2015;16:229–36.

Article  CAS  PubMed  Google Scholar 

Mayne K, White JA, McMurran CE, Rivera FJ, de la Fuente AG. Aging and neurodegenerative disease: is the adaptive Immune System a friend or foe? Front Aging Neurosci. 2020;12:572090.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Molteni M, Rossetti C. Neurodegenerative diseases: the immunological perspective. J Neuroimmunol. 2017;313:109–15.

Article  CAS  PubMed  Google Scholar 

Labzin LI, Heneka MT, Latz E. Innate immunity and neurodegeneration. Annu Rev Med. 2018;69:437–49.

Article  CAS  PubMed  Google Scholar 

Gendelman HE, Mosley RL. A perspective on roles played by Innate and adaptive immunity in the pathobiology of neurodegenerative disorders. J Neuroimmune Pharmacol. 2015;10:645–50.

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