Ginsenoside Rg1 Alleviates Sepsis-Induced Acute Lung Injury by Reducing FBXO3 Stability in an m6A-Dependent Manner to Activate PGC-1α/Nrf2 Signaling Pathway

Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840–51.

Article  CAS  PubMed  Google Scholar 

Hall MJ, Levant S, DeFrances CJ. Trends in inpatient hospital deaths: National Hospital Discharge Survey, 2000–2010. NCHS Data Brief. 2013;118:1–8.

Google Scholar 

Aziz M, Jacob A, Yang WL, Matsuda A, Wang P. Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol. 2013;93(3):329–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu WJ, Wan YD, Tie HT, Kan QC, Sun TW. Risk of acute lung injury/acute respiratory distress syndrome in critically ill adult patients with pre-existing diabetes: a meta-analysis. PLoS ONE. 2014;9(2):e90426.

Article  PubMed  PubMed Central  Google Scholar 

Aziz M, Ode Y, Zhou M, Ochani M, Holodick NE, Rothstein TL, et al. B-1a cells protect mice from sepsis-induced acute lung injury. Mol Med. 2018;24(1):26.

Article  PubMed  PubMed Central  Google Scholar 

Qi LW, Wang CZ, Yuan CS. Isolation and analysis of ginseng: advances and challenges. Nat Prod Rep. 2011;28(3):467–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zou Y, Tao T, Tian Y, Zhu J, Cao L, Deng X, et al. Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes. J Surg Res. 2013;183(2):760–6.

Article  CAS  PubMed  Google Scholar 

Huang L, Cai HA, Zhang MS, Liao RY, Huang X, Hu FD. Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489-3p/Sirt1 axis. J Pharmacol Sci. 2021;147(3):271–83.

Article  CAS  PubMed  Google Scholar 

Luo M, Yan D, Sun Q, Tao J, Xu L, Sun H, et al. Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-kB/NLRP3 pathway. J Cell Biochem. 2020;121(4):2994–3004.

Article  CAS  PubMed  Google Scholar 

Ji Q, Sun Z, Yang Z, Zhang W, Ren Y, Chen W, et al. Protective effect of ginsenoside Rg1 on LPS-induced apoptosis of lung epithelial cells. Mol Immunol. 2021;136:168–74.

Article  CAS  PubMed  Google Scholar 

Wang QL, Yang L, Peng Y, Gao M, Yang MS, Xing W, et al. Ginsenoside Rg1 regulates SIRT1 to ameliorate sepsis-induced lung inflammation and injury via inhibiting endoplasmic reticulum stress and inflammation. Mediators Inflamm. 2019;2019:6453296.

PubMed  PubMed Central  Google Scholar 

Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, et al. Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics. Cell Metab. 2018;27(3):657-66.e5.

Article  CAS  PubMed  Google Scholar 

Andrieux P, Chevillard C, Cunha-Neto E, Nunes JPS. Mitochondria as a Cellular Hub in Infection and Inflammation. Int J Mol Sci. 2021;22(21):11338.

Supinski GS, Schroder EA, Callahan LA. Mitochondria and critical illness. Chest. 2020;157(2):310–22.

Article  CAS  PubMed  Google Scholar 

Kong X, Lin D, Lu L, Lin L, Zhang H, Zhang H. Apelin-13-Mediated AMPK ameliorates endothelial barrier dysfunction in acute lung injury mice via improvement of mitochondrial function and autophagy. Int Immunopharmacol. 2021;101(Pt B):108230.

Article  CAS  PubMed  Google Scholar 

Johri A, Chandra A, Flint BM. PGC-1α, mitochondrial dysfunction, and Huntington’s disease. Free Radic Biol Med. 2013;62:37–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Gao W, Zhao Z, Li Y, Yang L, Wei W, et al. Ginsenoside Rg1 reduced microglial activation and mitochondrial dysfunction to alleviate depression-like behaviour via the GAS5/EZH2/SOCS3/NRF2 axis. Mol Neurobiol. 2022;59(5):2855–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Pan H, Zhang Y, Zheng Z, Xiao W, Hong X, et al. Ginsenoside-Rg1 attenuates sepsis-induced cardiac dysfunction by modulating mitochondrial damage via the P2X7 receptor-mediated Akt/GSK-3β signaling pathway. J Biochem Mol Toxicol. 2022;36(1):e22885.

Article  CAS  PubMed  Google Scholar 

Qin Q, Lin N, Huang H, Zhang X, Cao X, Wang Y, et al. Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats. Diabetes Metab Syndr Obes. 2019;12:1091–103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Xiao X, Luo J, Wang J, Peng Q, Zhao J, et al. E3 ubiquitin ligase FBXO3 drives neuroinflammation to aggravate cerebral ischemia/reperfusion injury. Int J Mol Sci. 2022;23(21):13648.

Mallampalli RK, Coon TA, Glasser JR, Wang C, Dunn SR, Weathington NM, et al. Targeting F box protein Fbxo3 to control cytokine-driven inflammation. J Immunol. 2013;191(10):5247–55.

Article  CAS  PubMed  Google Scholar 

Chen BB, Coon TA, Glasser JR, McVerry BJ, Zhao J, Zhao Y, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol. 2013;14(5):470–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hung KY, Liao WI, Pao HP, Wu SY, Huang KL, Chu SJ. Targeting F-box protein Fbxo3 attenuates lung injury induced by ischemia-reperfusion in rats. Front Pharmacol. 2019;10:583.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qian M, Lou Y, Wang Y, Zhang M, Jiang Q, Mo Y, et al. PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT. Free Radic Biol Med. 2018;118:23–34.

Article  CAS  PubMed  Google Scholar 

Zheng F, Wu X, Zhang J, Fu Z, Zhang Y. Sevoflurane reduces lipopolysaccharide-induced apoptosis and pulmonary fibrosis in the RAW264.7 cells and mice models to ameliorate acute lung injury by eliminating oxidative damages. Redox: Rep Commun Free Radic Res. 2022;27(1):139–49.

Article  CAS  Google Scholar 

Liang D, Huang A, Jin Y, Lin M, Xia X, Chen X, et al. Protective effects of exogenous NaHS against sepsis-induced myocardial mitochondrial injury by enhancing the PGC-1α/NRF2 pathway and mitochondrial biosynthesis in mice. Am J Transl Res. 2018;10(5):1422–30.

CAS  PubMed  PubMed Central  Google Scholar 

Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, et al. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic Acids Res. 2020;48(7):3816–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang M, Cai S, Su J. The pathogenesis of sepsis and potential therapeutic targets. Int J Mol Sci. 2019;20(21):5376.

Hudson LD, Milberg JA, Anardi D, Maunder RJ. Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med. 1995;151(2 Pt 1):293–301.

Article  CAS  PubMed  Google Scholar 

Iscimen R, Cartin-Ceba R, Yilmaz M, Khan H, Hubmayr RD, Afessa B, et al. Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study. Crit Care Med. 2008;36(5):1518–22.

Article  PubMed  Google Scholar 

Mu G, Deng Y, Lu Z, Li X, Chen Y. miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2. Acta Biochim Biophys Sin (Shanghai). 2021;53(2):220–8.

Article  CAS  PubMed  Google Scholar 

Yu T, Tang Y, Zhang F, Zhang L. Roles of ginsenosides in sepsis. J Ginseng Res. 2023;47(1):1–8.

Article  PubMed  Google Scholar 

Guo J, Wang R, Min F. Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells. J Leukoc Biol. 2022;112(5):1065–77.

Article  CAS  PubMed  Google Scholar 

Xu M, Ma Q, Fan C, Chen X, Zhang H, Tang M. Ginsenosides Rb1 and Rg1 protect primary cultured astrocytes against oxygen-glucose deprivation/reoxygenation-induced injury via improving mitochondrial function. Int J Mol Sci. 2019;20(23):6086.

Qu M, Chen Z, Qiu Z, Nan K, Wang Y, Shi Y, et al. Neutrophil extracellular traps-triggered impaired autophagic flux via METTL3 underlies sepsis-associated acute lung injury. Cell Death Discov. 2022;8(1):375.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu C, Yang L, Wang Y, Zhou S, Luo J, Gu Y. Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop. J Ginseng Res. 2021;45(6):734–43.

Article  PubMed  PubMed Central  Google Scholar 

Han Z, Wang X, Xu Z, Cao Y, Gong R, Yu Y, et al. ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1. Theranostics. 2021;11(6):3000–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Guan X, Liu W, Zhu Z, Jin H, Zhu Y, et al. YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis. Cell Death Discov. 2022;8(1):244.

Article  PubMed  PubMed Central  Google Scholar 

Fontecha-Barriuso M, Martin-Sanchez D, Martinez-Moreno JM, Monsalve M, Ramos AM, Sanchez-Niño MD, et al. The role of PGC-1α and mitochondrial biogenesis in kidney diseases. Biomolecules. 2020;10(2):347.

Gleyzer N, Vercauteren K, Scarpulla RC. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nucle

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